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Database contains
247103 sequences
from 361 species

IMGT/LIGM-DB sequence

Version:
1.2.9
Database release:
LIGMDB_V12
Citing IMGT/LIGM-DB:
Giudicelli, V., Duroux P., Ginestoux C., Folch G., Jabado-Michaloud J., Chaume D., Lefranc M.-P., Nucleic Acids Res., 34:D781-D784 (2006). PMID:16381979 Abstract Full PDF

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X67858 - Annotation

Sections
Accession number X67858
Sequence version 1
Secondary accession numbers
IMGT annotation level by annotators
Definition H.sapiens DNA for IG kappa JC region
Species Homo sapiens (human)
Taxonomy cellular organisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens
Sequence length 5364
IMGT/LIGM-DB dates 21-MAY-1996
  31-MAY-2017 (v. 13)

OBTENTION

Specificities
Disease related

IDENTIFICATION

Molecule type gDNA
Configuration type germline, undefined
Gene type constant, joining
Molecule entity type J-gene, C-gene
Functionality type functional
Chain type IG-Light, IG-Light-Kappa-IGK
Structure type regular
Location type
Other keywords antigen receptor, Immunoglobulin superfamily (IgSF), immunoglobulin (IG), enhancer

CLASSIFICATION

IMGT Groups
IMGT Subgroups

DESCRIPTION

J-C-CLUSTER   1..5364
  db_xref taxon:9606
  mol_type genomic DNA
  organism Homo sapiens
J-CLUSTER   1..2660
J-GENE   1..450
  IMGT_allele IGKJ1*01
  IMGT_gene IGKJ1
5'UTR   1..250
J-NONAMER   212..220
J-SPACER   221..243
J-HEPTAMER   244..250
J-REGION   251..288
  IMGT_allele IGKJ1*01
  IMGT_gene IGKJ1
gtggacgttcggccaagggaccaaggtggaaatcaaac V D V R P R D Q G G N Q
W T F G Q G T K V E I K
G R S A K G P R W K S N
J-PHE   258..260
DONOR-SPLICE   288..290
3'UTR   289..450
J-GENE   451..802
  IMGT_allele IGKJ2*01
  IMGT_gene IGKJ2
5'UTR   451..610
J-NONAMER   572..580
J-SPACER   581..603
J-HEPTAMER   604..610
J-REGION   611..649
  IMGT_allele IGKJ2*01
  IMGT_gene IGKJ2
tgtacacttttggccaggggaccaagctggagatcaaac C T L L A R G P S W R S N
V H F W P G D Q A G D Q
Y T F G Q G T K L E I K
J-PHE   619..621
DONOR-SPLICE   649..651
3'UTR   650..802
J-GENE   803..1122
  IMGT_allele IGKJ3*01
  IMGT_gene IGKJ3
5'UTR   803..915
J-NONAMER   878..886
J-SPACER   887..908
J-HEPTAMER   909..915
J-REGION   916..953
  IMGT_allele IGKJ3*01
  IMGT_gene IGKJ3
attcactttcggccctgggaccaaagtggatatcaaac I H F R P W D Q S G Y Q
F T F G P G T K V D I K
S L S A L G P K W I S N
J-PHE   923..925
DONOR-SPLICE   953..955
3'UTR   954..1122
J-GENE   1123..1448
  IMGT_allele IGKJ4*01
  IMGT_gene IGKJ4
5'UTR   1123..1250
J-NONAMER   1212..1220
J-SPACER   1221..1243
J-HEPTAMER   1244..1250
J-REGION   1251..1288
  IMGT_allele IGKJ4*01
  IMGT_gene IGKJ4
gctcactttcggcggagggaccaaggtggagatcaaac A H F R R R D Q G G D Q
L T F G G G T K V E I K
S L S A E G P R W R S N
J-PHE   1258..1260
DONOR-SPLICE   1288..1290
3'UTR   1289..1448
J-GENE   1449..2660
  IMGT_allele IGKJ5*01
  IMGT_gene IGKJ5
5'UTR   1449..1568
J-NONAMER   1530..1538
J-SPACER   1539..1561
J-HEPTAMER   1562..1568
J-REGION   1569..1606
  IMGT_allele IGKJ5*01
  IMGT_gene IGKJ5
gatcaccttcggccaagggacacgactggagattaaac D H L R P R D T T G D *
I T F G Q G T R L E I K
S P S A K G H D W R L N
J-PHE   1576..1578
DONOR-SPLICE   1606..1608
J-C-INTRON   1607..5364
MISC_FEATURE   2661..3661
  note matrix association region (MAR)
C-GENE   3662..5364
  IMGT_allele IGKC*01
  IMGT_gene IGKC
ENHANCER   3742..3866
ACCEPTOR-SPLICE   4486..4490
CL   4489..4808
  IMGT_allele IGKC*01
  IMGT_gene IGKC
gaactgtggctgcaccatctgtcttcatcttcccgccatctgatgagcagttgaaatctggaactgcctctgttgtgtgcctgctgaataacttctatcccagagaggccaaagtacagtggaaggtggataacgccctccaatcgggtaactcccaggagagtgtcacagagcaggacagcaaggacagcacctacagcctcagcagcaccctgacgctgagcaaagcagactacgagaaacacaaagtctacgcctgcgaagtcacccatcagggcctgagctcgcccgtcacaaagagcttcaacaggggagagtgt E L W L H H L S S S S R H L M S S * N L E L P L L C A C * I T S I P E R P K Y S G R W I T P S N R V T P R R V S Q S R T A R T A P T A S A A P * R * A K Q T T R N T K S T P A K S P I R A * A R P S Q R A S T G E S
N C G C T I C L H L P A I * * A V E I W N C L C C V P A E * L L S Q R G Q S T V E G G * R P P I G * L P G E C H R A G Q Q G Q H L Q P Q Q H P D A E Q S R L R E T Q S L R L R S H P S G P E L A R H K E L Q Q G R V
T V A A P S V F I F P P S D E Q L K S G T A S V V C L L N N F Y P R E A K V Q W K V D N A L Q S G N S Q E S V T E Q D S K D S T Y S L S S T L T L S K A D Y E K H K V Y A C E V T H Q G L S S P V T K S F N R G E C
STOP-CODON   4809..4811
3'UTR   4809..5364

