The orientation of the human (Homo sapiens) TRB locus on the chromosome 7 (7q34) is forward (FWD).
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.
TRBV gene designations according to Rowen et al. (1996). Nomenclature adopted by IMGT.
Single arrows show genes whose polarity is opposite to that of the D-J-C-CLUSTER. Double arrows indicate insertion/deletion polymorphisms.
• PRSS58 (serine protease 58, trypsinogen-like TRYX3, TRY1) (5' borne) has been identified 41 kb upstream of TRBV1 (P), the most 5' gene in the locus.
• EPHB6 (EPH receptor B6) (3' borne) has been identified 41 kb downstream of TRBV30 (F), the most 3' gene in the locus.
T3 to T8 indicate trypsinogen or trypsinogen-like genes. T3 (PRSS3P3, TRY3) is at 7.4 kb upstream of TRBV1. T4 to T8 are localized between TRBV29-1 and TRBD1.
Gene localization is according to data from
This locus representation with only the functional genes is used with IMGT/GeneFrequency.
* When needed, indicate the presence of allele(s) with another functionality: see above Human (Homo sapiens) TRB locus