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Citing this page: Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, London, 398 pages (2001)

Human (Homo sapiens) TRB locus on chromosome 7 (7q34)

The orientation of the human TRB locus on the chromosome is forward (FWD).

Locus representation human TRB

Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.

TRBV gene designations according to Rowen et al. (1996). Nomenclature adopted by IMGT.
Single arrows show genes whose polarity is opposite to that of the D-J-C-CLUSTER. Double arrows indicate insertion/deletion polymorphisms.

Locus representation with only the functional genes: Human (Homo sapiens) TRB

Gene localization is according to data from IMGT/LocusView.
This locus representation with only the functional genes is used with IMGT/GeneFrequency.

Locus representation human TRB

* When needed, indicate the presence of allele(s) with another functionality: see above Human (Homo sapiens) TRB locus

Zoom for TRBD and TRBJ genes

zoom

More information:
IMGT references:
  1. [1] Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, London, 398 pages (2001).
  2. [2] Lefranc, M.-P., Nomenclature of the human T cell receptor genes, Current Protocols in Immunology, A.1O.1-A.1O.23 (2000).
TRBV genes
  1. [3] Wei, S. et al., Immunogenetics, 40, 27-36 (1994).
  2. [4] Posnett, D.N. et al., The Immunologist, 4, 5-8 (1996).
  3. [5] Rowen, L. et al., Science, 272, 1755-1762 (1996).
TRB D-J-C-CLUSTER
  1. [6] Toyonaga, B. et al., Proc. Natl. Acad. Sci. USA, 82, 8624-8628 (1985).
  2. [7] Tunnacliffe, A. et al., Proc. Natl. Acad. Sci. USA, 82, 5068-5072 (1985).
TRBV alignments
  1. [8] Arden, B. et al., Immunogenetics, 42, 455-500 (1995).
TRBV enhancer (5.5 kb 3' from TRBC2)
  1. [9] Gottschalk, L.R. and Leiden, J.M., Mol. Cell. Biol., 10, 5486-5495 (1990).