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Citing this page: Lefranc, M.-P. and Lefranc, G., In: Molecular Biology of B cells, pp 37-59 (2004)

House mouse (Mus musculus) IGL locus on chromosome 16 (16A3) at 13cM

The orientation of the mouse (Mus musculus) IGL locus on the chromosome 16 (16A3) at 13cM is reverse (REV).

Locus representation mouse IGL

Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.

Distances are in kb (written in black for distances between genes, in blue for distances between an enhancer and the upstream gene).

The mouse (Mus musculus, Mus spretus) IGLV genes belongs to three subgroups (Gene tables: Mouse IGLV) which are part of three clans (Figure IGLV clans).

Clans comprise, respectively:

  • clan I: IGLV3 subgroup (IGLV4 to IGLV8 genes)
  • clan III: IGLV1 subgroup (IGLV1 and IGLV2 genes)
  • clan V: IGLV2 subgroup (IGLV3 gene)

Locus representation with only the functional genes: House mouse (Mus musculus) IGL

Locus representation mouse IGL

* When needed, indicate the presence of allele(s) with another functionality: see above House mouse (Mus musculus) IGL locus

IMGT references:
  1. [1] Lefranc, M.-P. and Lefranc, G., Immunoglobulin lambda (IGL) genes of human and mouse, In: Molecular Biology of B cells (Honjo, T., Alt, F.W. and Neuberger, M.S. eds) Academic Press, Elsevier Science, pp. 37-59 (2004). 0120536412
IGLV genes
  1. [2] Tonegawa, S. et al., Proc. Natl. Acad. Sci., USA, 75, 1485-1489 (1978).
  2. [3] Arp, B. et al., Nature, 298, 184-187 (1982).
  3. [4] Weiss, S. et al., EMBO J., 6, 927-932 (1987).
  4. [5] Storb, U. et al., Mol. Cell. Biol., 9, 711-718 (1989).
  5. [6] Sanchez, P. et al., J. Immunol., 144, 2816-2820 (1990).
IGLJ segments
  1. [7] Miller, J. et al., Nature, 295, 428-430 (1982).
  2. [8] Bernard, O. et al., Cell, 15, 1133-1144 (1978).
IGLC genes
  1. [9] Selsing, E. et al., Proc. Natl. Acad. Sci. USA, 79, 4681-4685 (1982).
  2. [10] Weiss, S. and Wu, G.E., EMBO J., 6, 927-932 (1987).
  3. [11] Bernard, O. et al., Cell, 15, 1133-1144 (1978).
  4. [12] Mami, F. and Kindt, T.J., J. Immunol., 138, 3980-3985 (1987).
Enhancer
  1. [13] Hagman, J., Genes Dev., 4, 978-992 (1990).
  2. [14] Eccles, S., New Biol., 2, 801-811 (1990).
IGL locus
  1. [15] Folch, G., Scaviner, D. Guiraudou, D., Ginestoux, C., Giudicelli, V., Lefranc G. and Lefranc M.-P. IMGT overview: the mouse immunoglobulin lambda IGL genes. 19th International Mouse Genome Conference (IMGC), November 5-8, 2005, Strasbourg, France (2005). .