IMGT/LIGM-DB logo
Database contains
247103 sequences
from 361 species

IMGT/LIGM-DB sequence

Version:
1.2.9
Database release:
LIGMDB_V12
Citing IMGT/LIGM-DB:
Giudicelli, V., Duroux P., Ginestoux C., Folch G., Jabado-Michaloud J., Chaume D., Lefranc M.-P., Nucleic Acids Res., 34:D781-D784 (2006). PMID:16381979 Abstract Full PDF

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Z12998 - Annotation

Sections
Accession number Z12998
Sequence version 1
Secondary accession numbers
IMGT annotation level by annotators
Definition O.aries rearranged T-cell receptor gamma
Species Ovis aries (sheep)
Taxonomy Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis; Ovis aries
Sequence length 604
IMGT/LIGM-DB dates 07-MAY-1996
  18-JAN-2013 (v. 7)

OBTENTION

Specificities
Disease related

IDENTIFICATION

Molecule type cDNA
Configuration type undefined, rearranged
Gene type constant, variable, joining
Molecule entity type L-V-J-C-sequence
Functionality type productive
Chain type TR-Gamma-TRG, TR-Gamma-1-TRGC1
Structure type regular
Location type
Other keywords antigen receptor, Immunoglobulin superfamily (IgSF), T cell receptor (TR), IMGT reference sequence

