Lengths of the G-DOMAIN and G-LIKE-DOMAIN labels [1] are given according to the IMGT unique numbering for G-DOMAIN and G-LIKE-DOMAIN.
Hs: Homo sapiens
Mm: Mus musculus
G-ALPHA1 [D1] | G-ALPHA1-LIKE [D1] | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
MH1-a | MH1-b | RPI-MH1-like | ||||||||||
G-DOMAIN and G-LIKE-DOMAIN labels |
IMGT unique numbering |
Domain maximal length |
HLA-A HLA-B HLA-C |
H2-D1 MH1-K1 H2-L |
HLA-E HLA-F HLA-G |
H2-M5 H2-Q7 H2-T3 |
MICA | MR1 | RAET1N | AZGP1 | CD1D1 | FCGRT |
Hs | Mm | Hs | Mm | Hs | Hs | Hs | Mm | Mm | Mm | |||
A-STRAND | 1.3-1.1(1) | +3 | +3 | +1 | ||||||||
1-14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | |
7A | +1 | |||||||||||
AB-TURN | 15-17 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 2 | 3 |
B-STRAND | 18-28 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 |
BC-TURN | 29-30 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
C-STRAND | 31-38 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
CD-TURN | 39-41 | 3 | 3 | 3 | 3 | 3 | 1 | 1 | 1 | 1 | 1 | 1 |
D-STRAND | 42-49 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
49.1-49.5 | +5 | |||||||||||
HELIX | 50-92 | 43 | 41 | 41 | 41 | 41 | 37 | 39 | 40 | 40 | 41 | 37 |
54A | +1 | +1 | +1 | +1 | +1 | +1 | ||||||
61A | +1 | |||||||||||
61B | +1 | |||||||||||
72A | +1 | |||||||||||
92A | +1 | |||||||||||
Total domain length | 92 (+14) | 90 | 90 | 90 | 90 | 86 (+1) | 88 (+1) | 89 (+1) | 89 | 90 (+4) | 86 (+2) |
G-ALPHA [D1] | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
MH2-a | MH2-b | |||||||||
G-DOMAIN and G-LIKE-DOMAIN labels |
IMGT unique numbering |
Domain maximal length |
HLA-DPA1 HLA-DRA |
HLA-DQA1 | MH2-AA | H2-EA | HLA-DMA | HLA-DOA | H2-DMA | H2-DOA |
Hs | Hs | Mm | Mm | Hs | Hs | Mm | Mm | |||
A-STRAND | 1.10-1.1(1) | +10 | +2 | +2 | +2 | +2 | +10 | +2 | +10 | +2 |
1-14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | |
7A | +1 | +1 | +1 | +1 | +1 | |||||
AB-TURN | 15-17 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
B-STRAND | 18-28 | 11 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
BC-TURN | 29-30 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
C-STRAND | 31-38 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
CD-TURN | 39-41 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
D-STRAND | 42-49 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
49.1-49.5 | +5 | |||||||||
HELIX | 50-92 | 43 | 39 | 38 | 39 | 39 | 39 | 39 | 39 | 39 |
54A | +1 | |||||||||
61A | +1 | +1 | +1 | |||||||
61B | +1 | +1 | +1 | |||||||
72A | +1 | |||||||||
92A | +1 | +1 | +1 | |||||||
Total domain length | 92 (+21) | 82 (+2) | 81 (+3) | 82 (+3) | 82 (+2) | 82 (+13) | 82 (+3) | 82 (+13) | 82 (+3) |
G-ALPHA2 [D2] | G-ALPHA2-LIKE [D2] | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
MH1-a | MH1b | RPI-MH1-like | ||||||||||
G-DOMAIN and G-LIKE-DOMAIN labels |
IMGT unique numbering |
Domain maximal length |
HLA-A HLA-B HLA-C |
H2-D1 MH1-K1 H2-L |
HLA-E HLA-F HLA-G |
H2-M5 H2-Q7 H2-T3 |
MICA | MR1 | RAET1N | AZGP1 | CD1D1 | FCGRT |
