IMGT Repertoire (IG and TR)

truncated pseudogene not assigned to subgroups with functional genes
No L-PART1, frameshift in V-REGION: several insertions and deletions
STOP-CODON in L-PART1
no L-PART1, frameshift in FR1-IMGT: insertion of 16 nt
no L-PART1, no L-PART2
STOP-CODON in L-PART1, frameshifts in V-REGION: several insertions and deletions
frameshift in L-PART1 causing defectuous DONOR-SPLICE, frameshifts in V-REGION: several insertions and deletions
no L-PART1, frameshifts in V-REGION: several insertions and deletions
no L-PART1, frameshift in V-REGION: insertion of 16 nt in FR1-IMGT
no L-PART1, no L-PART2, truncated pseudogene not assigned to subgroups with functional genes
no L-PART1, no L-PART2, no L-PART2, truncated pseudogene not assigned to subgroups with functional genes
frameshift in V-REGION: several insertions and deletions
frameshifts in V-REGION: several insertions and deletions
no L-PART1, frameshift in V-REGION: deletion of 1 nt in CDR1-IMGT
no L-PART1, no L-PART2, truncated pseudogene not assigned to subgroups with functional genes, frameshift in V-REGION: deletion of 1 nt in CDR1-IMGT
no L-PART1, no L-PART2, frameshifts in V-REGION: several insertions and deletions
No L-PART1, frameshift in L-PART2, frameshift in V-REGION: several insertions and deletions, No V-RS
no L-PART1+frameshift in L-PART2+too many frameshifts+no V-RS
STOP-CODON in FR1-IMGT, frameshift in V-REGION: several insertions and deletions in FR3-IMGT, no V-NONAMER
STOP-CODON in FR1-IMGT: position 1 and 15, frameshift in V-REGION: several insertions and deletions in FR3-IMGT
no INIT-CODON: Ile instead of Met, no ACCEPTOR-SPLICE, frameshifts in V-REGION: several insertions and deletions
No L-PART1, deletion of 24 nt in V-REGION, frameshift in V-REGION: several insertions and deletions
frameshift in V-REGION: several insertions and deletions, no V-NONAMER
frameshift in L-PART1: deletion of 1 nt causing defectuous DONOR-SPLICE, frameshifts in V-REGION: several insertions and deletions
No L-PART1, frameshift in V-REGION: several insertions and deletions, no V-NONAMER
No L-PART1, No L-PART2, frameshift in V-REGION: several insertions and deletions, no V-NONAMER
no INIT-CODON: Leu instead of Met, STOP-CODON in L-PART1, frameshift in V-REGION: insertion of 8 nt in FR1-IMGT
no L-PART1, no L-PART2, truncated pseudogene not assigned to subgroups with functional genes, no V-NONAMER
several STOP-CODON in V-REGION, frameshifts in V-REGION: several insertions and deletions
L-PART1 not found, frameshifts in FR3-IMGT
no INIT-CODON: Val instead of Met, frameshift in L-PART1:deletion of 1 nt causing defectuous DONOR-SPLICE, frameshift in V-REGION: insertion of 2 nt in FR3-IMGT
no L-PART1, truncated pseudogene not assigned to subgroups with functional genes, no V-RS
frameshifts in V-REGION, L-PART1 not found
no DONOR-SPLICE, frameshift in V-REGION: deletion of 2 nt in FR1-IMGT
frameshift in L-PART1 causing defectuous DONOR-SPLICE, no L-PART2, truncated pseudogene not assigned to subgroups with functional genes
frameshift in L-PART1 causing defectuous DONOR-SPLICE, no L-PART2, no L-PART2, truncated pseudogene not assigned to subgroups with functional genes
Frameshift in L-PART1, frameshift in V-REGION: several insertions and deletions, no V-RS
no L-PART2, truncated pseudogene not assigned to subgroups with functional genes, no V-NONAMER
no L-PART1, no L-PART2, truncated pseudogene not assigned to subgroups with functional genes, truncated pseudogene not assigned to subgroups with functional genes, no V-RS
no L-PART1, no L-PART2, no L-PART2, truncated pseudogene not assigned to subgroups with functional genes, truncated pseudogene not assigned to subgroups with functional genes, no V-RS,
frameshift in L-PART2, no L-PART1, truncated pseudogene not assigned to subgroups with functional genes, no V-RS, no V-RS
V-CLUSTER: A.
V-CLUSTER: B.
V-CLUSTER: C.
frameshift in L-PART1, frameshift in L-PART2, frameshift in V-REGION: several insertions and deletions, no V-RS.
IGLV(IV)-66-1 has been identified in D87004 by IMGT curators (Folch, G., Giudicelli, V. and Lefranc, M.-P., IMGT On-line, 14/12/1999).
An additional vestigial pseudogene lambdavg3, which has 92% identity with lambdavg2 has been identified in D86994 by IMGT curators (N. Bosc, M.-P. Lefranc), between IGLV3-25 and IGLV3-26 (5.7kb downstream from IGLV3-26). The lambdavg2 and lambdavg3 sequences define a new clan IGLV(VI) and are designated as IGLV(VI)-22-1 (X71351)[18] and IGLV(VI)-25-1 (D86994)[26], respectively.
The highly diverged vestigial pseudogene lambdavgl (X99568)[5] has no CONSERVED_TRP and no 2nd_CYS (confirmed with D86999[26] although this accession number contains many sequencing or typing errors). Since this lambdavg1 sequence is unique in the human genome and can therefore be used as a STS (Sequence Tagged Site)[5] , the lambdavg1 was attributed to a new clan IGLV(VII) and designated as IGLV(VII)-41-1.

