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Database contains
247103 sequences
from 361 species

IMGT/LIGM-DB sequence

Version:
1.2.9
Database release:
LIGMDB_V12
Citing IMGT/LIGM-DB:
Giudicelli, V., Duroux P., Ginestoux C., Folch G., Jabado-Michaloud J., Chaume D., Lefranc M.-P., Nucleic Acids Res., 34:D781-D784 (2006). PMID:16381979 Abstract Full PDF

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AY135487 - Annotation

Sections
Accession number AY135487
Sequence version 1
Secondary accession numbers
IMGT annotation level by annotators
Definition Ovis aries T cell receptor variable region Vgamma5.1 gene, partial cds.
Species Ovis aries (sheep)
Taxonomy Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis; Ovis aries
Sequence length 1477
IMGT/LIGM-DB dates 25-SEP-2002
  05-DEC-2019 (v. 6)

OBTENTION

Specificities
Disease related

IDENTIFICATION

Molecule type gDNA
Configuration type germline
Gene type variable
Molecule entity type V-gene
Functionality type functional
Chain type TR-Gamma-TRG
Structure type regular
Location type
Other keywords antigen receptor, Immunoglobulin superfamily (IgSF), T cell receptor (TR), IMGT reference sequence

CLASSIFICATION

IMGT Groups TRGV
IMGT Subgroups TRGV5

DESCRIPTION

V-GENE   1..1477
  db_xref taxon:9940
  functional
  germline
  IMGT_allele TRGV5-1*02
  IMGT_gene TRGV5-1
  mol_type genomic DNA
  organism Ovis aries
5'UTR   1..646
L-V-GENE-UNIT   647..1179
L-INTRON-L   647..855
L-PART1   647..686
atgcgggccccagcactgcttctggttgtcttggctcctg M R A P A L L L V V L A P
C G P Q H C F W L S W L L
A G P S T A S G C L G S
INIT-CODON   647..649
DONOR-SPLICE   686..688
V-INTRON   687..844
ACCEPTOR-SPLICE   842..846
V-EXON   845..1140
  db_xref REMTREMBL:AAN05729
  product T cell receptor variable region Vgamma5.1
  protein_id AAN05729.1
tcatgcaggtatcttccaacttgatgttaatcactagaaagactggggagactgcttcgttcccttgtgatcttacacacggggctatctatatccacttgtacaaacatgaggaggggatggccccccgacgccttttatactatgacagctacaactcaaagcctgtgtttgaatcaggaatcagtggaacaaaataccatgtctataagggcacagggagtagctatacatttacaatcgtaaatctgcaagcaagtgattccggcatatactactgtgctatctgggataag S C R Y L P T * C * S L E R L G R L L R S L V I L H T G L S I S T C T N M R R G W P P D A F Y T M T A T T Q S L C L N Q E S V E Q N T M S I R A Q G V A I H L Q S * I C K Q V I P A Y T T V L S G I
H A G I F Q L D V N H * K D W G D C F V P L * S Y T R G Y L Y P L V Q T * G G D G P P T P F I L * Q L Q L K A C V * I R N Q W N K I P C L * G H R E * L Y I Y N R K S A S K * F R H I L L C Y L G *
M Q V S S N L M L I T R K T G E T A S F P C D L T H G A I Y I H L Y K H E E G M A P R R L L Y Y D S Y N S K P V F E S G I S G T K Y H V Y K G T G S S Y T F T I V N L Q A S D S G I Y Y C A I W D K
L-PART2   845..855
tcatgcaggta S C R
H A G
M Q V
V-REGION   856..1140
  CDR_length [5.8.5]
  FR_length [22.17.38.G]
  functional
  IMGT_allele TRGV5-1*02
  IMGT_gene TRGV5-1
tcttccaacttgatgttaatcactagaaagactggggagactgcttcgttcccttgtgatcttacacacggggctatctatatccacttgtacaaacatgaggaggggatggccccccgacgccttttatactatgacagctacaactcaaagcctgtgtttgaatcaggaatcagtggaacaaaataccatgtctataagggcacagggagtagctatacatttacaatcgtaaatctgcaagcaagtgattccggcatatactactgtgctatctgggataag S S N L M L I T R K T G E T A S F P C D L T H G A I Y I H L Y K H E E G M A P R R L L Y Y D S Y N S K P V F E S G I S G T K Y H V Y K G T G S S Y T F T I V N L Q A S D S G I Y Y C A I W D K
L P T * C * S L E R L G R L L R S L V I L H T G L S I S T C T N M R R G W P P D A F Y T M T A T T Q S L C L N Q E S V E Q N T M S I R A Q G V A I H L Q S * I C K Q V I P A Y T T V L S G I
F Q L D V N H * K D W G D C F V P L * S Y T R G Y L Y P L V Q T * G G D G P P T P F I L * Q L Q L K A C V * I R N Q W N K I P C L * G H R E * L Y I Y N R K S A S K * F R H I L L C Y L G *
FR1-IMGT   856..921
  AA_IMGT AA 1 to 26, AA 5, 6, 7 and 8 are missing
tcttccaacttgatgttaatcactagaaagactggggagactgcttcgttcccttgtgatcttaca S S N L M L I T R K T G E T A S F P C D L T
L P T * C * S L E R L G R L L R S L V I L
F Q L D V N H * K D W G D C F V P L * S Y
1st-CYS   910..912
CDR1-IMGT   922..936
  AA_IMGT AA 27 to 38, AA 30, 31, 32, 33, 34, 35 and 36 are missing
cacggggctatctat H G A I Y
T G L S
R G Y L
FR2-IMGT   937..987
  AA_IMGT AA 39 to 55
  IMGT_note CONSERVED-TRP is replaced by LEU : ctg instead of tgg
atccacttgtacaaacatgaggaggggatggccccccgacgccttttatac I H L Y K H E E G M A P R R L L Y
S T C T N M R R G W P P D A F Y
P L V Q T * G G D G P P T P F I
CDR2-IMGT   988..1011
  AA_IMGT AA 56 to 65, AA 60 and 61 are missing
tatgacagctacaactcaaagcct Y D S Y N S K P
M T A T T Q S
* Q L Q L K A
FR3-IMGT   1012..1125
  AA_IMGT AA 66 to 104, AA 82 missing
gtgtttgaatcaggaatcagtggaacaaaataccatgtctataagggcacagggagtagctatacatttacaatcgtaaatctgcaagcaagtgattccggcatatactactgt V F E S G I S G T K Y H V Y K G T G S S Y T F T I V N L Q A S D S G I Y Y C
C L N Q E S V E Q N T M S I R A Q G V A I H L Q S * I C K Q V I P A Y T T
V * I R N Q W N K I P C L * G H R E * L Y I Y N R K S A S K * F R H I L L
2nd-CYS   1123..1125
CDR3-IMGT   1126..1140
  AA_IMGT AA 105 to 109
gctatctgggataag A I W D K
L S G I
Y L G *
3'UTR   1141..1477
V-RS   1141..1179
V-HEPTAMER   1141..1147
V-SPACER   1148..1170
V-NONAMER   1171..1179