CLASSIFICATION

IMGT Groups TRGV
IMGT Subgroups TRGV1

DESCRIPTION

L-V-J-C-SEQUENCE   1..>604
  breed White Alpine
  cell_type pyrepheral lymphocytes
  dev_stage 1 year old normal animal
  organism Ovis aries
5'UTR   1..48
L-V-J-C-REGION   49..>604
atgttgtgggccctagtgctgcctttggttttcctggctcttgtcactcaggtatcttccaacgcaaaaggggcccagatgtcagtcactgctaagacttgggacactacttctttcacttgtgattttacacaagatgtcaaatatatccacctgtacaaacaacaggaggggatggctccccgacgtcttttctactacgatgtctactactccaagattgagttcgaatcaggaatcgataaagcaaaatacagtgtttataaaggtgcagcaggaaggagctacagatttgcaatcctaaatctggaacacagtgattctgggacgtactactgtgctgtctgggctggtagttacataaaaaacttcaacgttggaacaaaacttgtcgtcacagatagaaaccttgctacagacctttcacccaagcccattatttttcttccttcaattgctgaaatcaaccacagtaaaactggaacatacctttgtcttctggagaaatttttccctgatattattaaggtttattggaaagaaaaggatggcaaca M L W A L V L P L V F L A L V T Q V S S N A K G A Q M S V T A K T W D T T S F T C D F T Q D V K Y I H L Y K Q Q E G M A P R R L F Y Y D V Y Y S K I E F E S G I D K A K Y S V Y K G A A G R S Y R F A I L N L E H S D S G T Y Y C A V W A G S Y I K N F N V G T K L V V T D R N L A T D L S P K P I I F L P S I A E I N H S K T G T Y L C L L E K F F P D I I K V Y W K E K D G N
C C G P * C C L W F S W L L S L R Y L P T Q K G P R C Q S L L R L G T L L L S L V I L H K M S N I S T C T N N R R G W L P D V F S T T M S T T P R L S S N Q E S I K Q N T V F I K V Q Q E G A T D L Q S * I W N T V I L G R T T V L S G L V V T * K T S T L E Q N L S S Q I E T L L Q T F H P S P L F F F L Q L L K S T T V K L E H T F V F W R N F S L I L L R F I G K K R M A T
V V G P S A A F G F P G S C H S G I F Q R K R G P D V S H C * D L G H Y F F H L * F Y T R C Q I Y P P V Q T T G G D G S P T S F L L R C L L L Q D * V R I R N R * S K I Q C L * R C S R K E L Q I C N P K S G T Q * F W D V L L C C L G W * L H K K L Q R W N K T C R H R * K P C Y R P F T Q A H Y F S S F N C * N Q P Q * N W N I P L S S G E I F P * Y Y * G L L E R K G W Q
L-V-J-REGION   49..447
atgttgtgggccctagtgctgcctttggttttcctggctcttgtcactcaggtatcttccaacgcaaaaggggcccagatgtcagtcactgctaagacttgggacactacttctttcacttgtgattttacacaagatgtcaaatatatccacctgtacaaacaacaggaggggatggctccccgacgtcttttctactacgatgtctactactccaagattgagttcgaatcaggaatcgataaagcaaaatacagtgtttataaaggtgcagcaggaaggagctacagatttgcaatcctaaatctggaacacagtgattctgggacgtactactgtgctgtctgggctggtagttacataaaaaacttcaacgttggaacaaaacttgtcgtcaca M L W A L V L P L V F L A L V T Q V S S N A K G A Q M S V T A K T W D T T S F T C D F T Q D V K Y I H L Y K Q Q E G M A P R R L F Y Y D V Y Y S K I E F E S G I D K A K Y S V Y K G A A G R S Y R F A I L N L E H S D S G T Y Y C A V W A G S Y I K N F N V G T K L V V T
C C G P * C C L W F S W L L S L R Y L P T Q K G P R C Q S L L R L G T L L L S L V I L H K M S N I S T C T N N R R G W L P D V F S T T M S T T P R L S S N Q E S I K Q N T V F I K V Q Q E G A T D L Q S * I W N T V I L G R T T V L S G L V V T * K T S T L E Q N L S S
V V G P S A A F G F P G S C H S G I F Q R K R G P D V S H C * D L G H Y F F H L * F Y T R C Q I Y P P V Q T T G G D G S P T S F L L R C L L L Q D * V R I R N R * S K I Q C L * R C S R K E L Q I C N P K S G T Q * F W D V L L C C L G W * L H K K L Q R W N K T C R H
L-V-REGION   49..399
  putative_limit 3' side
atgttgtgggccctagtgctgcctttggttttcctggctcttgtcactcaggtatcttccaacgcaaaaggggcccagatgtcagtcactgctaagacttgggacactacttctttcacttgtgattttacacaagatgtcaaatatatccacctgtacaaacaacaggaggggatggctccccgacgtcttttctactacgatgtctactactccaagattgagttcgaatcaggaatcgataaagcaaaatacagtgtttataaaggtgcagcaggaaggagctacagatttgcaatcctaaatctggaacacagtgattctgggacgtactactgtgctgtctgggct M L W A L V L P L V F L A L V T Q V S S N A K G A Q M S V T A K T W D T T S F T C D F T Q D V K Y I H L Y K Q Q E G M A P R R L F Y Y D V Y Y S K I E F E S G I D K A K Y S V Y K G A A G R S Y R F A I L N L E H S D S G T Y Y C A V W A
C C G P * C C L W F S W L L S L R Y L P T Q K G P R C Q S L L R L G T L L L S L V I L H K M S N I S T C T N N R R G W L P D V F S T T M S T T P R L S S N Q E S I K Q N T V F I K V Q Q E G A T D L Q S * I W N T V I L G R T T V L S G
V V G P S A A F G F P G S C H S G I F Q R K R G P D V S H C * D L G H Y F F H L * F Y T R C Q I Y P P V Q T T G G D G S P T S F L L R C L L L Q D * V R I R N R * S K I Q C L * R C S R K E L Q I C N P K S G T Q * F W D V L L C C L G
L-REGION   49..102
atgttgtgggccctagtgctgcctttggttttcctggctcttgtcactcaggta M L W A L V L P L V F L A L V T Q V
C C G P * C C L W F S W L L S L R
V V G P S A A F G F P G S C H S G
INIT-CODON   49..51
V-J-C-REGION   103..>604
tcttccaacgcaaaaggggcccagatgtcagtcactgctaagacttgggacactacttctttcacttgtgattttacacaagatgtcaaatatatccacctgtacaaacaacaggaggggatggctccccgacgtcttttctactacgatgtctactactccaagattgagttcgaatcaggaatcgataaagcaaaatacagtgtttataaaggtgcagcaggaaggagctacagatttgcaatcctaaatctggaacacagtgattctgggacgtactactgtgctgtctgggctggtagttacataaaaaacttcaacgttggaacaaaacttgtcgtcacagatagaaaccttgctacagacctttcacccaagcccattatttttcttccttcaattgctgaaatcaaccacagtaaaactggaacatacctttgtcttctggagaaatttttccctgatattattaaggtttattggaaagaaaaggatggcaaca S S N A K G A Q M S V T A K T W D T T S F T C D F T Q D V K Y I H L Y K Q Q E G M A P R R L F Y Y D V Y Y S K I E F E S G I D K A K Y S V Y K G A A G R S Y R F A I L N L E H S D S G T Y Y C A V W A G S Y I K N F N V G T K L V V T D R N L A T D L S P K P I I F L P S I A E I N H S K T G T Y L C L L E K F F P D I I K V Y W K E K D G N
