IMGT Repertoire (IG and TR)

frameshifts in V-REGION, no L-PART1, non canonical V-HEPTAMER: tatttat instead of cacagtg and non canonical V-NONAMER: acgtaaatc instead of tcagaaacc
no L-PART1, frameshifts in V-REGION and no V-RS
no CONSERVED-TRP: STOP-CODON instead of Trp, frameshift in V-REGION: deletion of 1 nt in FR2-IMGT, no V-HEPTAMER
insertions in V-REGION (10 AA are added), STOP-CODON at position 106 (last 3' codon of germline CDR3-IMGT) may disappear during rearrangements
insertions in V-REGION: 10 AA are added, STOP-CODON at position 106 (last 3' codon of germline CDR3-IMGT) may disappear during rearrangements
frameshift in V-REGION, no L-PART1, no V-RS
no L-PART1, frameshifts in V-REGION, non canonical ACCEPTOR-SPLICE: natnn instead of nagnn and no V-RS in 3'UTR
no L-PART1, several STOP-CODON in V-REGION, no V-RS
no L-PART1, frameshifts in V-REGION: several insertions and deletions, no V-RS
INIT-CODON is replaced by Tyr and 1st-CYS is replaced by in frame STOP-CODON
STOP-CODON in L-PART1
frameshifts in V-REGION
frameshifts in V-REGION: several insertions and deletions
deletion in L-PART1 (1 nt is missing) and in frame STOP-CODON in FR1-IMGT
frameshift in L-PART1
frameshift in L-PART1, frameshift in L-PART2
in frame STOP-CODON in L-PART1
CONSERVED-TRP is replaced by Cys and non canonical DONOR-SPLICE: ngc instead of ngt
noncanonical DONOR-SPLICE: ngc instead of ngt, no CONSERVED-TRP: Cys instead of Trp
INIT-CODON is replaced by Ile and frameshifts in V-REGION
no INIT-CODON: Ile instead of Met, frameshift in V-REGION: deletion of 1 nt in FR1-IMGT
INIT-CODON is replaced by Arg
no INIT-CODON: Phe instead of Met, STOP-CODON in V-REGION: position 5, frameshift in V-REGION: deletion of 1 nt in FR1-IMGT
frameshift in L-PART1, frameshift in V-REGION: deletion of 5 nt in FR2-IMGT
STOP-CODON in V-REGION: position 55, frameshift in V-REGION: insertion of 2 nt in FR3-IMGT
STOP-CODON in L-PART1, several STOP-CODON in V-REGION
no INIT-CODON: Arg instead of Met
no INIT-CODON: Ile instead of Met, STOP-CODON in V-REGION: position 8, frameshift in V-REGION: deletion of 1 nt in FR3-IMGT
STOP-CODON in V-REGION: position 12, frameshifts in V-REGION: several insertions
frameshift in V-REGION: insertion of 14 nt in FR3-IMGT
STOP-CODON in V-REGION: position 107
no CONSERVED-TRP: STOP-CODON instead of Trp
STOP-CODON in V-REGION: position 54
no INIT-CODON: Ile instead of Met
no INIT-CODON: Ile instead of Met, several STOP-CODON in V-REGION, frameshifts in V-REGION: deletion of 2 nt and 1 nt in FR1-IMGT
no INIT-CODON: Ile instead of Met, STOP-CODON in V-REGION: position 5, frameshift in V-REGION: deletion of 1 nt in FR1-IMGT
no 1st-CYS: Ser instead of Cys
frameshift in L-PART1, STOP-CODON in V-REGION: position 5, frameshifts in V-REGION: several deletions
frameshift in L-PART1, several STOP-CODON in V-REGION, frameshifts in V-REGION: several insertions and deletions
STOP-CODON in V-REGION: position 52, frameshift in V-REGION: deletion of 2 nt in FR3-IMGT
STOP-CODON in L-PART1, STOP-CODON in V-REGION: position 5, frameshifts in V-REGION: several deletions
frameshift in L-PART2
several STOP-CODON in V-REGION
no L-PART1, several STOP-CODON in V-REGION
STOP-CODON in V-REGION: position 59
STOP-CODON in V-REGION: position 51
frameshift in L-PART1, several STOP-CODON in V-REGION
no V-NONAMER
STOP-CODON in V-REGION: position 67, frameshift in V-REGION: deletion of 1 nt in FR3-IMGT
STOP-CODON in V-REGION: position 51, frameshift in V-REGION: deletion of 7 nt in FR3-IMGT
STOP-CODON in V-REGION: position 11
