Supplementary data 3

The 37 amino acid groups

[1] Pommie,C., Levadoux,S., Sabatier,R., Lefranc,G. and Lefranc,M.-P. (2004) IMGT standardized criteria for statistical analysis of immunoglobulin V-REGION amino acid properties. J. Mol. Recogn., 17, 17-32.

[2] Wu,T.D. and Brutlag,D.L. (1995) Identification of protein motifs using conserved amino acids properties and partitioning techniques. Proc. Thirteenth Int. Conf. Intell. Syst. Mol. Biol., 19, 402-410.


Amino acid group

Reference

Property

IVLFCMAW

[1]

Hydrophobic

DNEQKR

[1]

Hydrophilic

GTSYPH

[1]

Neutral

AGILPV

 

Aliphatic

CDPNT

[1]

Small (108-117 ų)

MILKR

[1]

Large (162-174 ų)

EVQH

[1]

Medium (138-154 ų)

AILV

[1]

Aliphatic

GAS

[1]

Very small (60-90 ų)

FYW

[1,2]

Very large (189-228 ų) and aromatic

ILV

[2]

 

RHK

[1,2]

Basic

DE

[1,2]

Acidic

NQ

[1,2]

Amide

ST

[1,2]

Hydroxyle

CM

[1,2]

Sulfur

AG

[2]

 

P

[1,2]

Proline

F

[1]

Phenylalanine

G

[1]

Glycine

W

[1]

Tryptophan

Y

[1]

Tyrosine

A

 

Alanine

R

 

Arginine

N

 

Asparagine

D

 

Aspartate

C

 

Cysteine

Q

 

Glutamine

E

 

Glutamate

H

 

Histidine

I

 

Isoleucine

L

 

Leucine

K

 

Lysine

M

 

Methionine

S

 

Serine

T

 

Threonine

V

 

Valine