L P T Q K G P R C Q S L L R L G T L L L S L V I L H K M S N I S T C T N N R R G W L P D V F S T T M S T T P R L S S N Q E S I K Q N T V F I K V Q Q E G A T D L Q S * I W N T V I L G R T T V L S G L V V T * K T S T L E Q N L S S Q I E T L L Q T F H P S P L F F F L Q L L K S T T V K L E H T F V F W R N F S L I L L R F I G K K R M A T
F Q R K R G P D V S H C * D L G H Y F F H L * F Y T R C Q I Y P P V Q T T G G D G S P T S F L L R C L L L Q D * V R I R N R * S K I Q C L * R C S R K E L Q I C N P K S G T Q * F W D V L L C C L G W * L H K K L Q R W N K T C R H R * K P C Y R P F T Q A H Y F S S F N C * N Q P Q * N W N I P L S S G E I F P * Y Y * G L L E R K G W Q
V-J-REGION   103..447
tcttccaacgcaaaaggggcccagatgtcagtcactgctaagacttgggacactacttctttcacttgtgattttacacaagatgtcaaatatatccacctgtacaaacaacaggaggggatggctccccgacgtcttttctactacgatgtctactactccaagattgagttcgaatcaggaatcgataaagcaaaatacagtgtttataaaggtgcagcaggaaggagctacagatttgcaatcctaaatctggaacacagtgattctgggacgtactactgtgctgtctgggctggtagttacataaaaaacttcaacgttggaacaaaacttgtcgtcaca S S N A K G A Q M S V T A K T W D T T S F T C D F T Q D V K Y I H L Y K Q Q E G M A P R R L F Y Y D V Y Y S K I E F E S G I D K A K Y S V Y K G A A G R S Y R F A I L N L E H S D S G T Y Y C A V W A G S Y I K N F N V G T K L V V T
L P T Q K G P R C Q S L L R L G T L L L S L V I L H K M S N I S T C T N N R R G W L P D V F S T T M S T T P R L S S N Q E S I K Q N T V F I K V Q Q E G A T D L Q S * I W N T V I L G R T T V L S G L V V T * K T S T L E Q N L S S
F Q R K R G P D V S H C * D L G H Y F F H L * F Y T R C Q I Y P P V Q T T G G D G S P T S F L L R C L L L Q D * V R I R N R * S K I Q C L * R C S R K E L Q I C N P K S G T Q * F W D V L L C C L G W * L H K K L Q R W N K T C R H
V-REGION   103..399
  IMGT_gene TRGV1
  putative_limit 3' side
tcttccaacgcaaaaggggcccagatgtcagtcactgctaagacttgggacactacttctttcacttgtgattttacacaagatgtcaaatatatccacctgtacaaacaacaggaggggatggctccccgacgtcttttctactacgatgtctactactccaagattgagttcgaatcaggaatcgataaagcaaaatacagtgtttataaaggtgcagcaggaaggagctacagatttgcaatcctaaatctggaacacagtgattctgggacgtactactgtgctgtctgggct S S N A K G A Q M S V T A K T W D T T S F T C D F T Q D V K Y I H L Y K Q Q E G M A P R R L F Y Y D V Y Y S K I E F E S G I D K A K Y S V Y K G A A G R S Y R F A I L N L E H S D S G T Y Y C A V W A
L P T Q K G P R C Q S L L R L G T L L L S L V I L H K M S N I S T C T N N R R G W L P D V F S T T M S T T P R L S S N Q E S I K Q N T V F I K V Q Q E G A T D L Q S * I W N T V I L G R T T V L S G
F Q R K R G P D V S H C * D L G H Y F F H L * F Y T R C Q I Y P P V Q T T G G D G S P T S F L L R C L L L Q D * V R I R N R * S K I Q C L * R C S R K E L Q I C N P K S G T Q * F W D V L L C C L G
FR1-IMGT   103..180
  AA_IMGT 1 to 26
tcttccaacgcaaaaggggcccagatgtcagtcactgctaagacttgggacactacttctttcacttgtgattttaca S S N A K G A Q M S V T A K T W D T T S F T C D F T
L P T Q K G P R C Q S L L R L G T L L L S L V I L
F Q R K R G P D V S H C * D L G H Y F F H L * F Y
1st-CYS   169..171
CDR1-IMGT   181..195
  AA_IMGT AA 27 to 38, AA 30, 31, 32, 33, 34, 35 and 36 are missing
caagatgtcaaatat Q D V K Y
K M S N
R C Q I
FR2-IMGT   196..246
  AA_IMGT 39 to 55
  note conserved TRP is replaced by LEU: ctg instead of tgg
atccacctgtacaaacaacaggaggggatggctccccgacgtcttttctac I H L Y K Q Q E G M A P R R L F Y
S T C T N N R R G W L P D V F S
P P V Q T T G G D G S P T S F L
CDR2-IMGT   247..270
  AA_IMGT AA 56 to 65, AA 60 and 61 are missing
tacgatgtctactactccaagatt Y D V Y Y S K I
T M S T T P R
R C L L L Q D
FR3-IMGT   271..387
  AA_IMGT 66 to 104
gagttcgaatcaggaatcgataaagcaaaatacagtgtttataaaggtgcagcaggaaggagctacagatttgcaatcctaaatctggaacacagtgattctgggacgtactactgt E F E S G I D K A K Y S V Y K G A A G R S Y R F A I L N L E H S D S G T Y Y C
S S N Q E S I K Q N T V F I K V Q Q E G A T D L Q S * I W N T V I L G R T T
V R I R N R * S K I Q C L * R C S R K E L Q I C N P K S G T Q * F W D V L L
2nd-CYS   385..387
CDR3-IMGT   388..423
  AA_IMGT AA 105 to 117, AA 111 is missing
gctgtctgggctggtagttacataaaaaacttcaac A V W A G S Y I K N F N
L S G L V V T * K T S
C L G W * L H K K L Q
JUNCTION   385..426
tgtgctgtctgggctggtagttacataaaaaacttcaacgtt C A V W A G S Y I K N F N V
V L S G L V V T * K T S T
C C L G W * L H K K L Q R
N-REGION   400..402
J-REGION   403..447
  gene TRGJ1
agttacataaaaaacttcaacgttggaacaaaacttgtcgtcaca S Y I K N F N V G T K L V V T
V T * K T S T L E Q N L S S
L H K K L Q R W N K T C R H
C-REGION   448..>604
  IMGT_gene TRGC1
gatagaaaccttgctacagacctttcacccaagcccattatttttcttccttcaattgctgaaatcaaccacagtaaaactggaacatacctttgtcttctggagaaatttttccctgatattattaaggtttattggaaagaaaaggatggcaaca D R N L A T D L S P K P I I F L P S I A E I N H S K T G T Y L C L L E K F F P D I I K V Y W K E K D G N
I E T L L Q T F H P S P L F F F L Q L L K S T T V K L E H T F V F W R N F S L I L L R F I G K K R M A T
* K P C Y R P F T Q A H Y F S S F N C * N Q P Q * N W N I P L S S G E I F P * Y Y * G L L E R K G W Q
EX1   448..>604
gatagaaaccttgctacagacctttcacccaagcccattatttttcttccttcaattgctgaaatcaaccacagtaaaactggaacatacctttgtcttctggagaaatttttccctgatattattaaggtttattggaaagaaaaggatggcaaca D R N L A T D L S P K P I I F L P S I A E I N H S K T G T Y L C L L E K F F P D I I K V Y W K E K D G N
I E T L L Q T F H P S P L F F F L Q L L K S T T V K L E H T F V F W R N F S L I L L R F I G K K R M A T
* K P C Y R P F T Q A H Y F S S F N C * N Q P Q * N W N I P L S S G E I F P * Y Y * G L L E R K G W Q

