IMGT/mAb-DB card

Version: 2.0.4 (2023-04-14)

Citing IMGT/mAb-DB

Manso T., Kushwaha A., Abdollahi N., Duroux P., Giudicelli V. and Kossida S. Mechanisms of action of monoclonal antibodies in oncology integrated in IMGT/mAb-DB. Front Immunol., 14 (2023). DOI 10.3389/fimmu.2023.1129323

Poiron C., Wu Y., Ginestoux C., Ehrenmann, Duroux P. and Lefranc M.-P. IMGT/mAb-DB: the IMGT® database for therapeutic monoclonal antibodies. JOBIM 2010, Paper 13 (2010). Abstract

Cambon M., Cherouali K., Kushwaha A., Giudicelli V., Duroux P., Kossida S. and Lefranc M.-P. IMGT/mAb-DB and IMGT/2Dstructure-DB for IMGT standard definition of an antibody: from receptor to amino acid changes. JOBIM 2018, Poster 201 (2018). Abstract

IMGT/mAb-DB ID	463
INN	eldelumab
INN Number	9746
INN Prop. List	109 (2013)
INN Rec. List	71 (2014)
Common name	BMS-936557, MDX-1100
Proprietary name
Species	Homo sapiens
IMGT receptor type	IG
Format (legend)
Receptor identification	IgG1 - kappa
Radiolabelled / Conjugated / Fused
IMGT/2Dstructure-DB	9746
IMGT/3Dstructure-DB
Specificity target name and species	CXCL10 (chemokine C-X-C motif ligand 10, 10 kDa interferon gamma-induced protein gamma-IP10, IP-10, INP10, small inducible cytokine B10, SCYB10) [Homo sapiens]
Development Technology	Medarex's UltiMAb®
Origin clone species
Origin clone name

Company	Bristol-Myers Squibb (Princeton NJ USA)
Expression system	CHO (Chinese Hamster Ovary) cells
Application
Clinical domain	Immunology
Mechanism of action
Clinical indication	Rheumatoid arthritis (RA)
Development status	Phase II
Regulatory agency status and year

Company	Bristol-Myers Squibb (Princeton NJ USA)
Expression system	CHO (Chinese Hamster Ovary) cells
Application
Clinical domain	Immunology
Mechanism of action
Clinical indication	Colitis, ulcerative (UC)
Development status	Phase II
Regulatory agency status and year

Clinical trials
Authority decisions
External links
IMGT notes	Originally developed at Ability Biomedical (acquired by Medarex in 2004). In 2009, Medarex was acuired by Bristol-Myers-Squibb.
Biosimilars

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