no 1st-CYS: Phe instead of Cys
noncanonical DONOR-SPLICE: ntt instead of ngt, noncanonical V-NONAMER: tataaatac instead of tcagaaacc
no INIT-CODON: Ile instead of Met, STOP-CODON in V-REGION: position 54
frameshift in L-PART1, frameshift in V-REGION: deletion of 2 nt in FR3-IMGT
STOP-CODON in L-PART1, frameshift in V-REGION: deletion of 5 nt in FR1-IMGT
frameshift in V-REGION: deletion of 1 nt in FR1-IMGT
no 2nd-CYS: Ser instead of Cys
no INIT-CODON: Ile instead of Met, STOP-CODON in V-REGION: position 67
no 2nd-CYS: Phe instead of Cys
no INIT-CODON: Ile instead of Met, frameshifts in V-REGION: several insertions and deletions
no INIT-CODON: Ile instead of Met, frameshift in V-REGION: deletion of 1 nt in FR2-IMGT
noncanonical DONOR-SPLICE: ntt instead of ngt, no 2nd-CYS: Arg instead of Cys
no INIT-CODON:Ile instead of Met
noncanonical V-NONAMER: tagaaatac instead of cagaaaacc, noncanonical DONOR-SPLICE: ntt instead of ngt
frameshifts in V-REGION: several insertions and deletions, frameshift in L-PART1: deletion of 4 nt causing defectuous DONOR-SPLICE
STOP-CODON in V-REGION: position 37
no INIT-CODON: Ile instead of Met, several STOP-CODON in V-REGION
no V-RS
frameshift in V-REGION: deletion of 1 nt in FR3-IMGT
frameshift in V-REGION: deletion of 2 nt in FR3-IMGT
no DONOR-SPLICE, STOP-CODON in V-REGION: position 51
non canonical V-HEPTAMER but this V-GENE has been found rearranged
CONSERVED-TRP is replaced by in frame STOP-CODON
in frame STOP-CODON in CDR1-IMGT and 2nd-CYS is replaced by Ser
CONSERVED-TRP is replaced by Cys
CONSERVED-TRP is replaced by Cys, non canonical DONOR-SPLICE: ngc instead of ngt and non canonical V-HEPTAMER: tattgct instead of cacagct
INIT-CODON is replaced by Ile, in frame STOP-CODON in FR2-IMGT and CONSERVED-TRP is replaced by Leu
INIT-CODON is replaced by Ile, in frame STOP-CODON in FR1-IMGT and non canonical DONOR-SPLICE: nat instead of ngt
in frame STOP-CODON in FR2-IMGT, 1st-CYS is replaced by Phe and 2nd-CYS is replaced by Phe
frameshifts in V-REGION, deletion in L-PART1 (1 nt is missing) and non canonical ACCEPTOR-SPLICE: natnn instead of nagnn
in frame STOP-CODON in L-PART1, in frame STOP-CODON in CDR1-IMGT and 1st-CYS is replaced by Ser
Pseudogene due to a DELETION of 1 nucleotide in the FR2-IMGT
no CONSERVED-TRP: Cys instead of Trp
in frame STOP-CODON in FR2-IMGT, non canonical DONOR-SPLICE: nca instead of ngt and 2nd-CYS is replaced by Arg
Pseudogene due to a STOP-CODON in FR2-IMGT and Conserved-Cys is replaced by Arg
Pseudogene due to a STOP-CODON in frame (positions 236-238) in the FR2-IMGT
no 2nd-CYS: Arg instead of Cys, noncanonical V-HEPTAMER: ctcagtt instead of cacagtg
noncanonical DONOR-SPLICE: ngg instead of ngt
frameshifts in V-REGION, in frame STOP-CODON in L-PART1 and non canonical DONOR-SPLICE: ntt instead of ngt
Pseudogene because of frameshifts in V-REGION.
frameshifts in V-REGION: several deletions
frameshift in V-REGION: insertion of 1 nt in FR3-IMGT
Pseudogene due to a STOP-CODON in frame (positions 957-959) at codon 89 in FR3-IMGT
frameshift in V-REGION: insertion of 1 nt in FR2-IMGT
frameshift in V-REGION: deletion of 1 nt in CDR1-IMGT
frameshift in V-REGION: insertion of 1 nt in FR1-IMGT
Pseudogene because of in frame STOP-CODON in V-REGION.
noncanonical V-NONAMER: tccgaaaat instead of tcagaaacc
STOP-CODON in V-REGION: position 102
no L-PART2, STOP-CODON in V-REGION: position 3, frameshifts in V-REGION: several deletions
STOP-CODON in V-REGION: position 44
noncanonical V-NONAMER: tcaaaaata instead of tcagaaacc
STOP-CODON in V-REGION: position 52
