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Database contains
247103 sequences
from 361 species

IMGT/LIGM-DB sequence

Version:
1.2.9
Database release:
LIGMDB_V12
Citing IMGT/LIGM-DB:
Giudicelli, V., Duroux P., Ginestoux C., Folch G., Jabado-Michaloud J., Chaume D., Lefranc M.-P., Nucleic Acids Res., 34:D781-D784 (2006). PMID:16381979 Abstract Full PDF

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U95246 - Annotation

Sections
Accession number U95246
Sequence version 1
Secondary accession numbers
IMGT annotation level by annotators
Definition Human clone MC90 immunoglobulin rearranged light chain mRNA, partial cds.
Species Homo sapiens (human)
Taxonomy cellular organisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens
Sequence length 321
IMGT/LIGM-DB dates 27-MAY-1997
  18-JAN-2013 (v. 10)

OBTENTION

Specificities
Disease related

IDENTIFICATION

Molecule type cDNA
Configuration type undefined, rearranged
Gene type constant, variable, joining
Molecule entity type
Functionality type productive
Chain type IG-Light, IG-Light-Kappa-IGK
Structure type regular
Location type
Other keywords antigen receptor, Immunoglobulin superfamily (IgSF), immunoglobulin (IG), IMGT reference sequence

CLASSIFICATION

IMGT Groups IGKV
IMGT Subgroups IGKV1

DESCRIPTION

V-J-C-REGION   1..>321
  cell_type Epstein-Barr virus transformed B cell
  chromosome 2
  clone MC90
  db_xref PID:g2072280
  IMGT_map 2p11.2
  organism Homo sapiens
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcaccatcacttgccaggcgagtcaggacattagcaactatttaaattggtatcagcagaaaccaggaaaagcccctaaggtcctgatctacgatgcatccaatttgaaaacaggggtcccatcaaggttcaatggaagtggatctgggacagattttactttcaccatcagcagcctgcagcctgaagatattgcaacatattactgtcaacagtatgataatctgtacagttttggccaggggaccaagctggagatcaaacga D I Q M T Q S P S S L S A S V G D R V T I T C Q A S Q D I S N Y L N W Y Q Q K P G K A P K V L I Y D A S N L K T G V P S R F N G S G S G T D F T F T I S S L Q P E D I A T Y Y C Q Q Y D N L Y S F G Q G T K L E I K R
T S R * P S L H P P C L H L * E T E S P S L A R R V R T L A T I * I G I S R N Q E K P L R S * S T M H P I * K Q G S H Q G S M E V D L G Q I L L S P S A A C S L K I L Q H I T V N S M I I C T V L A R G P S W R S N
H P D D P V S I L P V C I C R R Q S H H H L P G E S G H * Q L F K L V S A E T R K S P * G P D L R C I Q F E N R G P I K V Q W K W I W D R F Y F H H Q Q P A A * R Y C N I L L S T V * * S V Q F W P G D Q A G D Q T
V-J-REGION   1..318
  CDR_length [6.3.8]
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcaccatcacttgccaggcgagtcaggacattagcaactatttaaattggtatcagcagaaaccaggaaaagcccctaaggtcctgatctacgatgcatccaatttgaaaacaggggtcccatcaaggttcaatggaagtggatctgggacagattttactttcaccatcagcagcctgcagcctgaagatattgcaacatattactgtcaacagtatgataatctgtacagttttggccaggggaccaagctggagatcaaa D I Q M T Q S P S S L S A S V G D R V T I T C Q A S Q D I S N Y L N W Y Q Q K P G K A P K V L I Y D A S N L K T G V P S R F N G S G S G T D F T F T I S S L Q P E D I A T Y Y C Q Q Y D N L Y S F G Q G T K L E I K
T S R * P S L H P P C L H L * E T E S P S L A R R V R T L A T I * I G I S R N Q E K P L R S * S T M H P I * K Q G S H Q G S M E V D L G Q I L L S P S A A C S L K I L Q H I T V N S M I I C T V L A R G P S W R S
H P D D P V S I L P V C I C R R Q S H H H L P G E S G H * Q L F K L V S A E T R K S P * G P D L R C I Q F E N R G P I K V Q W K W I W D R F Y F H H Q Q P A A * R Y C N I L L S T V * * S V Q F W P G D Q A G D Q
V-REGION   1..280
  IMGT_allele IGKV1-33*01
  IMGT_gene IGKV1-33
