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Bovine (Bos taurus) TRG locus on chromosome 4 (4q3.1 and 4q1.5-2.2)

In cattle (bovine, Bos taurus) and sheep (ovine, Ovis aries), the TRG genes are organized in two separate loci on chromosome 4:

  • The TRG1 locus at position 4q3.1 spans about 250 kb and comprises four TRGC genes (TRGC3, TRGC4, TRGC5 and TRGC7).
  • The TRG2 locus at 4q1.5-2-2 spans about 190 kb and comprises three TRGC (TRGC1, TRGC2 and TRGC6).

Locus representation bovine TRG

Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.

Arrows indicate the TRGC cassettes and the transcriptional orientation of their genes.

* In AY644518 TRGV5-2 is rearranged with TRGJ2-1 and TRGV6-2 is rearranged with TRGJ6-1.

Locus representation with only the functional genes: Bovine (Bos taurus) TRG

Locus representation bovine TRG

* When needed, indicate the presence of allele(s) with another functionality: see above Bovine (Bos taurus) TRG locus

IMGT references:
  1. [1] Ishiguro, N. et al., Immunogenetics, 38, 437-443 (1993). PMID: 8406615
  2. [2] Hein, W. R. et al., Immunology, 91, 58-64 (1997). PMID: 9203966
  3. [3] Lahmers, K.K. et al., J. Leukoc. Biol., 77, 199-208 (2005). PMID: 15522917
  4. [4] Herzig, C. et al., Immunogenetics, 58, 138-151 (2006). PMID: 16541255
  5. [5] Conrad, M. et al., Vet. Immunol. Immunopathol.,115, 346-356 (2007). PMID: 17141331