with permission from Elsevier| IMGT G-DOMAIN and G-LIKE-DOMAIN labels (1) |
IMGT unique numbering for G-DOMAIN and G-LIKE-DOMAIN (1) |
MHC-Ia (2) | MHC-IIa (2) | MHC-IIb (2) | |||
|---|---|---|---|---|---|---|---|
| I-ALPHA chain | II-ALPHA chain | II-BETA chain | II-ALPHA chain | II-BETA chain | |||
| HLA-A*0201 (3) | HLA-DRA*0101 (3) | HLA-DRB1*1402 (3) | HLA-DMA*01 (3) | HLA-DMB*01 (3) | |||
| G-ALPHA1 [D1] domain | G-ALPHA2 | G-ALPHA [D1] domain | G-BETA [D1] domain | G-ALPHA [D1] domain | G-BETA [D1] domain | ||
| A-STRAND | 1.1 | 1 gct ALA (A) | |||||
| 1.9 | 2 cct PRO P | ||||||
| 1.8 | 3 act THR T | ||||||
| 1.7 | 4 cca PRO P | ||||||
| 1.6 | 5 atg MET M | ||||||
| 1.5 | 6 tgg TRP W | ||||||
| 1.4 | 7 cca PRO P | ||||||
| 1.3 | 8 gat ASP D | ||||||
| 1.2 | 1 atc ILE I | 9 gac ASP D | |||||
| 1.1 | 2 aaa LYS K | 10 ctg LEU L | |||||
| 1 | 1 ggc GLY (G) | 91 ggt GLY (G) | 3 gaa GLU (E) | 1 cca PRO (P) | 11 caa GLN Q | 1 ggt GLY (G) | |
| 2 | 2 tct SER S | 92 tct SER S | 4 gaa GLU E | 2 cgt ARG R | 12 aac ASN N | 2 ggc GLY G | |
| 3 | 3 cac HIS H | 93 cac HIS H | 5 cat HIS H | 3 ttc PHE F | 13 cac HIS H | 3 ttc PHE F | |
| 4 | 4 tcc SER S | 94 acc THR T | 6 gtg VAL V | 4 ttg LEU L | 14 aca THR T | 4 gtg VAL V | |
| 5 | 5 atg MET M | 95 gtc VAL V | 7 atc ILE I | 5 gag GLU E | 15 ttc PHE F | 5 gcc ALA A | |
| 6 | 6 agg ARG R | 96 cag GLN Q | 8 atc ILE I | 6 tac TYR Y | 16 ctg LEU L | 6 cat HIS H | |
| 7 | 7 tat TYR Y | 97 agg ARG R | 9 cag GLN Q | 7 tct SER S | 17 cac HIS H | 7 gtg VAL V | |
| 7A | --- --- - | --- --- - | --- --- - | --- --- - | --- --- - | --- --- - | |
| 8 | 8 ttc PHE F | 98 atg MET M | 10 gcc ALA A | 8 acg THR T | 18 aca THR T | 8 gaa GLU E | |
| 9 | 9 ttc PHE F | 99 tat TYR Y | 11 gag GLU E | 9 tct SER S | 19 gtg VAL V | 9 agc SER S | |
| 10 | 10 aca THR T | 100 ggc GLY G | 12 ttc PHE F | 10 gag GLU E | 20 tac TYR Y | 10 acc THR T | |
| 11 | 11 tcc SER S | 101 tgc CYS C | 13 tat TYR Y | 11 tgt CYS C | 21 tgc CYS C | 11 tgt CYS C | |
| 12 | 12 gtg VAL V | 102 gac ASP D | 14 ctg LEU L | 12 cat HIS H | 22 cag GLN Q | 12 ctg LEU L | |
| 13 | 13 tcc SER S | 103 gtg VAL V | 15 aat ASN N | 13 ttc PHE F | 23 gat ASP D | 13 ttg LEU L | |
| 14 | 14 cgg ARG R | 104 ggg GLY G | 16 cct PRO P | 14 ttc PHE F | 24 ggg GLY G | 14 gat ASP D | |
| AB-TURN | 15 | 15 ccc PRO P | 105 tcg SER S | --- --- - | 15 aat ASN N | --- --- - | 15 gat ASP D |
| 16 | 16 ggc GLY G | 106 gac ASP D | --- --- - | 16 ggg GLY G | --- --- - | 16 gct ALA A | |
| 17 | 17 cgc ARG R | 107 tgg TRP W | --- --- - | 17 acg THR T | --- --- - | 17 ggg GLY G | |
| B-STRAND | 18 | 18 ggg GLY G | 108 cgc ARG R | --- --- - | 18 gag GLU E | --- --- - | 18 act THR T |
| 19 | 19 gag GLU E | 109 ttc PHE F | 17 gac ASP D | 19 cgg ARG R | 25 agt SER S | 19 cca PRO P | |