Hs | Mm | Hs | Mm | Hs | Hs | Hs | Mm | Mm | Mm | |||
A-STRAND | 1-14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 |
7A | +1 | |||||||||||
AB-TURN | 15-17 | 3 | 3 | 3 | 3 | 3 | 2 | 2 | 2 | 2 | 2 | 2 |
B-STRAND | 18-28 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 |
BC-TURN | 29-30 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
C-STRAND | 31-38 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
CD-TURN | 39-41 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 |
D-STRAND | 42-49 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 7 | 8 |
49.1-49.5 | +5 | +5 | +3 | |||||||||
HELIX | 50-92 | 43 | 43 | 43 | 43 | 43 | 42 | 43 | 43 | 43 | 43 | 43 |
54A | +1 | |||||||||||
61A | +1 | +1 | +1 | +1 | +1 | +1 | +1 | +1 | +1 | +1 | +1 | |
61B | +1 | +1 | +1 | +1 | +1 | +1 | +1 | |||||
72A | +1 | +1 | +1 | +1 | +1 | +1 | +1 | +1 | +1 | +1 | +1 | |
92A | +1 | |||||||||||
Total domain length | 92 (+11) | 90 (+2) | 90 (+2) | 90 (+2) | 90 (+2) | 88 (+8) | 89 (+3) | 89 (+3) | 89 (+3) | 87 (+6) | 89 (+3) |
G-BETA [D1] | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
MH2-a | MH2-b | |||||||||
G-DOMAIN and G-LIKE-DOMAIN labels | IMGT unique numbering | Domain maximal length | HLA-DPB1 | HLA-DQB1 HLA-DRB1 |
H2-AB | H2-EB1 | HLA-DMB | HLA-DOB | H2-DMB1 | H2-DOB |
Hs | Hs | Mm | Mm | Hs | Hs | Mm | Mm | |||
A-STRAND | 1-14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 |
7A | +1 | |||||||||
AB-TURN | 15-17 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
B-STRAND | 18-28 | 11 | 9 | 11 | 11 | 11 | 11 | 11 | 11 | 11 |
BC-TURN | 29-30 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
C-STRAND | 31-38 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
CD-TURN | 39-41 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
D-STRAND | 42-49 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
49.1-49.5 | +5 | +4 | +4 | |||||||
HELIX | 50-92 | 43 | 40 | 40 | 41 | 40 | 40 | 40 | 40 | 40 |
54A | +1 | |||||||||
61A | +1 | +1 | +1 | +1 | +1 | +1 | +1 | +1 | ||
61B | +1 | +1 | +1 | +1 | +1 | +1 | +1 | +1 | ||
72A | +1 | +1 | +1 | +1 | +1 | +1 | +1 | +1 | +1 | |
92A | +1 | |||||||||
Total domain length | 92 (+11) | 85 (+3) | 87 (+3) | 88 (+1) | 87 (+3) | 87 (+7) | 87 (+3) | 87 (+7) | 87 (+3) |
(+) | A plus sign indicates additional positions described in [1]. |
(1) | The amino acids at positions 1.2 and 1.1 for HLA-DRA were identified by amino acid sequencing [2] and extrapolated for the G-ALPHA [D1] domains of the other MH2-a chains and for the MH2-b HLA-DQA and H2-DQA chains. These additional amino acids, and those at positions 1.10-1.1 of the G-ALPHA [D1] domain of the HLA-DMA and H2-DMA chains, need to be confirmed experimentally in the mature chain. This also concerns positions 1.3-1.1 of the G-ALPHA1-LIKE [D1] domain of the Mus musculus CD1D1 and positions 1.1 of Mus musculus FCGRT. |
[1] | Lefranc M.-P. et al., Dev. Comp. Immunol., 29, 917-938 (2005) PMID: 15936075 with permission from Elsevier |
[2] | Larhammar, D. et al., Cell, 30, 153-161 (1982). |