Supplementary data 1

The 47 MHC-I and MHC-I-like proteins of our dataset

Receptor type	Species	Protein name	Allele number	Average identity of the allele sequences	Allele used for phylogeny	The alleles with known 3D structure
MHC-I	Homo sapiens	HLA-A	212	90.8% (max 99.5%)	HLA-A*0201	HLA-A0201, HLA-A1101, HLA-A*6801
		HLA-B	428	90.8% (max 99.5%)	HLA-B*0702	HLA-B0801, HLA-B2705 and HLA-B2713, HLA-B2709, HLA-B3501, HLA-B4402, HLA-B4403, HLA-B5101, HLA-B*5301
		HLA-Cw	94	94% (max 99.5%)	HLA-Cw*0701	HLA-Cw0401, HLA-Cw0304
		HLA-E	3	99.3% (max 99.5%)	HLA-E*0101	HLA-E0101, HLA-E0103
		HLA-F	1		HLA-F*0101
		HLA-G	1		HLA-G*0101
	Mus musculus	H2-D	4	83.4% (max 85.3%)	H2-D1*02	H2-D101, H2-D102
		H2-K	7	84.6% (max 89.7%)	H2-K1*01	H2-K102, H2-K103
		H2-L	2	99.5%	H2-L*02	H2-L*02
		H2-M	1		H2-M5*02
		H2-Q	10	78.9% (max 99.5%)	H2-Q7*02	H2-Q7*03
		H2-T	3	67.2% (max 96.7%)	H2-T3*01	H2-T3*02
	Rattus norvegicus	RT1-AA	1		RT1-AA*01	RT1-AA*01
CD1	Homo sapiens	CD1A	1		CD1A*01	CD1A*01
		CD1B	1		CD1B*01	CD1B*01
		CD1C	1		CD1C*01
		CD1D	1		CD1D*01
		CD1E	1		CD1E*01
	Mus musculus	CD1D1	1		CD1D1*01	CD1D1*01
	Rattus norvegicus	CD1D	1		CD1D*01
FCGRT	Homo sapiens	FCGRT	1		FCGRT*01	FCGRT*01
	Mus musculus	FCGRT	1		FCGRT*01
	Rattus norvegicus	FCGRT	1		FCGRT*01	FCGRT*01
	Bos taurus	FCGRT	1		FCGRT*01
HFE	Homo sapiens	HFE	1		HFE*01	HFE*01
	Mus musculus	HFE	1		HFE*01
	Rattus norvegicus	HFE	1		HFE*01
MR1	Homo sapiens	MR1	1		MR1*01
	Mus musculus	MR1	1		MR1*01
	Rattus norvegicus	MR1	1		MR1*01
AZGP1	Homo sapiens	AZGP1	1		AZGP1*01	AZGP1*01
	Mus musculus	AZGP1	1		AZGP1*01
	Rattus norvegicus	AZGP1	1		AZGP1*01
EPCR	Homo sapiens	EPCR	1		EPCR*01	EPCR*01
	Mus musculus	EPCR	1		EPCR*01
	Bos taurus	EPCR	1		EPCR*01
MIC	Homo sapiens	MICA	1		MICA*01	MICA*01
MIC	Homo sapiens	MICB	1		MICB*01	MICB*01
RAE	Homo sapiens	RAET1E	3	97.8% (max 97.8%)	RAET1E*01
		RAET1H	2	99.5%	RAET1H*01
		RAET1I	2	99.5%	RAET1I*01
		RAET1L	2	99.5%	RAET1L*01
		RAET1N	1		RAET1N*01	RAET1N*01
	Mus musculus	RAE1B	1		RAE1B*01	RAE1B*01
	Mus musculus	RAE1G	1		RAE1G*01
	Rattus norvegicus	RAE1B	1		RAE1B*01
	Rattus norvegicus	RAE1G	1		RAE1G*01

The 47 MHC-I and MHC-I-like proteins of our dataset

Receptor type

Species

Protein name

Allele number

Average identity ofthe allele sequences

Allele used for phylogeny

The alleles with known 3D structure

MHC-I

Homo sapiens

HLA-A

212

90.8%(max 99.5%)

HLA-A*0201

HLA-A*0201, HLA-A*1101, HLA-A*6801

HLA-B

428

90.8%(max 99.5%)

HLA-B*0702

HLA-B*0801, HLA-B*2705 and HLA-B*2713, HLA-B*2709, HLA-B*3501, HLA-B*4402, HLA-B*4403, HLA-B*5101, HLA-B*5301

HLA-Cw

94

94%(max 99.5%)

HLA-Cw*0701

HLA-Cw*0401, HLA-Cw*0304

HLA-E

3

99.3%(max 99.5%)

HLA-E*0101

HLA-E*0101, HLA-E*0103

HLA-F

1

HLA-F*0101

HLA-G

1

HLA-G*0101

Mus musculus

H2-D

4

83.4%(max 85.3%)

H2-D1*02

H2-D1*01, H2-D1*02

H2-K

7

84.6%(max 89.7%)

H2-K1*01

H2-K1*02, H2-K1*03

H2-L

2

99.5%

H2-L*02

H2-M

1

H2-M5*02

H2-Q

10

78.9%(max 99.5%)

H2-Q7*02

H2-T

3

67.2%(max 96.7%)

H2-T3*01

Rattus norvegicus

RT1-AA

1

RT1-AA*01

CD1

Homo sapiens

CD1A

1

CD1A*01

CD1B

1

CD1B*01

CD1C

1

CD1C*01

CD1D

1

CD1D*01

Average identity of
the allele sequences

90.8%
(max 99.5%)

HLA-A0201, HLA-A1101, HLA-A*6801

90.8%
(max 99.5%)

HLA-B0801, HLA-B2705 and HLA-B2713, HLA-B2709, HLA-B3501, HLA-B4402, HLA-B4403, HLA-B5101, HLA-B*5301

94%
(max 99.5%)

HLA-Cw0401, HLA-Cw0304

99.3%
(max 99.5%)

HLA-E0101, HLA-E0103

83.4%
(max 85.3%)

H2-D101, H2-D102

84.6%
(max 89.7%)

H2-K102, H2-K103

78.9%
(max 99.5%)

67.2%
(max 96.7%)