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Citing this page: Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, London, 398 pages (2001)

Human (Homo sapiens) TRA/TRD locus on chromosome 14 (14q11.2)

The orientation of the human (Homo sapiens) TRA/TRD locus on the chromosome 14 (14q11.2) is forward (FWD).

Locus representation human TRA/TRD

Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.
A double slash // indicates a gap in genome assembly. Distances in bp (base pair) or in kb (kilobase) associated with a double slash are taken into account in the length of the lines and included in the numbers displayed at the right end of the lines.
A dotted line ... indicates the distance in kb (kilobase) between the locus and its bornes (5' borne and the most 5' gene in the locus and/or 3' borne and the most 3' gene in the locus) on the top and bottom lines, respectively. These distances are not represented at scale and are not included in the numbers displayed at the right ends of these two lines.

A small arrow shows a gene (TRDV3) whose polarity is opposite to that of the TRD D-J-C-CLUSTER.

Bornes of the human (Homo sapiens) TRA/TRD locus

• No 5' borne conserved between species has been identified upstream of TRAV1-1 (F), the most 5' gene in the locus.
• DAD1 (defender agaisnt cell death) (3' borne) has been identified 13 kb downstream of TRAC (F), the most 3' gene in the locus.

Locus representation with only the functional genes: Human (Homo sapiens) TRA/TRD

Gene localization is according to data from IMGT/LocusView.
This locus representation with only the functional genes is used with IMGT/GeneFrequency.

Locus representation human TRA/TRD

* When needed, indicate the presence of allele(s) with another functionality: see above Human (Homo sapiens) TRA/TRD locus

Zoom for TRA/TRDJ genes

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IMGT references:
  1. [1] Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, London, 398 pages (2001).
  2. [2] Lefranc, M.-P., Nomenclature of the human T cell receptor genes, Current Protocols in Immunology, A.1O.1-A.1O.23 (2000).
TRAV genes
  1. [3] Boysen, C. et al., unpublished (AE000658,AE000659,AE000660,AE000661).
TRAV alignments
  1. [4] Arden, B. et al., Immunogenetics, 42, 455-500 (1995).
TRAJ genes
  1. [5] Koop, B.F. et al., Genomics, 19, 478-493 (1994).
TRAC genes
  1. [6] Baer, R. et al., Mol. Biol. Med., 3, 265-277 (1986).
  2. [7] Yoshikai, Y. et al., Nature, 316, 837-840 (1985).
TRA enhancer (4,5 kb 3' from TRAC)
  1. [8] Ho, I.C. et al., Proc. Natl. Acad. Sci. USA, 86, 6714-6718 (1989).
TRDV genes
  1. [9] Boysen, C. et al., unpublished (AE000660,AE000661).
TRDD genes
  1. [10] Takihara, Y. et al., Proc. Natl. Acad. Sci. USA. 85, 6097-6101 (1988).
  2. [11] Loh, E.Y. et al., Proc. Natl. Acad. Sci. USA. 85, 9714-9718 (1988).
TRDJ genes
  1. [12] Isobe, M. et al., Proc. Natl. Acad. Sci. USA. 85, 3933-3937 (1988).
  2. [13] Loh, E.Y. et al., Proc. Natl. Acad. Sci. USA. 85, 9714-9718 (1988).
  3. [14] Satyanarayana, K. et al., Proc. Natl. Acad. Sci. USA. 85, 8166-8170 (1988).
TRDC genes
  1. [15] Takihara, Y. et al., Proc. Natl. Acad. Sci. USA. 85, 6097-6101 (1988).
TRD enhancer (between TRDJ3 and TRDC)
  1. [16] Redondo, J.M. et al., Science, 247, 1225-1229 (1990).
  2. [17] Bories, J.C. et al., J. Exp. Med. 171, 75-83 (1990).
Created:
11/07/2003
Last updated:
14/03/2019
Authors:
Dominique Scaviner and Marie-Paule Lefranc
Editors:
Chantal Ginestoux