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Bovine (Bos taurus) TRA/TRD locus on chromosome 10

TRDV genes are designated by a number for the subgroup followed, whenever there are several genes belonging to the same subgroup, by the letter S and a number for their relative localization in that representation.
TRDV gene names with a hyphen followed by a number correspond to genes with identical V-REGION sequences.

TRAJ genes are designated by a number according to their localization from 3' to 5' in the locus.

TRAV genes have not been found, so they are not represented in that locus representation.

Locus representation bovine TRA/TRD

Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.

The relative position of the clones containing the Bos taurus TRDV genes and their orientation in the locus are still unknown.
Therefore, for these clones, 5' and 3' refer to the 5'->3' DNA strand orientation.

In contrast, for clone Btau3.1_Chr10.30 (that contains the TRDD, TRDJ, TRDC, TRDV4, TRAJ and TRAC genes)
5' and 3' refer to the orientation in the Bos taurus TRA/TRD locus, by homology with the Homo sapiens and Mus musculus TRA/TRD loci.

Arrows indicate transcriptional orientation of the TRDV genes:
- for TRDV4, in the Bos taurus TRA/TRD locus
- for the other TRDV genes, in their clone sequences.

More information:
IMGT references:
  1. [1] Herzig, C.T. et al., BMC Genomics, 11, 100-100 (2010). PMID: 20144200
  2. [2] Herzig, C.T. et al., Immunogenetics, 58, 746-757 (2006). PMID: 16896832
  3. [3] Reinink, P. et al., Immunogenetics, 61, 541-549 (2009). PMID: 19568741
  4. [4] Van Rhijn, I. et al., Mol Immunol., 44, 3155-3161 (2007). PMID: 17418895
  5. [5] Blumerman, S.L. et al., Immunogenetics, 58, 680-692 (2006). PMID: 16799810
  6. [6] Hein, W.R. et al., Immunology, 91, 58-64 (1997). PMID: 9203966