Correspondence is shown with the amino acid numbering of the mature MICA I-ALPHA-LIKE chain.
| MICA G-ALPHA1-LIKE [D1] and G-ALPHA2-LIKE [D2] domains | |||
|---|---|---|---|
| IMGT labels | IMGT unique numbering for G-DOMAIN and G-LIKE-DOMAIN [1] |
MICA*01 | |
| G-ALPHA1-LIKE domain [D1] |
G-ALPHA2-LIKE domain [D2] |
||
| A-STRAND | 1 | 1 (g)ag (GLU) (E) | 86 (g)gc (GLY) (G) |
| 2 | 2 ccc PRO P | 87 ttg LEU L | |
| 3 | 3 cac HIS H | 88 cat HIS H | |
| 4 | 4 agt SER S | 89 tcc SER S | |
| 5 | 5 ctt LEU L | 90 ctc LEU L | |
| 6 | 6 cgt ARG R | 91 cag GLN Q | |
| 7 | 7 tat TYR Y | 92 gag GLU E | |
| 7A | --- --- - | --- --- - | |
| 8 | 8 aac ASN N | 93 att ILE I | |
| 9 | 9 ctc LEU L | 94 agg ARG R | |
| 10 | 10 acg THR T | 95 gtc VAL V | |
| 11 | 11 gtg VAL V | 96 tgt CYS C | |
| 12 | 12 ctg LEU L | 97 gag GLU E | |
| 13 | 13 tcc SER S | 98 atc ILE I | |
| 14 | 14 tgg TRP W | 99 cat HIS H | |
| AB-TURN | 15 | 15 gat ASP D | 100 gaa GLU E |
| 16 | 16 gga GLY G | 101 gac ASP D | |
| 17 | 17 tct SER S | --- --- - | |
| B-STRAND | 18 | 18 gtg VAL V | 102 aac ASN N |
| 19 | 19 cag GLN Q | 103 agc SER S | |
| 20 | 20 tca SER S | 104 acc THR T | |
| 21 | 21 ggg GLY G | 105 agg ARG R | |
| 22 | 22 ttt PHE F | 106 agc SER S | |
| 23 | 23 ctc LEU L | 107 tcc SER S | |
| 24 | 24 act THR T | 108 cag GLN Q | |
| 25 | 25 gag GLU E | 109 cat HIS H | |
| 26 | 26 gta VAL V | 110 ttc PHE F | |
| 27 | 27 cat HIS H | 111 tac TYR Y | |
| 28 | 28 ctg LEU L | 112 tac TYR Y | |
| BC-TURN | 29 | 29 gat ASP D | 113 gat ASP D |
| 30 | 30 ggt GLY G | 114 ggg GLY G | |
| C-STRAND | 31 | 31 cag GLN Q | 115 gag GLU E |
| 32 | 32 ccc PRO P | 116 ctc LEU L | |
| 33 | 33 ttc PHE F | 117 ttc PHE F | |
| 34 | 34 ctg LEU L | 118 ctc LEU L | |
| 35 | 35 cgc ARG R | 119 tcc SER S | |
| 36 | 36 tgt CYS C | 120 caa GLN Q | |
| 37 | 37 gac ASP D | 121 aac ASN N | |
| 38 | 38 agg ARG R | 122 ctg LEU L | |
| CD-TURN | 39 | 39 cag GLN Q | 123 gag GLU E |
| 40 | --- --- - | --- --- - | |
| 41 | --- --- - | --- --- - | |
| D-STRAND | 42 | 40 aaa LYS K | 124 act THR T |
| 43 | 41 tgc CYS C | 125 aag LYS K | |
| 44 | 42 agg ARG R | 126 gaa GLU E | |
| 45 | 43 gca ALA A | 127 tgg TRP W | |
| 46 | 44 aag LYS K | 128 aca THR T | |
| 47 | 45 ccc PRO P | 129 atg MET M | |
| 48 | 46 cag GLN Q | 130 ccc PRO P | |
| 49 | 47 gga GLY G | 131 cag GLN Q | |
| 49.1 | --- --- - | 132 tcc SER S | |
| 49.2 | --- --- - | 133 tcc SER S | |
| 49.3 | --- --- - | 134 aga ARG R | |
| 49.4 | --- --- - | 135 gct ALA A | |
| 49.5 | --- --- - | 136 cag GLN Q | |
| Helix | 50 | 48 cag GLN Q | 137 acc THR T |
| 51 | 49 tgg TRP W | 138 ttg LEU L | |
| 52 | 50 gca ALA A | 139 gcc ALA A | |
| 53 | 51 gaa GLU E | 140 atg MET M | |
| 54 | 52 gat ASP D | 141 aac ASN N | |
| 54A | 53 gtc VAL V | --- --- - | |
| 55 | 54 ctg LEU L | 142 gtc VAL V | |
| 56 | 55 gga GLY G | 143 agg ARG R | |
