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Database contains
247103 sequences
from 361 species

IMGT/LIGM-DB sequence

Version:
1.2.9
Database release:
LIGMDB_V12
Citing IMGT/LIGM-DB:
Giudicelli, V., Duroux P., Ginestoux C., Folch G., Jabado-Michaloud J., Chaume D., Lefranc M.-P., Nucleic Acids Res., 34:D781-D784 (2006). PMID:16381979 Abstract Full PDF

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J00242 - Annotation

Sections
Accession number J00242
Sequence version 1
Secondary accession numbers J00243; V00556
IMGT annotation level by annotators
Definition Homo sapiens immunoglobulin kappa chain variable region (IGKV) gene, J1-J5 region.
Species Homo sapiens (human)
Taxonomy cellular organisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens
Sequence length 1871
IMGT/LIGM-DB dates 15-MAY-1995
  11-OCT-2022 (v. 21)

OBTENTION

Specificities
Disease related

IDENTIFICATION

Molecule type gDNA
Configuration type germline
Gene type joining
Molecule entity type J-gene
Functionality type functional
Chain type IG-Light, IG-Light-Kappa-IGK
Structure type regular
Location type
Other keywords antigen receptor, Immunoglobulin superfamily (IgSF), immunoglobulin (IG), IMGT reference sequence

CLASSIFICATION

IMGT Groups
IMGT Subgroups

DESCRIPTION

J-CLUSTER   1..1871
  chromosome 2
  db_xref taxon:9606
  IMGT_map 2p11.2
  mol_type genomic DNA
  organism Homo sapiens
  tissue_type placenta
J-GENE   1..451
  functional
  IMGT_allele IGKJ1*01
  IMGT_gene IGKJ1
5'UTR   1..250
J-GENE-UNIT   212..288
  IMGT_allele IGKJ1*01
  IMGT_gene IGKJ1
J-RS   212..250
J-NONAMER   212..220
J-SPACER   221..243
J-HEPTAMER   244..250
J-REGION   251..288
  IMGT_allele IGKJ1*01
  IMGT_gene IGKJ1
gtggacgttcggccaagggaccaaggtggaaatcaaac V D V R P R D Q G G N Q
W T F G Q G T K V E I K
G R S A K G P R W K S N
5'J-REGION   251..260
gtggacgttc V D V
W T F
G R
J-MOTIF   258..269
ttcggccaaggg F G Q G
S A K
R P R
J-PHE   258..260
J-TRP   258..260
DONOR-SPLICE   288..290
3'UTR   289..451
J-GENE   452..784
  functional
  IMGT_allele IGKJ2*01
  IMGT_gene IGKJ2
5'UTR   452..611
J-GENE-UNIT   573..650
  IMGT_allele IGKJ2*01
  IMGT_gene IGKJ2
J-RS   573..611
J-NONAMER   573..581
J-SPACER   582..604
J-HEPTAMER   605..611
J-REGION   612..650
  IMGT_allele IGKJ2*01
  IMGT_gene IGKJ2
tgtacacttttggccaggggaccaagctggagatcaaac C T L L A R G P S W R S N
V H F W P G D Q A G D Q
Y T F G Q G T K L E I K
5'J-REGION   612..622
tgtacactttt C T L
V H F
Y T F
J-MOTIF   620..631
tttggccagggg F G Q G
L A R
W P G
J-PHE   620..622
J-TRP   620..622
DONOR-SPLICE   650..652
3'UTR   651..784
J-GENE   785..1108
  functional
  IMGT_allele IGKJ3*01
  IMGT_gene IGKJ3
5'UTR   785..917
J-GENE-UNIT   880..955
  IMGT_allele IGKJ3*01
  IMGT_gene IGKJ3
J-RS   880..917
J-NONAMER   880..888
J-SPACER   889..910
J-HEPTAMER   911..917
J-REGION   918..955
  IMGT_allele IGKJ3*01
  IMGT_gene IGKJ3
attcactttcggccctgggaccaaagtggatatcaaac I H F R P W D Q S G Y Q
F T F G P G T K V D I K
S L S A L G P K W I S N
5'J-REGION   918..927
attcactttc I H F
F T F
S L
J-MOTIF   925..936
ttcggccctggg F G P G
S A L
R P W
J-PHE   925..927
J-TRP   925..927
DONOR-SPLICE   955..957
3'UTR   956..1108
J-GENE   1109..1436
  functional
  IMGT_allele IGKJ4*01
  IMGT_gene IGKJ4
5'UTR   1109..1259
J-GENE-UNIT   1221..1297
  IMGT_allele IGKJ4*01
  IMGT_gene IGKJ4
J-RS   1221..1259
J-NONAMER   1221..1229
J-SPACER   1230..1252
J-HEPTAMER   1253..1259
J-REGION   1260..1297
  IMGT_allele IGKJ4*01
  IMGT_gene IGKJ4
gctcactttcggcggagggaccaaggtggagatcaaac A H F R R R D Q G G D Q
L T F G G G T K V E I K
S L S A E G P R W R S N
5'J-REGION   1260..1269
gctcactttc A H F
L T F
S L
J-MOTIF   1267..1278
ttcggcggaggg F G G G
S A E
R R R
J-PHE   1267..1269
J-TRP   1267..1269
DONOR-SPLICE   1297..1299
3'UTR   1298..1436
J-GENE   1437..1871
  functional
  IMGT_allele IGKJ5*01
  IMGT_gene IGKJ5
5'UTR   1437..1574
J-GENE-UNIT   1536..1612
  IMGT_allele IGKJ5*01
  IMGT_gene IGKJ5
J-RS   1536..1574
J-NONAMER   1536..1544
J-SPACER   1545..1567
J-HEPTAMER   1568..1574
J-REGION   1575..1612
  IMGT_allele IGKJ5*01
  IMGT_gene IGKJ5
gatcaccttcggccaagggacacgactggagattaaac D H L R P R D T T G D *
I T F G Q G T R L E I K
S P S A K G H D W R L N
5'J-REGION   1575..1584
gatcaccttc D H L
I T F
S P
J-MOTIF   1582..1593
ttcggccaaggg F G Q G
S A K
R P R
J-PHE   1582..1584
J-TRP   1582..1584
DONOR-SPLICE   1612..1614
3'UTR   1613..1871
J-C-INTRON   1613..1871

