IMGT Repertoire (IG and TR)


Locus representation: human (Homo sapiens) IGK locus on chromosome 2 assembly T2T_YAO_v2_mat

Citing this page: IMGT/LIGM-DB: IMGT000305 (1895392 bp), Human (Homo sapiens) IGK locus on chromosome 2.

Human (Homo sapiens) IGK locus on chromosome 2 assembly T2T_YAO_v2_mat

The orientation of the human (Homo sapiens) IGK locus on chromosome 2 assembly T2T_YAO_v2_mat is reverse (REV).

Locus representation human (<em>Homo sapiens</em>) IGK locus on chromosome 2 assembly T2T_YAO_v2_mat

Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.
A double slash // indicates a gap in genome assembly. Distances in bp (base pair) or in kb (kilobase) associated with a double slash are taken into account in the length of the lines and included in the numbers displayed at the right end of the lines.

The IGKV genes of the proximal V-CLUSTER are designated by a number for the subgroup, followed by a hyphen and a number for the localization from 3' to 5' in the locus.
The IGKV genes of the distal duplicated V-CLUSTER are designated by the same numbers as the corresponding genes in the proximal V-CLUSTER, with the letter D added.
Arrows show the IGKV genes whose orientation is opposite to that of the J-C-CLUSTER.

The Human (Homo sapiens) IGKV genes belong to seven subgroups (Gene table: Human IGKV) which are part of three clans (Figure IGKV clans). Clans comprise, respectively:

  • clan I: IGKV1 subgroup genes
  • clan II: IGKV2, IGKV3, IGKV4 and IGKV6 subgroup genes
  • clan III: IGKV5 and IGKV7 subgroup genes
IMGT references:
  1. [1] Zachau, H.G., Gene, 135, 167-173 (1993).
  2. [2] Zachau, H.G., The Immunologist, 4, 49-54 (1996).
  3. [3] Lefranc, M.-P. and Lefranc, G., The immunoglobulin FactsBook, Academic Press, London, 458 pages (2001). 012441351X
  4. [4] Lefranc, M.-P., Nomenclature of the human immunoglobulin genes, Current Protocols in Immunology, A.1P.1-A.1P.37 (2000).
IGKV genes
  1. [5] Hüber, C. et al., Eur. J. Immunol., 23, 2868-2875 (1993).
  2. [6] Schäble, K.F. and Zachau, H.G., Biol. Chem. Hoppe-Seyler, 374, 1001-1022 (1993).
  3. [7] Cox, J.P. et al., Eur. J. Immunol., 24, 827-836 (1994).
  4. [8] Schäble, K.F. et al., Biol. Chem. Hoppe-Seyler, 375, 189-199 (1994).
IGKJ genes
  1. [9] Hieter, P.A. et al., J. Biol. Chem., 257, 1516-1522 (1982).
IGKC gene
  1. [10] Hieter, P.A. et al., Cell, 22,197-207 (1980).
Enhancers
  1. [11] Emorine, L. et al., Nature, 304, 447-449 (1983) (IGKJ-IGKC intron).
  2. [12] Gimble, J.M. and Max, E.E., Mol. Cell. Biol., 7, 15-25 (1987).
  3. [13] Judde, J.G. and Max, E.E., Mol. Cell. Biol., 12, 5206-5216 (1992).
Orphon
  1. [14] Dunham, I. et al., Nature, 402, 489-495 (1999).
Assembly
  1. [15] He, Y. et al., Genomics, proteomics & bioinformatics, 21(6), 1085–1100 (2023).
  2. [16] Chu, Y. et al., bioRxiv (2025).
Created:
26/11/2025
Last updated:
26/11/2025
Authors:
Maria Georga, Ariadni Papadaki, Géraldine Folch, Ifigeneia Sideri, Joumana Jabado-Michaloud, Véronique Giudicelli and Sofia Kossida