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Citing this page:
Lefranc, M.-P. et al., Eur. J. Immunol., 19, 989-994 (1989) PMID: 2526744
Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, London, 398 pages (2001) IMGT/LIGM-DB: IMGT000011 (582960 bp), human (Homo sapiens) TRG locus.

Human (Homo sapiens) TRG locus on chromosome 7 (7p14)

The orientation of the human (Homo sapiens) TRG locus on the chromosome 7 (7p14) is reverse (REV).

Locus representation human TRG

Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.
A double slash // indicates a gap in genome assembly. Distances in bp (base pair) or in kb (kilobase) associated with a double slash are taken into account in the length of the lines and included in the numbers displayed at the right end of the lines.
A dotted line ... indicates the distance in kb (kilobase) between the locus and its bornes (5' borne and the most 5' gene in the locus and/or 3' borne and the most 3' gene in the locus) on the top and bottom lines, respectively. These distances are not represented at scale and are not included in the numbers displayed at the right ends of these two lines.

A double arrow indicates insertion/deletion polymorphisms.

Bornes of the human (Homo sapiens) TRG locus

• AMPH (amphiphysin) (5' borne) has been identified 16 kb upstream of TRGV1 (ORF), the most 5' gene in the locus.
• STARD3NL (STARD3 N-terminal like) (3' borne) has been identified 9,4 kb downstream of TRGC2 (F), the most 3' gene in the locus.

Locus representation with only the functional genes: Human (Homo sapiens) TRG

Gene localization is according to data from IMGT/LocusView.
This locus representation with only the functional genes is used with IMGT/GeneFrequency.

Locus representation human TRG

* When needed, indicate the presence of allele(s) with another functionality: see above Human (Homo sapiens) TRG locus

Zoom for TRGJ genes

zoom

IMGT references:
  1. [1] Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, London, 398 pages (2001).
  2. [2] Lefranc, M.-P., Nomenclature of the human T cell receptor genes, Current Protocols in Immunology, A.1O.1-A.1O.23 (2000).
  3. [3] Lefranc, M.-P. and Rabbitts, T.H., TIBS, 14, 214-218 (1989). PMID: 2527426
  4. [4] Lefranc, M.-P. et al., Eur. J. Immunol., 19, 989-994 (1989). PMID: 2526744
  5. [5] Lefranc, M.-P. and Rabbitts, T.H., Res. Immunol., 141, 565-577 (1990). PMID: 2151348
  6. [6] Lefranc, M.-P. and Rabbitts, T.H., Res. Immunol., 141, 615-618 (1990). PMID: 1965674
TRGV genes
  1. [7] Lefranc, M.-P. et al., Cell, 45, 237-246 (1986). PMID: 2938743
  2. [8] Forster, A. et al., EMBO J., 6, 1945-1950 (1987). PMID: 2820713
  3. [9] Huck, S. et al., EMBO J., 7, 719-726 (1988). PMID: 2969332
  4. [10] Zhang, X.M. et al., Eur. J. Immunol., 24, 571-578 (1994). PMID: 8125127
  5. [11] Zhang, X.M. et al., Immunogenetics, 43, 196-203 (1996). PMID: 8575818
TRGJ genes
  1. [12] Huck, S. and Lefranc, M.-P., FEBS Lett., 224, 291-296 (1987). PMID: 2961609
TRGC genes
  1. [13] Lefranc, M.-P. et al., Proc. Natl. Acad. Sci., 83, 9596-9600 (1986). PMID: 2879283
  2. [14] Buresi, C. et al., Immunogenetics, 29, 161-172 (1989). PMID: 2564370
Silencers and enhancer
  1. [15] Lefranc, M.-P. and Alexandre, D., Eur. J. Immunol., 25, 617-622 (1995). PMID: 7875223
RFLP polymorphisms of the TRGV and TRGC genes
  1. [16] Buresi, C. et al., Immunogenetics, 29, 161-172 (1989). PMID: 2564370
  2. [17] Ghanem, N. et al., Immunogenetics, 30, 350-360 (1989). PMID: 2572547
  3. [18] Ghanem, N. et al., Human Genet., 86, 450-456 (1991). PMID: 1673112
Created:
21/07/1995
Last updated:
29/11/2018
Authors:
Marie-Paule Lefranc
Editor:
Chantal Ginestoux