The IMGT reference sequences for the polymorphism in the HLAA introns 4, 5, 6 and 7 are selected from [1].
Polymorphisms in the introns 4, 5, 6 and 7 of the HLAA gene, are presented in relation with the HLAA alleles and with the HLAA serological families.
Based on phylogenetic relationship of exons, HLAA serological families can be grouped into two major lineages: the HLAA2 lineage which comprises the A2/A28, A10 and A19 families and the HLAA3 lineage which consists of the A1/A36, A3, A9, A80, A11, A30 and A80 families.
HLAA lineages 
HLAA serological families 
HLAA alleles (1)  

Introns 4, 5, 6 and 7 (2)  IMGT reference sequences (3) 
Sequences from the literature (3) 

HLAA2  A2/A28  A*02  HLAA*02011 (4) 


HLAA*68012 (4)  
A10  A*25  HLAA*2501 (5) 


HLAA*3402 (5)  HLAA*6602  
A19  A*29  HLAA*2901 (6)  HLAA*2902  
HLAA*31012 (6) 


HLAA*3201 (6) 


HLAA3  A1/A36  A*01  HLAA*01011  HLAA*3601  
A3  A*03  HLAA*03011  
A9  A*23  HLAA*2301 


A11  A*11  HLAA*1101 (7)  HLAA*1102 (7)  
A30  A*30  HLAA*3001 (8)  
HLAA*3002 (8)  
HLAA*3004 (8)  
A80  A*80  HLAA*8001 
(nd): not defined serology.
IMGT reference sequences  Intron 4  Intron 5  Intron 6  Intron 7 

HLAA*02011  AJ458204  AJ491722  AJ490827  AJ490942 
HLAA*2501  AJ458226  AJ491744  AJ490849  AJ490964 
HLAA*2901  AJ458228  AJ491746  AJ490851  AJ490966 
HLAA*01011  AJ458203  AJ491721  AJ490826  AJ490941 
HLAA*03011  AJ458214  AJ491732  AJ490837  AJ490952 
HLAA*2301  AJ458217  AJ491735  AJ490840  AJ490955 
HLAA*1101  AJ458215  AJ491733  AJ490838  AJ490953 
HLAA*3001  AJ458230  AJ491748  AJ490853  AJ490968 
HLAA*8001  AJ458250  AJ491767  AJ490873  AJ490988 
(1)  Alleles designations are those used in [1], except for HLAA*2416, which is now designated as HLAA*3108 [3].  
(2)  The nine polymorphisms of the introns 4, 5, 6 and 7 are designated by the two first numbers of the IMGT reference sequence "first" HLAA allele in each serological family. These "first" alleles correspond in the table, to the first line of each serological family.  
(3)  EMBL/GenBank/DDBJ accession numbers from [1] are given for the IMGT reference sequences. Accession numbers of the other sequences are available in [1]. Nucleotide differences between the IMGT reference sequences "first" HLAA alleles and the other IMGT reference sequences are shown in notes (4), (5), (6) and (8). Sequences from the literature refer to alleles whose sequences of the introns 4, 5, 6 and 7 are identical to those of the IMGT reference sequences.  
(4) 


(5) 


(6) 


(7)  Both A*1101 and A*1102 alleles have a nucleotide change in intron 5 (g19>a) which creates a second DONORSPLICE and results in a transcript with an elongated cytoplasmic region [2].  
(8) 

[1]  Elsner, HA. et al., Immunogenetics, 54, 447462 (2002). 
[2]  Tijssen, H.J. et al., Tissue Antigens, 55, 422428 (2000). 
[3]  Marsh S.G.E et al. Tissue Antigens, 60, 407464 (2002). 