Literature references

[1] 1-5364
Garrard W.T.
Submitted to the ENA/GenBank/DDBJ databases (23-JUL-1992)
W.T. Garrard, UT Southwestern Medical Centre, Department of Biochemistry, 5323 Harry Hines Blvd., Dallas TX 75235, USA
[2] 1-5364
Whitehurst C., Henney H.R., Max E.E., Schroeder H.W., Stuber F., Siminovitch K., Garrard W.T.
Nucleotide sequence of the intron of the germline human kappa immunoglobulin gene connecting the J and C regions reveals a matrix association region (MAR) next to the enhancer
Nucleic Acids Res. 20(18):4929-4930 (1992)
DOI: 10.1093/nar/20.18.4929
PUBMED: 1408808

Database cross-references

Database Identifiers Relation
ENA X67858
TRANSFAC R01635, HS$IGKL_03
TRANSFAC R01636, HS$IGKL_04

Sequence

Length : 5364 BP
Composition : 1623 A; 1035 C; 1114 G; 1592 T; 0 other

     ataaataata agcagtccag atgtggcaag ttgcaaagaa aggaaccatc aggccataga        60
     cgtaaatata ttctcttctt ggattttagg tctcacctaa agaaaataaa cacatgctat       120
     gtcagagaag cctcagggtt tccacacctg ctcgaaaagg gagttgagct tcagcagctg       180
     acccaggact ctgttcccct ttggtgagaa gggtttctgt tcagcaagac aatggagagc       240
     tctcactgtg gtggacgttc ggccaaggga ccaaggtgga aatcaaacgt gagtagaatt       300
     taaactttgc ttcctcagtt gtctgtgtct tctgttccct gtgtctatga agtgatctat       360
     aaggtgactc tgcaatcagc ctctgatatc cttcagggaa aagataaaga taagtctgta       420
     gtcaaactcg agaattgatt gcacattttc tttgaagagc aagcaagatt cagtcattgg       480
     gtgagaataa cttgtctaag taatagcttc agaaatgtcc tggggaacat aacatgttct       540
     ggacagagcc ttggtcaatt gtcagaaagg gagtttttgt ataggaggga agttaagagg       600
     aaccattgtg tgtacacttt tggccagggg accaagctgg agatcaaacg taagtacttt       660
     tttccactga ttcttcactg ttgctaatta gtttactttg tgttcctttg tgtggatttt       720
     cattagtcgg atgccaggga tctaacaaac ttcattccca ggttaggtac agaggagggg       780
     aaattgttcc acaggacgct agcttgtggc taatttttaa gatttctaaa tcaaaataac       840
     ttcattgggg gaaagaggct tgctgagctt tcagggaggt ttttgtaaag ggaaaagtta       900
     agacgaatca ctgtgattca ctttcggccc tgggaccaaa gtggatatca aacgtaagta       960
     catctgtctc aattattcgt gagattttag tgccattgta tcatttgtgc aagttttgtg      1020
     atattttggt tgaataaacc tggtgaccca gaagtaaata gcaggacacc agaaaatgaa      1080
     cttaaaaagc tgagcaaata gacgaatcat tgggtttgag aggagaatag gattcatggg      1140
     ggaaatgggg aagaaatagc tagatttttc tctgaacaag cagcctatct catatgattg      1200
     gcttcaagag aggtttttgt tgaggggaaa gggtgagatc cctcactgtg gctcactttc      1260
     ggcggaggga ccaaggtgga gatcaaacgt aagtgcactt tcctaatgct ttttcttata      1320
     aggttttaaa tttggagcgt ttttgtgttt gagatattag ctcaggtcaa ttccaaagag      1380
     taccagattc tttcaaaaag tcagatgagt aagggataga aaattagttc atcttaagga      1440