IMGT references: ↑

Alexandre D. et al., First genomic sequence of a human Ig variable lambda gene belonging to subgroup I. Functional genes, pseudogenes and vestigial sequences are interspersed in the IGLV locus, Nucleic Acids Res, vol. 17, no. 10, 1989, pp. 3975-3975. DOI: 10.1093/nar/17.10.3975
Chuchana P. et al., The IGLVA gene as a STS in the human immunoglobulin lambda light chain variable gene locus (located at 22q11), Nucleic Acids Res, vol. 19, no. 17, 1991, pp. 4786-4786. DOI: 10.1093/nar/19.17.4786
Chu et al., Approaching an Error-Free Diploid Human Genome Assembly of East Asian Origin, (misc) bioRxivorg, 2025, DOI: 10.1101/2025.08.01.667781
Chu et al., Direct Submission, Computational Biology, Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation. Submitted (16-AUG-2025). NGDC, Beijing, 100101, China.
Cole,C.G. et al., Finishing the finished human chromosome 22 sequence, Genome Biol, vol. 9, no. 5, 2008, pp. R78-.
Frippiat J.P. and Lefranc M.P, Genomic organisation of 34 kb of the human immunoglobulin lambda locus (IGLV): restriction map and sequences of new V lambda III genes, Mol. Immunol, vol. 31, no. 9, 1994, pp. 657-670. DOI: 10.1016/0161-5890(94)90175-9
He et al., T2T YAO: A Telomere to telomere Assembled Diploid Reference Genome for Han Chinese, Genomics Proteomics & Bioinformatics 21(6): 1085–1100 (2023), DOI: 10.1016/j.gpb.2023.08.001
Kawasaki K. et al., One-megabase sequence analysis of the human immunoglobulin lambda gene locus, Genome Res, vol. 7, no. 3, 1997, pp. 250-261. PUBMED: 9074928
Lander,E.S. et al., Initial sequencing and analysis of the human genome, International Human Genome Sequencing Consortium Nature, vol. 409, no. 6822, 2001, pp. 860-921.
Nurk S. et al., The complete sequence of a human genome, Science, vol. 376, no. 6588, 2022, pp. 44-53. PUBMED: 35357919
Rodriguez,O.L. et al., An ethnically diverse genomic reference resource for human immune receptor gene loci, Unpublished.
Rodriguez O.L. et al., An ethnically diverse genomic reference resource for human immune receptor gene loci, Unpublished.

IMGT Repertoire (IG and TR)

Dynamic gene tables per IMGT group and per species (IMGT/GeneTables)

Gene table legend:

IMGT notes: ↑

IMGT references: ↑

IMGT Repertoire (IG and TR)

Dynamic gene tables per IMGT group and per species (IMGT/GeneTables)

Version 1.4

Version 1.3

Version 1.2

Version 1.1

Version 1.0

Gene table legend:

IMGT notes: ↑

IMGT references: ↑