| 20 | 20 ccc PRO P | 110 ctc LEU L | 18 caa GLN Q | 20 gtg VAL V | 26 ccc PRO P | 20 aag LYS K | |
| 21 | 21 cgc ARG R | 111 cgc ARG R | 19 tca SER S | 21 cgg ARG R | 27 agt SER S | 21 gat ASP D | |
| 22 | 22 ttc PHE F | 112 ggg GLY G | 20 ggc GLY G | 22 ttc PHE F | 28 gtg VAL V | 22 ttc PHE F | |
| 23 | 23 atc ILE I | 113 tac TYR Y | 21 gag GLU E | 23 ctg LEU L | 29 gga GLY G | 23 aca THR T | |
| 24 | 24 gca ALA A | 114 cac HIS H | 22 ttt PHE F | 24 gag GLU E | 30 ctc LEU L | 24 tac TYR Y | |
| 25 | 25 gtg VAL V | 115 cag GLN Q | 23 atg MET M | 25 aga ARG R | 31 tct SER S | 25 tgc CYS C | |
| 26 | 26 ggc GLY G | 116 tac TYR Y | 24 ttt PHE F | 26 tac TYR Y | 32 gag GLU E | 26 atc ILE I | |
| 27 | 27 tac TYR Y | 117 gcc ALA A | 25 gac ASP D | 27 ttc PHE F | 33 gcc ALA A | 27 tcc SER S | |
| 28 | 28 gtg VAL V | 118 tac TYR Y | 26 ttt PHE F | 28 cat HIS H | 34 tac TYR Y | 28 ttc PHE F | |
| BC-TURN | 29 | 29 gac ASP D | 119 gac ASP D | 27 gat ASP D | 29 aac ASN N | 35 gac ASP D | 29 aac ASN N |
| 30 | 30 gac ASP D | 120 ggc GLY G | 28 ggt GLY G | 30 cag GLN Q | 36 gag GLU E | 30 aag LYS K | |
| C-STRAND | 31 | 31 acg THR T | 121 aag LYS K | 29 gat ASP D | 31 gag GLU E | 37 gac ASP D | 31 gat ASP D |
| 32 | 32 cag GLN Q | 122 gat ASP D | 30 gag GLU E | 32 gag GLU E | 38 cag GLN Q | 32 ctg LEU L | |
| 33 | 33 ttc PHE F | 123 tac TYR Y | 31 att ILE I | 33 aac ASN N | 39 ctt LEU L | 33 ctg LEU L | |
| 34 | 34 gtg VAL V | 124 atc ILE I | 32 ttc PHE F | 34 gtg VAL V | 40 ttc PHE F | 34 acc THR T | |
| 35 | 35 cgg ARG R | 125 gcc ALA A | 33 cat HIS H | 35 cgc ARG R | 41 ttc PHE F | 35 tgc CYS C | |
| 36 | 36 ttc PHE F | 126 ctg LEU L | 34 gtg VAL V | 36 ttc PHE F | 42 ttc PHE F | 36 tgg TRP W | |
| 37 | 37 gac ASP D | 127 aaa LYS K | 35 gat ASP D | 37 gac ASP D | 43 gac ASP D | 37 gat ASP D | |
| 38 | 38 agc SER S | 128 gag GLU E | 36 atg MET M | 38 agc SER S | 44 ttt PHE F | 38 cca PRO P | |
| CD-TURN | 39 | 39 gac ASP D | 129 gac ASP D | 37 gca ALA A | 39 gac ASP D | 45 tcc SER S | 39 gag GLU E |
| 40 | 40 gcc ALA A | --- --- - | --- --- - | --- --- - | --- --- - | --- --- - | |
| 41 | 41 gcg ALA A | --- --- - | --- --- - | --- --- - | --- --- - | --- --- - | |
| D-STRAND | 42 | 42 agc SER S | 130 ctg LEU L | 38 aag LYS K | 40 gtg VAL V | 46 cag GLN Q | 40 gag GLU E |
| 43 | 43 cag GLN Q | 131 cgc ARG R | 39 aag LYS K | 41 ggg GLY G | 47 aac ASN N | 41 aat ASN N | |
| 44 | 44 agg ARG R | 132 tct SER S | 40 gag GLU E | 42 gag GLU E | 48 act THR T | 42 aag LYS K | |
| 45 | 45 atg MET M | 133 tgg TRP W | 41 acg THR T | 43 tac TYR Y | 49 cgg ARG R | 43 atg MET M | |
| 46 | 46 gag GLU E | 134 acc THR T | 42 gtc VAL V | 44 cgg ARG R | 50 gtg VAL V | 44 gcc ALA A | |
| 47 | 47 ccg PRO P | 135 gcg ALA A | 43 tgg TRP W | 45 gcg ALA A | 51 cct PRO P | 45 cct PRO P | |