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcaccatcacttgccaggcgagtcaggacattagcaactatttaaattggtatcagcagaaaccaggaaaagcccctaaggtcctgatctacgatgcatccaatttgaaaacaggggtcccatcaaggttcaatggaagtggatctgggacagattttactttcaccatcagcagcctgcagcctgaagatattgcaacatattactgtcaacagtatgataatc D I Q M T Q S P S S L S A S V G D R V T I T C Q A S Q D I S N Y L N W Y Q Q K P G K A P K V L I Y D A S N L K T G V P S R F N G S G S G T D F T F T I S S L Q P E D I A T Y Y C Q Q Y D N
T S R * P S L H P P C L H L * E T E S P S L A R R V R T L A T I * I G I S R N Q E K P L R S * S T M H P I * K Q G S H Q G S M E V D L G Q I L L S P S A A C S L K I L Q H I T V N S M I I
H P D D P V S I L P V C I C R R Q S H H H L P G E S G H * Q L F K L V S A E T R K S P * G P D L R C I Q F E N R G P I K V Q W K W I W D R F Y F H H Q Q P A A * R Y C N I L L S T V * *
FR1-IMGT   1..78
  AA_IMGT 1 to 26
gacatccagatgacccagtctccatcctccctgtctgcatctgtaggagacagagtcaccatcacttgccaggcgagt D I Q M T Q S P S S L S A S V G D R V T I T C Q A S
T S R * P S L H P P C L H L * E T E S P S L A R R
H P D D P V S I L P V C I C R R Q S H H H L P G E
1st-CYS   67..69
CDR1-IMGT   79..96
  AA_IMGT AA 27 to 38, AA 30, 31, 32, 33, 34 and 35 are missing
caggacattagcaactat Q D I S N Y
R T L A T
G H * Q L
FR2-IMGT   97..147
  AA_IMGT 39 to 55
ttaaattggtatcagcagaaaccaggaaaagcccctaaggtcctgatctac L N W Y Q Q K P G K A P K V L I Y
* I G I S R N Q E K P L R S * S
K L V S A E T R K S P * G P D L
CONSERVED-TRP   103..105
CDR2-IMGT   148..156
  AA_IMGT AA 56 to 65, AA 58, 59, 60, 61, 62, 63 and 64 are missing
gatgcatcc D A S
M H
C I
FR3-IMGT   157..264
  AA_IMGT 66 to 104, AA 73,81,82 missing
aatttgaaaacaggggtcccatcaaggttcaatggaagtggatctgggacagattttactttcaccatcagcagcctgcagcctgaagatattgcaacatattactgt N L K T G V P S R F N G S G S G T D F T F T I S S L Q P E D I A T Y Y C
I * K Q G S H Q G S M E V D L G Q I L L S P S A A C S L K I L Q H I T
F E N R G P I K V Q W K W I W D R F Y F H H Q Q P A A * R Y C N I L L
2nd-CYS   262..264
CDR3-IMGT   265..288
  AA_IMGT AA 105 to 117, AA 109, 110, 111, 112 and 113 are missing
caacagtatgataatctgtacagt Q Q Y D N L Y S
N S M I I C T
T V * * S V Q
JUNCTION   262..291
tgtcaacagtatgataatctgtacagtttt C Q Q Y D N L Y S F
V N S M I I C T V
S T V * * S V Q F
J-REGION   281..318
  IMGT_allele IGKJ2*03
  IMGT_gene IGKJ2
tgtacagttttggccaggggaccaagctggagatcaaa C T V L A R G P S W R S
V Q F W P G D Q A G D Q
Y S F G Q G T K L E I K
J-PHE   289..291
C-REGION   319..>321

Literature references

[1] 1-321
Manheimer-Lory A.J.
Lupus-specific antibodies reveal an altered pattern of somatic mutation
Unpublished
[2] 1-321
Manheimer-Lory A.J.
Submitted to the ENA/GenBank/DDBJ databases (25-MAR-1997)
Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA

Database cross-references

Database Identifiers Relation
ENA U95246

Sequence

Length : 321 BP
Composition : 97 A; 78 C; 71 G; 75 T; 0 other

     gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc        60
     atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca       120
     ggaaaagccc ctaaggtcct gatctacgat gcatccaatt tgaaaacagg ggtcccatca       180
     aggttcaatg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct       240
     gaagatattg caacatatta ctgtcaacag tatgataatc tgtacagttt tggccagggg       300
     accaagctgg agatcaaacg a                                                 321
Created:
23/07/1995
Database development:
Denys CHAUME, Patrice DUROUX, Nelly JOUFFRE
Database scientific officer:
Marie-Paule Lefranc