no 2nd-CYS: Gly instead of Cys
no INIT-CODON: Arg instead of Met, frameshifts in V-REGION: several insertions and deletions
noncanonical V-NONAMER: ccgaaaacc instead of tcagaaacc
frameshift in V-REGION: deletion of 1 nt in FR2-IMGT
in frame STOP-CODON in FR1-IMGT and non canonical DONOR-SPLICE: ngg instead of ngt
in frame STOP-CODON in V-REGION at positions AA 41 and 54
noncanonical DONOR-SPLICE: ngg instead of ngt, unexpected V-SPACER length: 10 nt instead of 23 nt
noncanonical ACCEPTOR-SPLICE: nggnn instead of nagnn
no L-PART1, no L-PART2, frameshifts in V-REGION: several insertions and deletions
Pseudogene because no INIT-CODON in the L-PART1 (ATG is replaced by ACG)
CONSERVED-TRP is replaced by in frame STOP-CODON and in frame STOP-CODON in FR2-IMGT
frameshifts in V-REGION.
frameshifts in V-REGION, putative limit in 3' of V-REGION, non canonical DONOR-SPLICE: ngg instead of ngt and no V-RS in 3'UTR
INIT-CODON is replaced by Ile
in frame STOP-CODON in FR2-IMGT
several STOP-CODON in V-REGION, frameshift in V-REGION: deletion of 1 nt in FR3-IMGT
STOP-CODON in V-REGION: position 3, frameshifts in V-REGION: several insertions and deletions, no V-RS
Reference sequence: V102
non canonical V-NONAMER, however this V-GENE has been found rearranged
in frame STOP-CODON in FR1-IMGT
In frame STOP-CODON (positions 300-302) at codon 44 in FR2-IMGT
pseudogene due to a STOP-CODON in frame (positions 300-302) in the FR2-IMGT.
Pseudogene due to a STOP-CODON in frame instead of conserved-Trp in FR2-IMGT
Pseudogene due to a STOP-CODON in frame in FR2_IMGT
Pseudogene due to no INIT-CODON in L-PART1
Pseudogene due to a STOP-CODON in frame in FR1-IMGT
Pseudogene due to a STOP-CODON in frame in FR2-IMGT
Strain A/J
In frame STOP-CODON (positions 530-532) at codon 90 in FR3-IMGT
Pseudogene due to a STOP-CODON in frame (positions 375-377) in FR2-IMGT
Pseudogene due to a DELETION of 1 nucleotide (g between positions 395/396) in FR2-IMGT leading a frameshift
Pseudogene due to a STOP-CODON in frame at codon 54 in FR2-IMGT
Pseudogene due to a STOP-CODON in frame at codon 67 in FR3-IMGT
Pseudogene because of the Conserved-Trp is replaced by a STOP-CODON
Pseudogene due to a STOP-CODON in frame at codon 27 in CDR1-IMGT
partial FR3-IMGT (AA 93 to 104 are absent) and no CDR3-IMGT
partial FR3-IMGT (AA 93 to 104 are absent), no CDR3-IMGT
truncated pseudogene
Reference sequence: VH101
in frame STOP-CODON in CDR1-IMGT
truncated gene, insertion of 7247kbs between IGHV2-7*02 (part 5') and IGHV2-7*02 (part 3')
frameshift in L-PART2, frameshift in V-REGION: deletion of 2 nt in FR1-IMGT
no L-PART1, no L-PART2, frameshift in V-REGION: deletion of 1 nt in FR2-IMGT
STOP-CODON at position 106 (last 3' codon of germline V-REGION) may disappear during rearrangements
in frame STOP-CODON in V-REGION at position AA 51
in frame STOP-CODON in FR3-IMGT
in frame STOP-CODON in V-REGION
STOP-CODON in V-REGION: position 67
several STOP-CODON in V-REGION, deletions in V-REGION: AA 105 to 115 are missing, no V-RS
STOP-CODON in V-REGION: position 38, deletions in V-REGION: AA 100 to 115 are missing, no V-RS
frameshift in V-REGION and no V-RS
no CONSERVED-TRP: STOP-CODON instead of Trp, several STOP-CODON in V-REGION, no V-RS
frameshifts in V-REGION and no V-RS in 3'UTR
frameshifts in V-REGION: several insertions and deletions, no V-RS
STOP-CODON in L-PART2, frameshift in V-REGION: deletion of 2 nt in CDR1-IMGT, no V-RS
STOP-CODON in V-REGION: position 75
Reference sequence: VH283
several STOP-CODON in V-REGION, deletions in V-REGION: AA 101 to 115 are missing, no V-RS
