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Database contains
247103 sequences
from 361 species

IMGT/LIGM-DB sequence

Version:
1.2.9
Database release:
LIGMDB_V12
Citing IMGT/LIGM-DB:
Giudicelli, V., Duroux P., Ginestoux C., Folch G., Jabado-Michaloud J., Chaume D., Lefranc M.-P., Nucleic Acids Res., 34:D781-D784 (2006). PMID:16381979 Abstract Full PDF

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L40735 - Annotation

Sections
Accession number L40735
Sequence version 1
Secondary accession numbers
IMGT annotation level by annotators
Definition Homo sapiens (clone LBPBL5) immunoglobulin kappa light chain mRNA, partial cds.
Species Homo sapiens (human)
Taxonomy cellular organisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens
Sequence length 300
IMGT/LIGM-DB dates 30-MAY-1996
  17-JAN-2013 (v. 9)

OBTENTION

Specificities
Disease related

IDENTIFICATION

Molecule type cDNA
Configuration type rearranged
Gene type variable, joining
Molecule entity type
Functionality type
Chain type IG-Light, IG-Light-Kappa-IGK
Structure type regular
Location type
Other keywords antigen receptor, Immunoglobulin superfamily (IgSF), immunoglobulin (IG), normal rearranged repertoire

CLASSIFICATION

IMGT Groups IGKV
IMGT Subgroups

DESCRIPTION

V-J-REGION   1..300
  cell_type B-lymphocyte
  clone LBPBL5
  db_xref PID:g722560
  dev_stage adult
  organism Homo sapiens
  product immunoglobulin kappa chain
  tissue_type blood
gccaccctgtctgtgtctccaggggaaagagccaccctctcctgcagggccagtcagagtgttagcagctacttagcctggtaccaacagaaacctggccaggctcccaggctcctcatctatgatgcatccaacagggccactggcatcccagccaggttcagtggcagtgggtctgggacagacttcactctcaccatcagcagactggagcctgaagattttgcagtgtattactgtcagcagtatggtagctcaccgatgtgcagttttggccaggggaccaagctggagatcaaa A T L S V S P G E R A T L S C R A S Q S V S S Y L A W Y Q Q K P G Q A P R L L I Y D A S N R A T G I P A R F S G S G S G T D F T L T I S R L E P E D F A V Y Y C Q Q Y G S S P M C S F G Q G T K L E I K
P P C L C L Q G K E P P S P A G P V R V L A A T * P G T N R N L A R L P G S S S M M H P T G P L A S Q P G S V A V G L G Q T S L S P S A D W S L K I L Q C I T V S S M V A H R C A V L A R G P S W R S
H P V C V S R G K S H P L L Q G Q S E C * Q L L S L V P T E T W P G S Q A P H L * C I Q Q G H W H P S Q V Q W Q W V W D R L H S H H Q Q T G A * R F C S V L L S A V W * L T D V Q F W P G D Q A G D Q
V-REGION   1..264
gccaccctgtctgtgtctccaggggaaagagccaccctctcctgcagggccagtcagagtgttagcagctacttagcctggtaccaacagaaacctggccaggctcccaggctcctcatctatgatgcatccaacagggccactggcatcccagccaggttcagtggcagtgggtctgggacagacttcactctcaccatcagcagactggagcctgaagattttgcagtgtattactgtcagcagtatggtagctcaccgatg A T L S V S P G E R A T L S C R A S Q S V S S Y L A W Y Q Q K P G Q A P R L L I Y D A S N R A T G I P A R F S G S G S G T D F T L T I S R L E P E D F A V Y Y C Q Q Y G S S P M
P P C L C L Q G K E P P S P A G P V R V L A A T * P G T N R N L A R L P G S S S M M H P T G P L A S Q P G S V A V G L G Q T S L S P S A D W S L K I L Q C I T V S S M V A H R
H P V C V S R G K S H P L L Q G Q S E C * Q L L S L V P T E T W P G S Q A P H L * C I Q Q G H W H P S Q V Q W Q W V W D R L H S H H Q Q T G A * R F C S V L L S A V W * L T D
FR1   1..45
  AA_number AA 9 to 23
gccaccctgtctgtgtctccaggggaaagagccaccctctcctgc A T L S V S P G E R A T L S C
P P C L C L Q G K E P P S P
H P V C V S R G K S H P L L
1st-CYS   43..45
CDR1   46..78
  AA_number AA 24 to 34
agggccagtcagagtgttagcagctacttagcc R A S Q S V S S Y L A
G P V R V L A A T *
G Q S E C * Q L L S
FR2   79..123
  AA_number AA 35 to 49
tggtaccaacagaaacctggccaggctcccaggctcctcatctat W Y Q Q K P G Q A P R L L I Y
G T N R N L A R L P G S S S
V P T E T W P G S Q A P H L
CONSERVED-TRP   79..81
CDR2   124..144
  AA_number AA 50 to 56
gatgcatccaacagggccact D A S N R A T
M H P T G P
C I Q Q G H
FR3   145..240
  AA_number AA 57 to 88
ggcatcccagccaggttcagtggcagtgggtctgggacagacttcactctcaccatcagcagactggagcctgaagattttgcagtgtattactgt G I P A R F S G S G S G T D F T L T I S R L E P E D F A V Y Y C
A S Q P G S V A V G L G Q T S L S P S A D W S L K I L Q C I T
H P S Q V Q W Q W V W D R L H S H H Q Q T G A * R F C S V L L
2nd-CYS   238..240
CDR3   241..270
  AA_number AA 89 to 97, including 95 A
cagcagtatggtagctcaccgatgtgcagt Q Q Y G S S P M C S
S S M V A H R C A
A V W * L T D V Q
JUNCTION   238..273
tgtcagcagtatggtagctcaccgatgtgcagtttt C Q Q Y G S S P M C S F
V S S M V A H R C A V
S A V W * L T D V Q F
J-REGION   265..300
  IMGT_allele IGKJ2*04
  IMGT_gene IGKJ2
tgcagttttggccaggggaccaagctggagatcaaa C S F G Q G T K L E I K
A V L A R G P S W R S
Q F W P G D Q A G D Q
J-PHE   271..273

Literature references

[1] 1-300
Bridges S.L.Jr., Lee S.K., Johnson M.L., Lavelle J.C., Fowler P.G., Koopman W.J., Schroeder H.W.Jr.
Somatic mutation and CDR3 lengths of immunoglobulin kappa light chains expressed in patients with rheumatoid arthritis and in normal individuals
J. Clin. Invest. 96(2):831-841 (1995)
PUBMED: 7635977

Database cross-references

Database Identifiers Relation
ENA L40735

Sequence

Length : 300 BP
Composition : 69 A; 86 C; 81 G; 64 T; 0 other

     gccaccctgt ctgtgtctcc aggggaaaga gccaccctct cctgcagggc cagtcagagt        60
     gttagcagct acttagcctg gtaccaacag aaacctggcc aggctcccag gctcctcatc       120
     tatgatgcat ccaacagggc cactggcatc ccagccaggt tcagtggcag tgggtctggg       180
     acagacttca ctctcaccat cagcagactg gagcctgaag attttgcagt gtattactgt       240
     cagcagtatg gtagctcacc gatgtgcagt tttggccagg ggaccaagct ggagatcaaa       300
Created:
23/07/1995
Database development:
Denys CHAUME, Patrice DUROUX, Nelly JOUFFRE
Database scientific officer:
Marie-Paule Lefranc