Literature references

[2] 1-604
Hein W.R.
Submitted to the ENA/GenBank/DDBJ databases (15-JUN-1992)
Wayne R. Hein, Basel Institute for Immunology, Grenzacherstrasse, 487, CH-4058 Basel, Switzerland
[3] 1-604
Hein W.R., Dudler L.
Divergent evolution of the T cell repertoire : extensive diversity and developmentally regulated expression of the sheep gamma/delta T cell receptor
EMBO J. 12:712-724 (1993)

Database cross-references

Database Identifiers Relation
ENA Z12998

Sequence

Length : 604 BP
Composition : 172 A; 139 C; 123 G; 170 T; 0 other

     ggcctgtcac atctgctgag aaccccagtc tagctcactg tcccaggcat gttgtgggcc        60
     ctagtgctgc ctttggtttt cctggctctt gtcactcagg tatcttccaa cgcaaaaggg       120
     gcccagatgt cagtcactgc taagacttgg gacactactt ctttcacttg tgattttaca       180
     caagatgtca aatatatcca cctgtacaaa caacaggagg ggatggctcc ccgacgtctt       240
     ttctactacg atgtctacta ctccaagatt gagttcgaat caggaatcga taaagcaaaa       300
     tacagtgttt ataaaggtgc agcaggaagg agctacagat ttgcaatcct aaatctggaa       360
     cacagtgatt ctgggacgta ctactgtgct gtctgggctg gtagttacat aaaaaacttc       420
     aacgttggaa caaaacttgt cgtcacagat agaaaccttg ctacagacct ttcacccaag       480
     cccattattt ttcttccttc aattgctgaa atcaaccaca gtaaaactgg aacatacctt       540
     tgtcttctgg agaaattttt ccctgatatt attaaggttt attggaaaga aaaggatggc       600
     aaca                                                                    604
Created:
23/07/1995
Database development:
Denys CHAUME, Patrice DUROUX, Nelly JOUFFRE
Database scientific officer:
Marie-Paule Lefranc