in frame STOP-CODON in CDR1-IMGT, in frame STOP-CODON in FR3-IMGT and no V-RS in 3'UTR
frameshift in L-PART1, frameshift in V-REGION: deletion of 1 nt in CDR1-IMGT
STOP-CODON in V-REGION: position 38
in frame STOP-CODON in L-PART1 and frameshifts in V-REGION
in frame STOP-CODON in L-PART1, frameshifts in V-REGION and no V-RS
frameshift in V-REGION: deletion of 1 nt in FR1-IMGT, no V-RS
frameshift in L-PART1, frameshift in V-REGION: deletion of 8 nt in CDR1-IMGT
frameshift in V-REGION: deletion of 8 nt in CDR1-IMGT
in frame STOP-CODON in FR3-IMGT and frameshift in L-PART1
frameshift in L-PART1, frameshift in V-REGION, no V-RS
frameshift in L-PART1, several STOP-CODON in V-REGION, no V-RS
in frame STOP-CODON in L-PART1, frameshifts in V-REGION and no V-RS in 3'UTR
no L-PART1 and frameshifts in V-REGION
no INIT-CODON: Ile instead of Met, STOP-CODON in L-PART1, STOP-CODON in L-PART2, STOP-CODON in V-REGION: position 44, frameshifts in V-REGION: several insertions and deletions, no V-RS
no INIT-CODON: Ile instead of Met, STOP-CODON in L-PART1, STOP-CODON in L-PART2, frameshifts in V-REGION: several insertions and deletions, no V-RS
noncanonical V-NONAMER: ccaccaacc instead of tcaaaaacc
non canonical V-HEPTAMER: cacagta instead of cacagtg and non canonical V-NONAMER: ccaccaacc instead of tcagaaaac
noncanonical DONOR-SPLICE: ngc instead of ngt
non canonical DONOR-SPLICE: ngc instead of ngt
noncanonical V-NONAMER: ccaccaacc instead of tcagaaacc
deletion in V-SPACER (17 nt instead of 23 nt)
frameshifts in V-REGION, in frame STOP-CODON in L-PART1 and non canonical DONOR-SPLICE: naa instead of ngt
STOP-CODON in L-PART1, no DONOR-SPLICE, several STOP-CODON in V-REGION, frameshift in V-REGION: deletion of 1 nt in FR3-IMGT
2nd-CYS is replaced by Gly
noncanonical V-NONAMER: gcaatattt instead of acaaaaatt
frameshift in V-REGION: deletion of 4 nt in FR1-IMGT, no V-RS
frameshift in V-REGION: deletion of 4 nt in FR1-IMGT, deletions in V-REGION: AA 105 to 107 are missing, no V-HEPTAMER
non canonical V-NONAMER: gcaatagtt instead of tcagaaacc
STOP-CODON in V-REGION: position 14, frameshift in V-REGION: deletion of 4 nt in FR3-IMGT
STOP-CODON at position 106 (last (or penultimate) 3’ codon of germline CDR3-IMGT) may disappear during rearrangements, noncanonical V-HEPTAMER: cgcattg instead of cacagtg, noncanonical V-NONAMER: acagtaatt instead of tcagaaacc
no L-PART1
noncanonical V-NONAMER:acagtatt instead of tcagaaacc
frameshift in L-PART1, several STOP-CODON in V-REGION, no CONSERVED-TRP: STOP-CODON instead of Trp
STOP-CODON in L-PART1, STOP-CODON in V-REGION: position 13, frameshift in V-REGION: deletion of 4 nt in FR3-IMGT
frameshift in V-REGION: deletion of 4 nt in FR3-IMGT
noncanonical V-HEPTAMER: catattg instead of cacagtg
noncanonical V-NONAMER: acattattt instead of acaaaaatt
noncanonical V-HEPTAMER: cacgttg instead of cacaatg, noncanonical V-NONAMER: aaactattt instead of tagaaatac
noncanonical V-HEPTAMER: cacgttg instead of cacagtg, noncanonical V-NONAMER: aaactattt instead of tagaaatac
STOP-CODON at position 106 (last (or penultimate) 3’ codon of germline CDR3-IMGT) may disappear during rearrangements, noncanonical V-NONAMER: acagtattt instead of tagaaatac
noncanonical V-NONAMER: atagtaatt instead of acataaacc
noncanonical V-HEPTAMER:cacgttg instead of cacaatg, noncanonical V-NONAMER:aaagtattt instead of acaaaaatt
noncanonical V-HEPTAMER: cacgttg instead of cacagtg, noncanonical V-NONAMER: aaagtattt instead of acaaaaatt
no INIT-CODON: Thr instead of Met
2nd-CYS is replaced by Ser