| 57 | 56 aat ASN N | 144 aat ASN N | |
| 58 | 57 aag LYS K | 145 ttc PHE F | |
| 59 | 58 aca THR T | 146 ttg LEU L | |
| 60 | 59 tgg TRP W | 147 aag LYS K | |
| 61 | 60 gac ASP D | 148 gaa GLU E | |
| 61A | --- --- - | 149 gat ASP D | |
| 61B | --- --- - | 150 gcc ALA A | |
| 62 | 61 aga ARG R | 151 atg MET M | |
| 63 | 62 gag GLU E | 152 aag LYS K | |
| 64 | 63 acc THR T | 153 acc THR T | |
| 65 | 64 aga ARG R | 154 aag LYS K | |
| 66 | 65 gac ASP D | 155 aca THR T | |
| 67 | 66 ttg LEU L | 156 cac HIS H | |
| 68 | 67 aca THR T | 157 tat TYR Y | |
| 69 | 68 ggg GLY G | 158 cac HIS H | |
| 70 | 69 aac ASN N | 159 gct ALA A | |
| 71 | 70 gga GLY G | 160 atg MET M | |
| 72 | 71 aag LYS K | 161 cat HIS H | |
| 72A | --- --- - | 162 gca ALA A | |
| 73 | 72 gac ASP D | 163 gac ASP D | |
| 74 | 73 ctc LEU L | 164 tgc CYS C | |
| 75 | 74 agg ARG R | 165 ctg LEU L | |
| 76 | 75 atg MET M | 166 cag GLN Q | |
| 77 | 76 acc THR T | 167 gaa GLU E | |
| 78 | 77 ctg LEU L | 168 cta LEU L | |
| 79 | 78 gct ALA A | 169 cgg ARG R | |
| 80 | 79 cat HIS H | 170 cga ARG R | |
| 81 | 80 atc ILE I | 171 tat TYR Y | |
| 82 | 81 aag LYS K | 172 cta LEU L | |
| 83 | 82 gac ASP D | 173 aaa LYS K | |
| 84 | 83 cag GLN Q | 174 tcc SER S | |
| 85 | 84 aaa LYS K | 175 ggc GLY G | |
| 86 | 85 gaa GLU E | 176 gta VAL V | |
| 87 | --- --- - | --- --- - | |
| 88 | --- --- - | 177 gtc VAL V | |
| 89 | --- --- - | 178 ctg LEU L | |
| 90 | --- --- - | 179 agg ARG R | |
| 91 | --- --- - | 180 aga ARG R | |
| 92 | --- --- - | 181 aca THR T | |
| 92A | --- --- - | --- --- - | |
⇑ Top
| MICA C-LIKE-DOMAIN [D3] | |||
|---|---|---|---|
| IMGT labels | IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN [2] |
MICA*01 C-LIKE-DOMAIN [D3] (1) |
|
| A-STRAND | 1.1 | 182 1 (g)tg (VAL) (V) | |
| 1 | 183 2 ccc PRO P | ||
| 2 | 184 3 ccc PRO P | ||
| 3 | 185 4 atg MET M | ||
| 4 | 186 5 gtg VAL V | ||
| 5 | 187 6 att ASN N | ||
| 6 | 188 7 gtc VAL V | ||
| 7 | 189 8 acc THR T | ||
| 8 | 190 9 cgc ARG R | ||
| 9 | 191 10 agc SER S | ||
| 10 | 192 11 gag GLU E | ||
| 11 | 193 12 gcc ALA A | ||
| 12 | 194 13 tca SER S | ||
| 13 | 195 14 gag GLU E | ||
| 14 | --- --- - | ||
| 15 | --- --- - | ||
| AB-TURN | 15.1 | --- --- - | |
| 15.2 | --- --- - | ||
| 15.3 | --- --- - | ||
| B-STRAND | 16 | --- --- - | |
| 17 | 196 15 ggc GLY G | ||
| 18 | 197 16 aac ASN N | ||
| 19 | 198 17 att ILE I | ||
| 20 | 199 18 acc THR T | ||
| 21 | 200 19 gtg VAL V | ||
| 22 | 201 20 aca THR T | ||
| 23 | 202 21 tgc CYS C | ||
| 24 | 203 22 agg ARG R | ||
| 25 | 204 23 gct ALA A | ||
| 26 | 205 24 tct SER S | ||
| BC-LOOP | 27 | 206 25 ggc GLY G | |
| 28 | 207 26 ttc PHE F | ||
| 29 | 208 27 tat TYR Y | ||
| 30 | 209 28 ccc PRO P | ||
| 31 | --- --- - | ||
| 32 | --- --- - | ||
| 33 | 210 29 tgg TRP W | ||
| 34 | 211 30 aat ASN N | ||
| 35 | 212 31 atc ILE I | ||
| 36 | 213 32 aca THR T | ||
