IMGT Repertoire (IG and TR)


Locus representation: human (Homo sapiens) TRA locus on chromosome 14 (14q11.2)

Citing this page: Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, London, 398 pages (2001)

Human (Homo sapiens) TRA locus on chromosome 14 (14q11.2)

The orientation of the human (Homo sapiens) TRA locus on chromosome 14 (14q11.2) is forward (FWD).

Locus representation human (<em>Homo sapiens</em>) TRA locus on chromosome 14 (14q11.2)

Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.
A double slash // indicates a gap in genome assembly. Distances in bp (base pair) or in kb (kilobase) associated with a double slash are taken into account in the length of the lines and included in the numbers displayed at the right end of the lines.

A small arrow shows a gene (TRDV3) whose polarity is opposite to that of the TRD D-J-C-CLUSTER.

Bornes of the human (Homo sapiens) TRA/TRD locus

• No 5' borne conserved between species has been identified upstream of TRAV1-1 (F), the most 5' gene in the locus.
• DAD1 (defender against cell death) (3' borne) has been identified 13 kb downstream of TRAC (F), the most 3' gene in the locus.

Updates

• Update of the functionality for TRAV8-7 (P instead of ORF) (15/07/19).
• Addition of the 3' borne DAD1 (F), of the functionality P for TRAV35 and of 7 TRAV P, from 5' to 3': TRAVA, TRAVB, TRAV14-1, TRAV11-1, TRAVC, TRAV8-6-1 and TRAV46 (07/11/19).

Locus representation with only the functional genes: human (Homo sapiens) TRA locus on chromosome 14 (14q11.2)

Gene localization is according to data from IMGT/LocusView.
This locus representation with only the functional genes is used with IMGT/GeneFrequency.

Locus representation human (<em>Homo sapiens</em>) TRA locus on chromosome 14 (14q11.2)

* When needed, indicate the presence of allele(s) with another functionality: see above human (Homo sapiens) TRA locus on chromosome 14 (14q11.2)

Zoom for TRA/TRDJ genes

zoom

IMGT references:
  1. [1] Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, London, 398 pages (2001).
  2. [2] Lefranc, M.-P., Nomenclature of the human T cell receptor genes, Current Protocols in Immunology, A.1O.1-A.1O.23 (2000).
TRAV genes
  1. [3] Boysen, C. et al., unpublished (AE000658,AE000659,AE000660,AE000661).
TRAV alignments
  1. [4] Arden, B. et al., Immunogenetics, 42, 455-500 (1995).
TRAJ genes
  1. [5] Koop, B.F. et al., Genomics, 19, 478-493 (1994).
TRAC genes
  1. [6] Baer, R. et al., Mol. Biol. Med., 3, 265-277 (1986).
  2. [7] Yoshikai, Y. et al., Nature, 316, 837-840 (1985).
TRA enhancer (4,5 kb 3' from TRAC)
  1. [8] Ho, I.C. et al., Proc. Natl. Acad. Sci. USA, 86, 6714-6718 (1989).
TRDV genes
  1. [9] Boysen, C. et al., unpublished (AE000660,AE000661).
TRDD genes
  1. [10] Takihara, Y. et al., Proc. Natl. Acad. Sci. USA. 85, 6097-6101 (1988).
  2. [11] Loh, E.Y. et al., Proc. Natl. Acad. Sci. USA. 85, 9714-9718 (1988).
TRDJ genes
  1. [12] Isobe, M. et al., Proc. Natl. Acad. Sci. USA. 85, 3933-3937 (1988).
  2. [13] Loh, E.Y. et al., Proc. Natl. Acad. Sci. USA. 85, 9714-9718 (1988).
  3. [14] Satyanarayana, K. et al., Proc. Natl. Acad. Sci. USA. 85, 8166-8170 (1988).
TRDC genes
  1. [15] Takihara, Y. et al., Proc. Natl. Acad. Sci. USA. 85, 6097-6101 (1988).
TRD enhancer (between TRDJ3 and TRDC)
  1. [16] Redondo, J.M. et al., Science, 247, 1225-1229 (1990).
  2. [17] Bories, J.C. et al., J. Exp. Med. 171, 75-83 (1990).
Created:
11/07/2003
Last updated:
22/09/2023
Authors:
Viviane Nguefack Ngoune, Dominique Scaviner and Marie-Paule Lefranc