     acagccaagc gctagccagt taagtgaggc atctcaattg caagattttc tctgcatcgg      1500
     tcaggttagt gatattaaca gcgaaaagag atttttgtta aggggaaagt aattaagtta      1560
     acactgtgga tcaccttcgg ccaagggaca cgactggaga ttaaacgtaa gtaatttttc      1620
     actattgtct tctgaaattt gggtctgatg gccagtattg acttttagag gcttaaatag      1680
     gagtttggta aagattggta aatgagggca tttaagattt gccatgggtt gcaaaagtta      1740
     aactcagctt caaaaatgga tttggagaaa aaaagattaa attgctctaa actgaatgac      1800
     acaaagtaaa aaaaaaaagt gtaactaaaa aggaaccctt gtatttctaa ggagcaaaag      1860
     taaatttatt tttgttcact cttgccaaat attgtattgg ttgttgctga ttatgcatga      1920
     tacagaaaag tggaaaaata cattttttag tctttctccc ttttgtttga taaattattt      1980
     tgtcagacaa caataaaaat caatagcacg ccctaagaaa aatcagggaa aagtgaagtg      2040
     tacctatttg ctatgtagaa gaggcagctt acttgaaaat cagcagcaat gttgttttta      2100
     gagtctgtaa taagtaataa actcaaaaag acacattcta taggaataag ggcttcacag      2160
     atagagctca ttttttaaaa atccaatttg tacattagac taaacgtgaa attatctctt      2220
     attgtaatgg tggaaaggtg gttattccca aaagctcaat ctcaaagaaa tgtgtttaaa      2280
     tgaaaaaaag taaataattg cattttttaa tgaccgtggg tctgtgaaaa aaataggaaa      2340
     tattttaaag agtatgttct ttcattatcc tctgttatta cttgtctaca tttttattct      2400
     gccaagaagg ccgtggcacc gcgagctgta gacagagccg cggtctttct cgattgagtg      2460
     gctttggtgg ccatgccacc gcgctcttgg ggcagccgcc ttgccgctat gccgtggcca      2520
     ccctgtgtct gcccgattaa tgctgccgta gccagctttc ctgatgcaca gtgatacaaa      2580
     taatgccact aagggaaaga gaacagaaac gtaatgggcg ctgagctggg aaaaccaggg      2640
     agaagactga tttattagag atttcagaaa taaaattcac attcattatg atatctcatt      2700
     agtgaaaatt tccattaggg gattgtaaat aatttaaagc tttttttttt tcagtgctat      2760
     ttaattattt caatatcctc tcatcaaatg tatttaaata acaaaagctc aaccaaaaag      2820
     aaagaaatat gtaattcttt cagagtaaaa atcacaccca tgacctggcc actgagggct      2880
     tgatcaattc actttgaatt tggcattaaa taccattaag gtatattaac tgattttaaa      2940
     ataagatata ttcgtgacca tgtttttaac tttcaaaaat gtagctgcca gtgtgtgatt      3000
     ttatttcagt tgtacaaaat atctaaacct atagcaatgt gattaataaa aacttaaaca      3060
     tattttccag taccttaatt ctgtgatagg aaaattttaa tctgagtatt ttaatttcat      3120
     aatctctaaa atagtttaat gatttgtcat tgtgttgctg tcgtttaccc cagctgatct      3180
     caaaagtgat atttaaggag attattttgg tctgcaacaa cttgatagga ctattttagg      3240
     gcctttttaa agctctatta aaactaactt acaacgattc aaaactgttt taaactattt      3300
     caaaatgatt ttagagcctt ttgaaaactc ttttaaacac tttttaaact ctattaaaac      3360
     taataagata acttgaaata attttcatgt caaatacatt aactgtttaa tgtttaaatg      3420
     ccagatgaaa aatgtaaagc tatcaagaat tcacccagat aggagtatct tcatagcatg      3480