in frame STOP-CODON in FR1-IMGT and in frame STOP-CODON in CDR3-IMGT
frameshifts in V-REGION: several insertions and deletions, deletions in V-REGION: AA 103 to 106 are missing
STOP-CODON in V-REGION: position 110
no L-PART1, several STOP-CODON in V-REGION, no CONSERVED-TRP: STOP-CODON instead of Trp, frameshifts in V-REGION: several insertions and deletions
in frame STOP-CODON in FR1-IMGT, in frame STOP-CODON in CDR3-IMGT and CONSERVED-TRP is replaced by Cys
frameshift in L-PART1, no L-PART2, deletions in V-REGION: AA 1 to 14 are missing, no CONSERVED-TRP: STOP-CODON instead of Trp, several STOP-CODON in V-REGION
no CONSERVED-TRP: STOP-CODON instead of Trp, several STOP-CODON in V-REGION
Pseudogene due to DELETIONs in the FR2-IMGT and in the CDR2-IMGT leading to frameshifts
Pseudogene due to a STOP-CODON in the FR2-IMGT
noncanonical ACCEPTOR-SPLICE: tattc instead of nagnn, however this gene has been found rearranged
no L-PART1, frameshift in V-REGION: deletion of 8 nt in FR1-IMGT
no L-PART1, STOP-CODON in V-REGION: position 11, frameshift in V-REGION: deletion of 8 nt in FR1-IMGT
frameshift in V-REGION, no L-PART1
no L-PART1, frameshift in FR3-IMGT
in frame STOP-CODON in the FR1-IMGT and 2nd-CYS is replaced by Tyr
in frame STOP-CODON in FR1-IMGT and in frame STOP-CODON in CDR2-IMGT
frameshift in L-PART1, STOP-CODON in V-REGION: position 3
STOP-CODON in V-REGION: position 17
noncanonical DONOR-SPLICE: nat instead of ngt
in frame STOP-CODON in FR1-IMGT and 2nd-CYS is replaced by Tyr
frameshift in V-REGION
CONSERVED-TRP is replaced by Arg and 2nd-CYS is replaced by Tyr
Unproductive due to an INSERTION of 1 bp in FR1-IMGT and an INSERTION of 1 bp in FR3-IMGT leading to frameshifts
deletion in L-PART1 (1 nt is missing)
2nd-CYS is replaced by Trp
in frame STOP-CODON in FR1-IMGT and CONSERVED-TRP is replaced by STOP-CODON
no L-PART1, no V-RS
no L-PART1, no L-PART2, frameshifts in V-REGION and no V-RS in 3'UTR
no L-PART1, no L-PART2, truncated pseudogene, no V-RS
non canonical DONOR-SPLICE, however this V-GENE has been found rearranged
non canonical V-NONAMER: acaaaaccc instead of actaaaacc
frameshift in V-REGION: deletion of 2 nt in FR2-IMGT
Two potential gene and alleles, IGHV1-55*01 and IGHV1-9*01, correspond to V165.1, based on IMGT/V-QUEST analysis of rearranged IMGT/LIGM-DB sequences (V. Giudicelli, G. Folch, J. Jabado-Michaloud, M.-P. Lefranc (09/12/15)).
Partial V-REGION: partial FR3-IMGT (AA 93 to 104 are absent), no CDR3-IMGT. These sequences were isolated from liver genomic DNA. Most of these sequences are probably germline but some could be from B cells rearranged sequences. In order to assess the level of B lymphocyte contamination in liver, quantative PCR assay was performed. The level of rearranged templates in liver DNA is about one rearranged VH186.2-related gene for every 1000-4000 unrearranged VH186.2-related templates (Rothenfluh in Ph.D thesis) citation in [53]. Based on this observation, the authors consider that their sequences are germline.
Partial V-REGION: partial FR1-IMGT (AA 1 to 3 are absent) and partial FR3-IMGT (AA 100 to 104 are absent).
One gene and allele IGHV1-52*01 seem to correspond to CH10, based on IMGT/V-QUEST analysis of rearranged IMGT/LIGM-DB sequences (V. Giudicelli, G. Folch, J. Jabado-Michaloud, M.-P. Lefranc (09/12/15)).
Two potential genes and alleles, IGHV1-64*01 and IGHV1-72*01, seem to correspond to C1H4, based on IMGT/V-QUEST analysis of rearranged IMGT/LIGM-DB sequences (V. Giudicelli, G. Folch, J. Jabado-Michaloud, M.-P. Lefranc (09/12/15)).
