IMGT Repertoire (IG and TR)

Fct: FUNCTIONALITY
- F: Functional
- P: Pseudogene
- ORF: Open Reading Frame
R: Rearranged
T: Transcribed
Pr: Translated into protein

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

Click on:

IMGT gene name to get the corresponding IMGT/GENE-DB entry,
IMGT allele name to see the corresponding Alignments of alleles,
accession number to get the corresponding IMGT/LIGM-DB entry.

The 3 House mouse (Mus musculus) IGLV subgroups belong to three clans (Figure IGLV clans). Clans comprise, respectively:

clan I: IGLV3 subgroup (IGLV4 to IGLV8 genes)
clan III: IGLV1 subgroup (IGLV1 and IGLV2 genes)
clan V: IGLV2 subgroup (IGLV3 gene)

Click here for Number of genes as deduced by RFLP analysis.

IMGT subgroup		IMGT gene name	IMGT allele name		Fct	Chromosomal localization	R	T	Pr	Positions in the locus	IMGT/LIGM-DB reference sequences									IMGT/LIGM-DB sequences from the literature
IMGT subgroup		IMGT gene name	IMGT allele name		Fct	Chromosomal localization	R	T	Pr	Positions in the locus	Strain	Clone names		Accession numbers	Positions in the sequence (V-REGION)				Secondary accession numbers	Strain	Clone names	Accession numbers		Positions in the sequence (V-REGION)
IGLV1		IGLV1		(1)
IGLV1		IGLV2	IGLV2*01		F						SPE	IGLV2SPE (Vlambda2SPE)	MAP		M17529	[1]	(2)				B6.lambdaSEG	Vlambda2SEG	MAP	AF357989	[2]
IGLV2		IGLV3	IGLV3*01		F						B6.lambdaSEG	VlambdaxSEG	MAP		AF357988	[2]
IGLV3	(3)	IGLV4	IGLV4*01		[F]						SMZ	SMZ1			AF357978	[2]	(4)	°
		IGLV4	IGLV4*02		[F]						STF	STF2			AF357975	[2]	(4)	°
		IGLV8	IGLV8*01		[F]						SMZ	SMZ2			AF357977	[2]	(4)	°			STF	STF1		AF357976	[2]	°

°: genomic DNA, but not known as being germline or rearranged.
MAP: Mapped reference sequences.

IMGT notes:

(1) The cluster IGLV1-IGLJ3-IGLC3-IGLJ1-IGLC1 is deleted in B6.lambdaSEG and probably also in the lost strain SPE [2].
(2) M17529 was assigned to the IGLV2 gene [2].
(3) Genes belonging to the IGLV3 subgroup may vary from 0 to 3 depending from the Mus spretus strains as deduced from RFLP analysis. Mus spretus IGLV3 subgroup gene names are by homology with Mus musculus genes [2].
(4) Partial V-REGION: partial FR1-IMGT (AA 1 to 4 are absent) and partial FR3-IMGT (AA 99 to 104 are absent).

IMGT references:

[1] Mami F. and Kindt, T.J., Immunogenetics, 26, 291-295 (1987). PMID:2820875
[2] Amrani Y.M. et al., Immunogenetics, 54, 106-119 (2002). PMID:12037603

See also (IMGT Scientific chart):

Created:: 03/11/1999
Last updated:: 22/09/2023
Authors:: Dominique Scaviner, Delphine Guiraudou

IMGT Repertoire (IG and TR)

Gene table: western wild mouse (Mus spretus) IGLV