     tttttccctg cttattttcc agtgatcaca ttattttgct accatggtta ttttatacaa      3540
     ttatctgaaa aaaattagtt atgaagatta aaagagaaga aaatattaaa cataagagat      3600
     tcagtctttc atgttgaact gcttggttaa cagtgaagtt agttttaaaa aaaaaaaaaa      3660
     ctatttctgt tatcagctga cttctcccta tctgttgact tctcccagca aaagattctt      3720
     attttacatt ttaacctact gctctcccac ccaacgggtg gaatccccca gagggggatt      3780
     tccaagaggc cacctggcag ttgctgaggg tcagaagtga agctagccac ttcctcttag      3840
     gcaggtggcc aagattacag ttgacctctc ctggtatggc tgaaaattgc tgcatatggt      3900
     tacaggcctt gaggcctttg ggagggctta gagagttgct ggaacagtca gaaggtggag      3960
     gggctgacac cacccaggcg cagaggcagg gctcagggcc tgctctgcag ggaggtttta      4020
     gcccagccca gccaaagtaa cccccgggag cctgttatcc cagcacagtc ctggaagagg      4080
     cacaggggaa ataaaagcgg acggaggctt tccttgactc agccgctgcc tggtcttctt      4140
     cagacctgtt ctgaattcta aactctgagg gggtcggatg acgtggccat tctttgccta      4200
     aagcattgag tttactgcaa ggtcagaaaa gcatgcaaag ccctcagaat ggctgcaaag      4260
     agctccaaca aaacaattta gaactttatt aaggaatagg gggaagctag gaagaaactc      4320
     aaaacatcaa gattttaaat acgcttcttg gtctccttgc tataattatc tgggataagc      4380
     atgctgtttt ctgtctgtcc ctaacatgcc ctgtgattat ccgcaaacaa cacacccaag      4440
     ggcagaactt tgttacttaa acaccatcct gtttgcttct ttcctcagga actgtggctg      4500
     caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga actgcctctg      4560
     ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg aaggtggata      4620
     acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc aaggacagca      4680
     cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct      4740
     acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc ttcaacaggg      4800
     gagagtgtta gagggagaag tgcccccacc tgctcctcag ttccagcctg accccctccc      4860
     atcctttggc ctctgaccct ttttccacag gggacctacc cctattgcgg tcctccagct      4920
     catctttcac ctcacccccc tcctcctcct tggctttaat tatgctaatg ttggaggaga      4980
     atgaataaat aaagtgaatc tttgcacctg tggtttctct ctttcctcaa tttaataatt      5040
     attatctgtt gtttaccaac tactcaattt ctcttataag ggactaaata tgtagtcatc      5100
     ctaaggcgca taaccattta taaaaatcat ccttcattct attttaccct atcatcctct      5160
     gcaagacagt cctccctcaa acccacaagc cttctgtcct cacagtcccc tgggccgtgg      5220
     taggagagac ttgcttcctt gttttcccct cctcagcaag ccctcatagt cctttttaag      5280
     ggtgacaggt cttacggtca tatatccttt gattcaattc cctgggaatc aaccaaggca      5340
     aatttttcaa aagaagaaac ctgc                                             5364
Created:
23/07/1995
Database development:
Denys CHAUME, Patrice DUROUX, Nelly JOUFFRE
Database scientific officer:
Marie-Paule Lefranc