Sterile transcript.
Partial V-REGION: partial FR1-IMGT (AA 1 to 3 are absent).
In frame STOP-CODON (positions 309-311) at codon 41 instead of the CONSERVED-TRP in FR2-IMGT.
The sequence described in the manuscript is different from the one submitted to the EMBL data library. Nucleotide a at position 261 in EMBL flat file (codon 11 in FR1-IMGT), nucleotide g in the manuscript.
DELETION of 1 nucleotide (between positions 787/788) in FR2-IMGT.
L26866 and J00535 are mentioned as identical in Weiller et al. [69], the nucleotide t missing between positions 63/64 in L26866 EMBL flat file seems to be a typing error.
ORF because of no CONSERVED-TRP.
Four nucleotides of the V-REGION of the V104A sequence from Givol et al. [22] were corrected by Blankestein et al. [5]. Nucleotides gc at positions 1096-1097 in EMBL flat file are replaced by nucleotides ca (g148>c, c149>a, A55>Q in the IMGT unique V-REGION numbering), nucleotide g at position 1111 is replaced by nucleotide a (g163>a, G60>S in CDR2-IMGT) and nucleotide c at position 1132 is replaced by g (c184>g, Q69>E in FR3-IMGT).
In frame STOP-CODON (positions 1031-1033) at codon 102 in FR3-IMGT, and non canonical V-HEPTAMER: cacagcg instead of cacagtg.
Partial V-REGION: partial FR1-IMGT (AA 1 to 16 are absent).
Partial V-REGION: partial FR1-IMGT (AA 1 to 16 are absent) and partial FR3-IMGT (AA 100 to 104 are absent).
Partial V-REGION: partial FR1-IMGT (AA 1 to 16 are absent) and partial FR3-IMGT (AA 98 to 104 are absent). This sequence differs by 2 nucleotides from K02154 and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
Partial V-REGION: partial FR3-IMGT (AA 100 to 104 are absent).
No INIT-CODON in L-PART1.
Partial V-REGION: partial FR1-IMGT (AA 1 to 3 are absent) and partial FR3-IMGT (AA 81 to 104 are absent).
Partial V-REGION: partial FR1-IMGT (AA 1 to 11 are absent).
Sterile transcript, partial V-REGION: partial FR1-IMGT (AA 1 to 3 are absent) and partial FR3-IMGT (AA 81 to 104 are absent).
Partial V-REGION: partial FR1-IMGT (AA 1 to 10 are absent).
M34984 differs from M34983 by two additional nucleotides (nucleotides ga) at the end of the CDR3-IMGT.
In frame STOP-CODON (positions 851-853) at codon 54 in FR2-IMGT.
No INIT-CODON in L-PART1, and non canonical V-HEPTAMER: gacagtg instead of cacagtg.
In frame STOP-CODON (positions 62-64) at codon 1 in FR1-IMGT.
This sequence differs by 1 nucleotide from L33936 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
CONSERVED-TRP is replaced by a STOP-CODON.
This sequence differs by 1 nucleotide from X03399
Second part is localized from 482458..482621 after an insertion of 7247kbs
Partial V-REGION: partial FR3-IMGT (AA 92 to 104 are absent), no CDR3-IMGT.
Non canonical V-HEPTAMER: cacattg instead of cacagtg.
Partial V-REGION: partial FR3-IMGT (AA 102 to 104 are absent), no CDR3-IMGT.
The nucleotide c at position 271 in the EMBL flat file is a typing error because this nucleotide is a g in the manuscript (c271>g in the IMGT unique V-REGION numbering.)
The nucleotide c at position 271 in the EMBL flat file is a typing error because this nucleotide is a g in the manuscript (c271>g in the IMGT unique V-REGION numbering.) This sequence differs by 1 nucleotide from K02791 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
These sequences were isolated from liver genomic DNA by PCR using a sense FR1 primer and a FR3 antisense primer. They are probably germline but this needs to be confirmed with a germline sequence.
This sequence differs by 1 nucleotide from M34983 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