Literature references

[1] 1-95092
Miccoli M.C., Lipsi M.R., Massari S., Lanave C., Ciccarese S.
Exon-intron organization of TRGC genes in sheep
Immunogenetics 53(5):416-422 (2001)
DOI: 10.1007/s002510100340
PUBMED: 11486279
[2] 1-95092
Miccoli M.C., Antonacci R., Vaccarelli G., Lanave C., Massari S., Cribiu E.P., Ciccarese S.
Evolution of TRG clusters in cattle and sheep genomes as drawn from the structural analysis of the ovine TRG2@ locus
J. Mol. Evol. 57(1):52-62 (2003)
DOI: 10.1007/s00239-002-2451-9
PUBMED: 12962306
[3] 1-95092
Vaccarelli G., Miccoli M.C., Lanave C., Massari S., Cribiu E.P., Ciccarese S.
Genomic organization of the sheep TRG1@ locus and comparative analyses of Bovidae and human variable genes
Gene 357(2):103-114 (2005)
DOI: 10.1016/j.gene.2005.05.033
PUBMED: 16125878
[4] 1-95092
Vaccarelli G., Miccoli M.C., Antonacci R., Pesole G., Ciccarese S.
Joining-constant blocks as markers of TRG loci evolution in Bovidae: putative role for enhancer-like sequences in driving coordinated recombinational unit duplications
Unpublished
[5] 1-95092
Miccoli M.C., Lipsi M.R., Massari S., Fiorentino F., Lanave C., Ciccarese S.
Submitted to the ENA/GenBank/DDBJ databases (03-MAR-2000)
Institute of Genetics, University of Bari, via Amendola 165/a, Bari, BA 70126, Italy
[6] 1-95092
Miccoli M.C., Lipsi M.R., Massari S., Fiorentino F., Lanave C., Ciccarese S.
Submitted to the ENA/GenBank/DDBJ databases (12-OCT-2000)
Institute of Genetics-DAPEG, University of Bari, via Amendola 165/a, Bari, Ba 70126, Italy
[7] 1-95092
Miccoli M.C., Vaccarelli G., Antonacci R., Lanave C., Lanave C., Massari S., Cribiu E.P., Ciccarese S.
Submitted to the ENA/GenBank/DDBJ databases (24-JUL-2002)
Dipartimento di Anatomia Patologica e di Genetica, University of Bari, via Amendola 165/a, Bari, Ba 70126, Italy
[8] 1-95092
Miccoli M.C., Vaccarelli G., Antonacci R., Lanave C., Massari S., Cribiu E.P., Ciccarese S.
Submitted to the ENA/GenBank/DDBJ databases (23-AUG-2002)
Dipartimento di Anatomia Patologica e di Genetica, University of Bari, via Amendola 165/a, Bari, Ba 70126, Italy
[9] 1-95092
Vaccarelli G., Miccoli M.C., Lanave C., Pagliarulo D., Cribiu E., Ciccarese S.
Submitted to the ENA/GenBank/DDBJ databases (25-JUL-2003)
Dipartimento di Anatomia Patologica e di Genetica, University of Bari, via Amendola 165/a, Bari, Ba 70126, Italy
[10] 1-95092
Antonacci R., Vaccarelli G., Cribiu P.E., Iannuzzi L., Ciccarese S.
Submitted to the ENA/GenBank/DDBJ databases (07-NOV-2005)
Dipartimento di Genetica e Microbiologia, University of Bari, via Amendola 165/a, Bari, Ba 70126, Italy
[11] 1-95092
Vaccarelli G., Miccoli M.C., Antonacci R., Pesole G., Ciccarese S.
Submitted to the ENA/GenBank/DDBJ databases (11-SEP-2006)
Dipartimento di Genetica e Microbiologia, University of Bari, via Amendola 165/a, Bari, Ba 70126, Italy

