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Citing this page: Martinez-Jean, C. et al., Exp. Clin. Immunogenet., 18, 255-279 (2001) PMID: 11872956 pdf

House mouse (Mus musculus) IGK locus on chromosome 6 (6C1)

The orientation of the mouse (Mus musculus) IGK locus on the chromosome 6 (6C1) is forward (FWD).

Locus representation mouse IGK

Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.

|   Sequences used as probes.

IGKV4-52 is not found in BAC clone AC153615. It is not yet known if IGKV4-52 represents an allele of the IGKV4-54 or a polymorphic gene by insertion deletion.

The D6Bhm9 probe (EMBL Accession number Z72363) is described in Schupp, I.W. et al., Immunogenetics, 95, 180-187 (1997).

tub: a- tubulin like (EMBL Accession number AJ235970).
sad: S-adenosyl methionine decarboxylase like (EMBL Accession number AJ132684).

The 5' enhancer (E5') is found between the IGKJ genes and the IGKC genes, and the 3' enhancer (E3') is located 8.5 kb downstream of the IGKC gene.

The 19 mouse (Mus musculus) IGKV subgroups belong to three clans (Figure IGKV clans). Clans comprise, respectively:

  • clan I: IGKV9, IGKV10, IGKV11, IGKV12, IGKV13, IGKV14, IGKV15, IGKV16 and IGKV19 subgroup genes
  • clan II: IGKV1, IGKV2, IGKV5, IGKV6, IGKV7, IGKV8 and IGKV18 subgroup genes
  • clan III: IGKV3, IGKV4 and IGKV17 subgroup genes

Locus representation with only the functional genes: House mouse (Mus musculus) IGK

Locus representation mouse IGK

* When needed, indicate the presence of allele(s) with another functionality: see above House mouse (Mus musculus) IGK locus

IMGT notes:
  1. (1) The mouse IGKV representation has been set up with data from [1-5] and updated with "The immunoglobulin k genes and the k locus of the mouse".These updates (26/05/2005) include:
    • deletion of the gaps between IGKV14-111 and IGKV2-112, and between IGKV2-116 and IGKV1-117
    • deletion of the gaps between IGKV1-122 and IGKV9-123, and between IGKV9-124 and IGKV11-125, and change of orientation and position of the IGKV9-123 and IGKV9-124 genes
    • deletion of gw1, ca9 and cc9, now considered as orphons on the same chromosome 6 (IGKV1/OR6-1, IGKV14/OR6-2 and IGKV14/OR6-3, respectively).
    These updates (17/07/2006) include:
    • Addition of IGKV8-23-1, IGKV4-57-1 and IGKV13-57-2.
    • Positioning of IGKV4-60 between IGKV4-59 and IGKV4-58.
IMGT references:
IGKV genes
  1. [1] Kirschbaum, T. et al., Eur. J. Immunol., 28, 1458-1466 (1998).
  2. [2] Kirschbaum, T. et al., Eur. J. Immunol., 29, 2057-2064 (1999).
  3. [3] Röschenthaler, F. et al., Eur. J. Immunol., 29, 2065-2071 (1999).
  4. [4] Thiebe, R. et al., Eur. J. Immunol., 29, 2072-2081 (1999).
  5. [5] Schäble, K.F. et al., Eur. J. Immunol., 29, 2082-2086 (1999).
IGKJ genes and IGKC gene
  1. [6] Sakano, H. et al., Nature, 280, 288-294 (1979).
  2. [7] Max, E.E. et al., Proc. Natl. Acad. Sci., USA, 76, 3450-3454 (1979).
  3. [8] Max, E.E. et al., J. Biol. Chem., 256, 5116-5120 (1981).
E5' enhancer
  1. [9] Queen, C. and Baltimore, D., Cell, 33, 741-748 (1983).
  2. [10] Picard, D. and Schaffner, W., Nature, 307, 80-82 (1984).
  3. [11] Stafford, J. and Queen, C., Mol. Cell. Biol., 4, 1042-1049 (1984).
E3' enhancer
  1. [12] Meyer, K.B. and Neuberger, M.S., EMBO J., 8, 1959-1964 (1989).
IGK locus
  1. [13] Folch, G., Jean, C., Ginestoux, C., Giudicelli, V. and Lefranc, M.-P. IMGT overview: the mouse immunoglobulin kappa IGK genes. 19th International Mouse Genome Conference (IMGC), November 5-8, 2005, Strasbourg, France (2005)..