Literature references

[1] 1229-1329
Hieter P.A., Max E.E., Seidman J.G., Maizel J.V.Jr., Leder P.
Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments
Cell 22(1 Pt 1):197-207 (1980)
DOI: 10.1016/0092-8674(80)90168-3
PUBMED: 6775818
[2] 1-1871
Hieter P.A., Maizel J.V.Jr., Leder P.
Evolution of human immunoglobulin kappa J region genes
J. Biol. Chem. 257(3):1516-1522 (1982)
PUBMED: 6276389

Database cross-references

Database Identifiers Relation
EMBL-ALIGN ALIGN_000322
ENA J00242
GDB 119341
GDB 9953169
GDB 9953424
GDB 9953426
GDB 9953428
GDB 9953430

Sequence

Length : 1871 BP
Composition : 574 A; 315 C; 446 G; 536 T; 0 other

     ataaatcaat aagcagtcca gatgtggcaa gttgtaagaa ggaaccatca aggccataga        60
     cgtaaatata ttctcttctt ggattttagg tctcacctaa agaaaataaa cacatgctat       120
     gtcagagaag cctcagggtt tccacacctg ctcgaaaagg gagttgagct tcagcagctg       180
     acccaggact ctgttcccct ttggtgagaa gggtttctgt tcagcaagac aatggagagc       240
     tctcactgtg gtggacgttc ggccaaggga ccaaggtgga aatcaaacgt gagtagaatt       300
     taaactttgc ttcctcagtt gtctgtgtct tctgttccct gtgtctatga agttgatcta       360
     taaggtgact ctgcaatcag cctctgacat ccttcaggga aaagataaag ataagtctgt       420
     agtcaaactc gagaattgat tgcacatttt ctttgaagag caagcaagat tcagtcattg       480
     ggtgagaata acttgtctaa gtaatagctt cagaaatgtc ctagggaaca taacatgttc       540
     tggacagagc cttggtcaat tgtcagaaag ggagtttttg tataggaggg aagttaagag       600
     gaaccattgt gtgtacactt ttggccaggg gaccaagctg gagatcaaac gtaagtactt       660
     ttttccactg attcttcact gttgctaatt agtttacttt gtgttccttt gtgtggattt       720
     tcattagtcg gatgccaggg actctaacaa acttcattcc caggttaggt acagaggagg       780
     ggaaattgtt ccacaggacg ctagcttgtg gctaattttt aagatttcta aatcaaaata       840
     acttcattgg gggaaagagg cttgctgagc tttcagggag gtttttgtaa agggaaaagt       900
     taagacgaat cactgtgatt cactttcggc cctgggacca aagtggatat caaacgtaag       960
     tacatctgtc tcaattattc gtgagatttt agtgccattg tatcatttgt gcaagttttg      1020
     tgcatatttt ggttgaataa acctggtcac ccagaagtaa atagcaggac accagaaaaa      1080
     tcgaaactta aaaaagctga gcaagtagaa cgacttcttt gggtttgaga ggagaataga      1140
     ttccttgggg gaaatgggga agaaatagct agatttttct ctgaacaagc agcctatctc      1200
     atatgattgg cttcaagaga ggtttttgtt gaggggaaag ggtgagatcc ctcactgtgg      1260
     ctcactttcg gcggagggac caaggtggag atcaaacgta agtgcacttt cctaatgctt      1320
     tttcttataa gtttaaattt gagcgttttt gtgtttgaga tattagctca ggtcaattcc      1380
     aaagagtacc agattctttc aaaaagtcag atgagtaagg gacagaaaat tagttcatct      1440
     taaggaacag ccaagcgcta gccagttaag tgaggcatct caattgcaag attttctctg      1500
     catcggtcag gctagtgata ttaacagcga aaagagattt ttgttaaggg gaaagtaatt      1560
     aagttaacac tgtggatcac cttcggccaa gggacacgac tggagattaa acgtaagcat      1620
     ttttcaccat tgtccgaaat ttcggtccga tggccagtat tgacctttag aggctcaaat      1680
     aggagtttgg taaagattgg taaatgaggg catttaagat ttgccatggg ttgcaaaagt      1740
     taaactcagc ttcaaaaatg gatttggaga aaaaaagatt aaattgctct gaaactgaat      1800
     gacacaaagt aaaaaaaaag tgcactaaaa aggaaccctt gcatttcgga aggaccaaga      1860
     gtaaatttat t                                                           1871
Created:
23/07/1995
Database development:
Denys CHAUME, Patrice DUROUX, Nelly JOUFFRE
Database scientific officer:
Marie-Paule Lefranc