Partial V-REGION: partial FR1-IMGT (AA 1 to 12 are absent).
Partial V-REGION: partial FR1-IMGT (AA 1 to 23 are absent).
This sequence differs by 4 nucleotides from K02890 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
Partial V-REGION: partial FR1-IMGT (AA 1 to 24 are absent).
This sequence differs by 1 nucleotide from X03400 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
This sequence differs by 5 nucleotides from X67409 in the V-REGION and is temporarily considered as an allele of this sequence, these data need to be confirmed with a germline sequence.
Partial V-REGION: partial CDR2-IMGT and no FR3-IMGT.
Partial V-REGION: partial FR1-IMGT (AA 3 to 5 are absent ), partial FR3-IMGT (AA 67 to 104 are absent).
J00538 is a sequence constructed from data of 4 different sources. Positions 443-856 correspond to the germline sequence from V00758. Other parts of the sequence are derived from rearranged clones and need to be confirmed by genomic germline data.
V00758 is also part of J00538 (positions 443-856) which is a sequence constructed from data of 4 different sources. See note (90).
The nucleotides c at position 151 and g at position 292 in the J00524 EMBL flat file are typing errors (c151>g and g292>c). The sequences J00500 and J00524 are identical.
This sequence is mentioned as identical to the V3 sequence from Crews et al. [14], in Siu et al. [62], the nucleotide a at position 773 in the M16724 EMBL flat file (instead of g, in J00504 Crews et al. [14]) may represent a typing error.
The nucleotides t at position 140, t at position 144 and a at position 145 in the J00526 EMBL flat file seem to be typing errors (t140>c, t144>a, a145>g).
Partial V-REGION: partial FR3-IMGT (AA 103 to 104 are absent), no CDR3-IMGT.
Partial V-REGION: partial FR3-IMGT (AA 104 is absent), in frame STOP-CODON at codon 103 in FR3-IMGT.
Partial V-REGION: partial FR3-IMGT (AA 103 to 106 are absent), in frame STOP-CODON (positions 146-148) at codon 52 in FR2-IMGT.
Partial V-REGION: partial CDR3-IMGT (AA 105 to 106 are absent). This sequence differs by 1 nucleotide from Z15022 and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
Partial V-REGION: partial CDR3-IMGT (AA 105 to 106 are absent).
Partial V-REGION: partial FR1-IMGT (AA 1 to 3 are absent), partial CDR3-IMGT (AA 105 to 106 are absent).
Partial V-REGION: partial FR1-IMGT (AA 1 to 2 are absent), no CDR3-IMGT.
This sequence differs by 3 nucleotides from AF064443 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
This sequence differs by 2 nucleotides from AF064442 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
This sequence differs by 1 nucleotide from the putative germline sequence from Chao et al. (PMID: 1557050).
This sequence is identical to the putative germline sequence from Chao et al. (PMID: 1557050).
noncanonical V-NONAMER: atagtaatt instead of acacaaacc, however this V-GENE has been found rearranged
DELETION of 1 nucleotide in the FR1-IMGT leading to a frameshift.
JUNCTION is out_of_ frame .

IMGT references: ↑

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IMGT Repertoire (IG and TR)

Dynamic gene tables per IMGT group and per species

Gene table legend:

Sequences assigned to mapped genes at 12F2 by sequence comparison

IMGT notes: ↑

IMGT references: ↑

IMGT Repertoire (IG and TR)

Dynamic gene tables per IMGT group and per species

Version 1.3

Version 1.2

Version 1.1

Version 1.0

Gene table legend:

Sequences assigned to mapped genes at 12F2 by sequence comparison

IMGT notes: ↑

IMGT references: ↑