Database cross-references

Database Identifiers Relation
ENA AY135487
REMTREMBL AAN05729

Sequence

Length : 1477 BP
Composition : 372 A; 360 C; 353 G; 392 T; 0 other

     agccctttta ttggaggaat gaacattgag tcctctcccc aaactgattt taaaaacatg        60
     gcccaccccg gaacccacct tccttttagt tttaagggcc catccaaagg taagacataa       120
     atcaatccct aagttttctt aaataaaagc aaggttcagt tccttattgg ggttctccca       180
     gttggttgcc tccgagtttt gcttacaggg gaaaaaagga aaaggtagtt ccaggaaagg       240
     aatataaaag atgtctccgg gacaagaccg tggcagcagc atacacactg acatgctgga       300
     aactgcaggg aacttagccc gctcagggac tgctcactcc ataggcaaca ggcaagcttg       360
     gcccatggct ctcctcccat catttcgcat ttgatccatc tgcttgcagt tctgagttct       420
     cagtgctcaa gcccctcctc tcctgtgggg gagatagcag ctcccagcct gccacagggg       480
     ggccctcaag aaagggttgg tgcagagagg cggggctcct ccccaggcct ccgccagcac       540
     ccaccccctc tggaatcagc ctggtggtct ttaagagaga tcctccctga cttctctgcc       600
     tgtcacatct gctcagcatc ccagtctagc tgactgctgg ggcaggatgc gggccccagc       660
     actgcttctg gttgtcttgg ctcctggtaa gtgtgttgcc tgaatgctcc tggaattttt       720
     ctgtatgttg tggcaatgtg tgttgggggg gagcgggggg gaggggggac tgtggggaag       780
     agggtcagac taagaaatta gtgcttctct tcctcattat tttttgttgc cttttccatt       840
     gcagtcatgc aggtatcttc caacttgatg ttaatcacta gaaagactgg ggagactgct       900
     tcgttccctt gtgatcttac acacggggct atctatatcc acttgtacaa acatgaggag       960
     gggatggccc cccgacgcct tttatactat gacagctaca actcaaagcc tgtgtttgaa      1020
     tcaggaatca gtggaacaaa ataccatgtc tataagggca cagggagtag ctatacattt      1080
     acaatcgtaa atctgcaagc aagtgattcc ggcatatact actgtgctat ctgggataag      1140
     cacgttggtt cagacttcct gtacactgca ctggaaattt tgcttgtggc tgaaaatcac      1200
     agccctgata tcagcagcta cttcacttcc tcccccaatt tctttttact ctaaacaaag      1260
     aaaaccctga actcaatgcc catgaatcaa actttatatt ccatggtcac agtctatagg      1320
     caagcagtct ggcaggcagg atattcttag ctctccagaa gctggtagag ttcatatgat      1380
     tttctcttaa gacagacaga gacctaggat tatctgtgag gggatattta ggagaggtaa      1440
     atgggaaagg ctagataata ctgaaccatt cacctga                               1477
Created:
23/07/1995
Database development:
Denys CHAUME, Patrice DUROUX, Nelly JOUFFRE
Database scientific officer:
Marie-Paule Lefranc