| C-STRAND | 39 | 214 33 ctg LYS K | |
| 40 | 215 34 agc S SER | ||
| 41 | 216 35 tgg TRP W | ||
| 42 | 217 36 cgt ARG R | ||
| 43 | 218 37 cag GLN Q | ||
| 44 | 219 38 gat ASP D | ||
| 45 | 220 39 ggg GLY G | ||
| CD-STRAND | 45.1 | 221 40 gta VAL V | |
| 45.2 | 222 41 tct SER S | ||
| 45.3 | 223 42 ttg LEU L | ||
| 45.4 | 224 43 agc S SER | ||
| 45.5 | 225 44 cac HIS H | ||
| 45.6 | 226 45 gac ASP D | ||
| 45.7 | --- --- - | ||
| D-STRAND | 77 | 227 46 acc THR T | |
| 78 | 228 47 cag GLN Q | ||
| 79 | 229 48 cag GLN Q | ||
| 80 | 230 49 tgg TRP W | ||
| 81 | 231 50 ggg GLY G | ||
| 82 | 232 51 gat ASP S | ||
| 83 | 233 52 gtc VAL V | ||
| 84 | 234 53 ctg LEU L | ||
| DE-TURN | 84.1 | 235 54 cct PRO P | |
| 84.2 | 236 55 gat ASP D | ||
| 84.3 | 237 56 ggg GLY G | ||
| 84.4 | 238 57 aat ASN N | ||
| 84.5 | --- --- - | ||
| 84.6 | --- --- - | ||
| 84.7 | --- --- - | ||
| 85.7 | --- --- - | ||
| 85.6 | --- --- - | ||
| 85.5 | --- --- - | ||
| 85.4 | 239 58 gga GLY G | ||
| 85.3 | 240 59 acc THR T | ||
| 85.2 | 241 60 tac TYR Y | ||
| 85.1 | 242 61 cag GLN Q | ||
| E-STRAND | 85 | 243 62 acc THR T | |
| 86 | 244 63 tgg TRP W | ||
| 87 | 245 64 gtg VAL V | ||
| 88 | 246 65 gcc ALA A | ||
| 89 | 247 66 acc THR T | ||
| 90 | 248 67 agg ARG R | ||
| 91 | 249 68 att ILEU I | ||
| 92 | 250 69 tgc CYS C | ||
| 93 | 251 70 caa GLN Q | ||
| 94 | --- --- - | ||
| 95 | --- --- - | ||
| 96 | --- --- - | ||
| EF-TURN | 96.1 | --- --- - | |
| 96.2 | --- --- - | ||
| F-STRAND | 97 | 252 71 gga GLY G | |
| 98 | 253 72 gag GLU E | ||
| 99 | 254 73 gag GLU E | ||
| 100 | 255 74 cag GLN Q | ||
| 101 | 256 75 agg ARG R | ||
| 102 | 257 76 ttc PHE F | ||
| 103 | 258 77 acc THR T | ||
| 104 | 259 78 tgc CYS C | ||
| FG-LOOP | 105 | 260 79 tac TYR Y | |
| 106 | 261 80 atg MET M | ||
| 107 | 262 81 gaa GLU E | ||
| 108 | 263 82 cac HIS H | ||
| 109 | 264 83 agc SER S | ||
| 110 | --- --- - | ||
| 111 | --- --- - | ||
| 112 | --- --- - | ||
| 113 | --- --- - | ||
| 114 | 265 84 ggg GLY G | ||
| 115 | 266 85 aat ASN N | ||
| 116 | 267 86 cac HIS H | ||
| 117 | 268 87 agc SER S | ||
| G-STRAND | 118 | 269 88 act THR T | |
| 119 | 270 89 cac HIS H | ||
| 120 | 271 90 cct PRO P | ||
| 121 | 272 91 gtg VAL V | ||
| 122 | 273 92 ccc PRO P | ||
| 123 | 274 93 tct SER S | ||
⇑ Top
Unoccupied positions according to the IMGT unique numbering for G-DOMAIN and G-LIKE-DOMAIN [1] and to the IMGT unique numbering for C-DOMAIN AND C-LIKE-DOMAIN [2] are shown with dashes. The codon encoding the amino acid at position 1 of [D1], [D2] and [D3], according to the IMGT unique numbering, results from the splicing between EX1 and EX2, EX2 and EX3, and EX3 and EX4, respectively. This codon and the nucleotide from the preceding exon are shown between parentheses (see codon_start3 splicing type in IMGT Aide-mémoire, https://www.imgt.org). EMBL/GenBank/DDBJ accession number of MICA*01: AY204547.