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Citing this page:
Lefranc, M.-P., Exp. Clin. Immunogenet., 18, 242-254 (2001). PMID: 11872955 pdf
Lefranc, M.-P. and Lefranc, G., The Immunoglobulin FactsBook, Academic Press, London, 458 pages (2001). pdf
Lefranc, M.-P. and Lefranc, G., In: Molecular Biology of B cells, pp 37-59 (2004).

Human (Homo sapiens) IGL locus on chromosome 22 (22q11.2)

The orientation of the human (Homo sapiens) IGL locus on the chromosome 22 (22q11.2) is forward (FWD).

Locus representation human IGL

Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.

A, B, C refer to three distinct V-CLUSTERs based on the IGLV gene subgroup content [6].

IGLV gene names are designated by a number for the subgroup [4,6] followed by a dash and a number for the localization from 3' to 5' in the locus.
Pseudogenes which could not be assigned to subgroups with functional genes are designated by a roman number between parentheses, corresponding to the clans [7], followed by a dash and a number for the localization from 3' to 5' in the locus.
Clans (Figure IGLV clans) comprise, respectively:

  • clan I: IGLV1, IGLV2, IGLV6 and IGLV10 subgroup genes, and pseudogenes IGLV(I)-20, -38, -42, -56, -63, -68 and -70
  • clan II: IGLV3 subgroup genes
  • clan III: IGLV7 and IGLV8 subgroup genes
  • clan IV: IGLV5 and IGLV11 subgroup genes, and pseudogenes IGLV(IV)-53, -59, -64, -65 and -66-1
  • clan V: IGLV4 and IGLV9 subgroup genes, and pseudogenes IGLV(V)-58 and -66
  • clan VI: pseudogenes IGLV(VI)-22-1 and -25-1
  • clan VII: pseudogene IGLV(VII)-41-1

IGLV(IV)-66-1 has been identified in D87004 by IMGT curators (G. Folch, V. Giudicelli, M.-P. Lefranc).
IGLV(VI)-25-1 has been identified in D86994 by IMGT curators (N. Bosc, M.-P. Lefranc).

Locus representation with only the functional genes: Human (Homo sapiens) IGL

Gene localization is according to data from IMGT/LocusView. This locus representation with only the functional genes is used with IMGT/GeneFrequency.

Locus representation human IGL

* When needed, indicate the presence of allele(s) with another functionality: see above Human (Homo sapiens) IGL locus

Zoom for IGLJ genes

zoom

IMGT references:
  1. [1] Lefranc, M.-P. and Lefranc, G., The immunoglobulin FactsBook, Academic Press, London, 458 pages (2001). 012441351X
  2. [2] Lefranc, M.-P., Nomenclature of the human immunoglobulin genes, Current Protocols in Immunology, A.1P.1-A.1P.37 (2000).
  3. [3] Lefranc, M.-P. and Lefranc, G., Immunoglobulin lambda (IGL) genes of human and mouse, In: Molecular Biology of B cells (Honjo, T., Alt, F.W. and Neuberger, M.S. eds), Academic Press, Elsevier Science, pp. 37-59 (2004). 0120536412
IGLV genes
  1. [4] Frippiat, J.-P. et al., Hum. Mol. Genet., 4, 983-991 (1995).
  2. [5] Kawasaki, K. et al., Genome Res., 5, 125-135 (1995).
  3. [6] Williams, S.C., Frippiat, J.-P. et al., J. Mol. Biol., 264, 220-232 (1996).
  4. [7] Kawasaki, K. et al., Genome Res., 7, 250-261 (1997).
IGLJ genes and IGLC genes
  1. [8] Hieter, P.A. et al., Nature, 294, 536-540 (1981).
  2. [9] Taub, R.A. et al., Nature, 304, 172-174 (1983).
  3. [10] Dariavach, P. et al., Proc. Natl. Acad. Sci., 84, 9074-9078 (1987).
  4. [11] Vasicek, T.J. and Leder, P., J. Exp. Med., 1990, 609-620 (1990).
IGLC polymorphisms
  1. [12] Taub, R.A. et al., Nature, 304, 172-174 (1983).
  2. [13] Ghanem, N. et al., Exp. Clin. Immunogenet., 5, 186-195 (1988).
  3. [14] Kay, P.H. et al., Immunogenetics, 35, 341-343 (1992).
  4. [15] Lefranc, M.-P. et al., Hum. Genet., 104, 361-369 (1999).
IGLV polymorphisms
  1. [16] Lefranc, M.-P. et al., Hum. Genet., 104, 361-369 (1999).
Enhancer
  1. [17] Blomberg, B.B. et al., J. Immunol., 147, 2354-2358 (1991).
  2. [18] Asenbauer, H. et al., Eur. J. Immunol., 29, 713-724 (1999).
  3. [19] Combriato, G. and Klobeck, H.G., J. Immunol., 168, 1259-1266 (2002).