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Citing this page: Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, London, 398 pages (2001)

Human (Homo sapiens) TRA/TRD locus on chromosome 14 (14q11.2)

The orientation of the human (Homo sapiens) TRA/TRD locus on the chromosome 14 (14q11.2) is forward (FWD).

Locus representation human TRA/TRD

Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.

A small arrow shows a gene (TRDV3) whose polarity is opposite to that of the TRD D-J-C-CLUSTER.

Locus representation with only the functional genes: Human (Homo sapiens) TRA/TRD

Gene localization is according to data from IMGT/LocusView.
This locus representation with only the functional genes is used with IMGT/GeneFrequency.

Locus representation human TRA/TRD

* When needed, indicate the presence of allele(s) with another functionality: see above Human (Homo sapiens) TRA/TRD locus

Zoom for TRA/TRDJ genes

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More information:
IMGT references:
  1. [1] Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, London, 398 pages (2001).
  2. [2] Lefranc, M.-P., Nomenclature of the human T cell receptor genes, Current Protocols in Immunology, A.1O.1-A.1O.23 (2000).
TRAV genes
  1. [3] Boysen, C. et al., unpublished (AE000658,AE000659,AE000660,AE000661).
TRAV alignments
  1. [4] Arden, B. et al., Immunogenetics, 42, 455-500 (1995).
TRAJ genes
  1. [5] Koop, B.F. et al., Genomics, 19, 478-493 (1994).
TRAC genes
  1. [6] Baer, R. et al., Mol. Biol. Med., 3, 265-277 (1986).
  2. [7] Yoshikai, Y. et al., Nature, 316, 837-840 (1985).
TRA enhancer (4,5 kb 3' from TRAC)
  1. [8] Ho, I.C. et al., Proc. Natl. Acad. Sci. USA, 86, 6714-6718 (1989).
TRDV genes
  1. [9] Boysen, C. et al., unpublished (AE000660,AE000661).
TRDD genes
  1. [10] Takihara, Y. et al., Proc. Natl. Acad. Sci. USA. 85, 6097-6101 (1988).
  2. [11] Loh, E.Y. et al., Proc. Natl. Acad. Sci. USA. 85, 9714-9718 (1988).
TRDJ genes
  1. [12] Isobe, M. et al., Proc. Natl. Acad. Sci. USA. 85, 3933-3937 (1988).
  2. [13] Loh, E.Y. et al., Proc. Natl. Acad. Sci. USA. 85, 9714-9718 (1988).
  3. [14] Satyanarayana, K. et al., Proc. Natl. Acad. Sci. USA. 85, 8166-8170 (1988).
TRDC genes
  1. [15] Takihara, Y. et al., Proc. Natl. Acad. Sci. USA. 85, 6097-6101 (1988).
TRD enhancer (between TRDJ3 and TRDC)
  1. [16] Redondo, J.M. et al., Science, 247, 1225-1229 (1990).
  2. [17] Bories, J.C. et al., J. Exp. Med. 171, 75-83 (1990).