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Citing this page:
Lefranc, M.-P. et al., Eur. J. Immunol., 19, 989-994 (1989) PMID: 2526744
Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, London, 398 pages (2001)

Human (Homo sapiens) TRG locus on chromosome 7 (7p14)

The orientation of the human (Homo sapiens) TRG locus on the chromosome 7 (7p14) is reverse (REV).

Locus representation human TRG

Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.

TRBV gene designations according to Rowen et al. (1996). Nomenclature adopted by IMGT.
Single arrows show genes whose polarity is opposite to that of the D-J-C-CLUSTER. Double arrows indicate insertion/deletion polymorphisms.

Locus representation with only the functional genes: Human (Homo sapiens) TRG

Gene localization is according to data from IMGT/LocusView.
This locus representation with only the functional genes is used with IMGT/GeneFrequency.

Locus representation human TRG

* When needed, indicate the presence of allele(s) with another functionality: see above Human (Homo sapiens) TRG locus

Zoom for TRGJ genes

zoom

IMGT references:
  1. [1] Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, London, 398 pages (2001).
  2. [2] Lefranc, M.-P., Nomenclature of the human T cell receptor genes, Current Protocols in Immunology, A.1O.1-A.1O.23 (2000).
  3. [3] Lefranc, M.-P. and Rabbitts, T.H., TIBS, 14, 214-218 (1989). PMID: 2527426
  4. [4] Lefranc, M.-P. et al., Eur. J. Immunol., 19, 989-994 (1989). PMID: 2526744
  5. [5] Lefranc, M.-P. and Rabbitts, T.H., Res. Immunol., 141, 565-577 (1990). PMID: 2151348
  6. [6] Lefranc, M.-P. and Rabbitts, T.H., Res. Immunol., 141, 615-618 (1990). PMID: 1965674
TRGV genes
  1. [7] Lefranc, M.-P. et al., Cell, 45, 237-246 (1986). PMID: 2938743
  2. [8] Forster, A. et al., EMBO J., 6, 1945-1950 (1987). PMID: 2820713
  3. [9] Huck, S. et al., EMBO J., 7, 719-726 (1988). PMID: 2969332
  4. [10] Zhang, X.M. et al., Eur. J. Immunol., 24, 571-578 (1994). PMID: 8125127
  5. [11] Zhang, X.M. et al., Immunogenetics, 43, 196-203 (1996). PMID: 8575818
TRGJ genes
  1. [12] Huck, S. and Lefranc, M.-P., FEBS Lett., 224, 291-296 (1987). PMID: 2961609
TRGC genes
  1. [13] Lefranc, M.-P. et al., Proc. Natl. Acad. Sci., 83, 9596-9600 (1986). PMID: 2879283
  2. [14] Buresi, C. et al., Immunogenetics, 29, 161-172 (1989). PMID: 2564370
Silencers and enhancer
  1. [15] Lefranc, M.-P. and Alexandre, D., Eur. J. Immunol., 25, 617-622 (1995). PMID: 7875223
RFLP polymorphisms of the TRGV and TRGC genes
  1. [16] Buresi, C. et al., Immunogenetics, 29, 161-172 (1989). PMID: 2564370
  2. [17] Ghanem, N. et al., Immunogenetics, 30, 350-360 (1989). PMID: 2572547
  3. [18] Ghanem, N. et al., Human Genet., 86, 450-456 (1991). PMID: 1673112