| 48 | 48 cgg ARG R | 136 gcg ALA A | 44 cgg ARG R | 46 gtg VAL V | 52 cgc ARG R | 46 tgc CYS C | |
| 49 | 49 gcg ALA A | 137 gac ASP D | 45 ctt LEU L | 47 acg THR T | 53 ctg LEU L | 47 gaa GLU E | |
| 49.1 | --- --- - | --- --- - | --- --- - | --- --- - | --- --- - | 48 ttt PHE F | |
| 49.2 | --- --- - | --- --- - | --- --- - | --- --- - | --- --- - | 49 ggg GLY G | |
| 49.3 | --- --- - | --- --- - | --- --- - | --- --- - | --- --- - | 50 gtg VAL V | |
| 49.4 | --- --- - | --- --- - | --- --- - | --- --- - | --- --- - | 51 ctg LEU L | |
| 49.5 | --- --- - | --- --- - | --- --- - | --- --- - | --- --- - | --- --- - | |
| HELIX | 50 | 50 ccg PRO P | 138 atg MET M | 46 gaa GLU E | 48 gag GLU E | 54 ccc PRO P | 52 aat ASN N |
| 51 | 51 tgg TRP W | 139 gca ALA A | 47 gaa GLU E | 49 ctg LEU L | 55 gaa GLU E | 53 agc SER S | |
| 52 | 52 ata ILE I | 140 gct ALA A | 48 ttt PHE F | 50 ggg GLY G | 56 ttt PHE F | 54 ttg LEU L | |
| 53 | 53 gag GLU E | 141 cag GLN Q | 49 gga GLY G | 51 cgg ARG R | 57 gct ALA A | 55 gcg ALA A | |
| 54 | 54 cag GLN Q | 142 acc THR T | 50 cga ARG R | 52 cct PRO P | 58 gac ASP D | 56 aat ASN N | |
| 54A | --- --- - | --- --- - | --- --- - | --- --- - | --- --- - | --- --- - | |
| 55 | 55 gag GLU E | 143 acc THR T | --- --- - | 53 gat ASP D | --- --- - | 57 gtc VAL V | |
| 56 | 56 ggt GLY G | 144 aag LYS K | --- --- - | 54 gcc ALA A | --- --- - | 58 ctc LEU L | |
| 57 | 57 ccg PRO P | 145 cac HIS H | --- --- - | 55 gag GLU E | --- --- - | 59 tca SER S | |
| 58 | 58 gag GLU E | 146 aag LYS K | --- --- - | 56 tac TYR Y | --- --- - | 60 cag GLN Q | |
| 59 | 59 tat TYR Y | 147 tgg TRP W | 51 ttt PHE F | 57 tgg TRP W | 59 tgg TRP W | 61 cac HIS H | |
| 60 | 60 tgg TRP W | 148 gag GLU E | 52 gcc ALA A | 58 aac ASN N | 60 gct ALA A | 62 ctc LEU L | |
| 61 | 61 gac ASP D | 149 gcg ALA A | 53 agc SER S | 59 agc SER S | 61 cag GLN Q | 63 aac ASN N | |
| 61A | --- --- - | 150 gcc ALA A | --- --- - | 60 cag GLN Q | 62 gaa GLU E | 64 caa GLN Q | |
| 61B | --- --- - | --- --- - | --- --- - | 61 aag LYS K | 63 cag GLN Q | 65 aaa LYS K | |
| 62 | 62 ggg GLY G | 151 cat HIS H | 54 ttt PHE F | 62 gac ASP D | 64 gga GLY G | 66 gac ASP D | |
| 63 | 63 gag GLU E | 152 gtg VAL V | 55 gag GLU E | 63 ctc LEU L | 65 gat ASP D | 67 acc THR T | |
| 64 | 64 aca THR T | 153 gcg ALA A | 56 gct ALA A | 64 ctg LEU L | 66 gct ALA A | 68 ctg LEU L | |
| 65 | 65 cgg ARG R | 154 gag GLU E | 57 caa GLN Q | 65 gag GLU E | 67 cct PRO P | 69 atg MET M | |
| 66 | 66 aaa LYS K | 155 cag GLN Q | 58 ggt GLY G | 66 cag GLN Q | 68 gcc ALA A | 70 cag GLN Q | |
| 67 | 67 gtg VAL V | 156 ttg LEU L | 59 gca ALA A | 67 agg ARG R | 69 att ILE I | 71 cgc ARG R | |
| 68 | 68 aag LYS K | 157 aga ARG R | 60 ttg LEU L | 68 cgg ARG R | 70 tta LEU L | 72 ttg LEU L | |
| 69 | 69 gcc ALA A | 158 gcc ALA A | 61 gcc ALA A | 69 gcc ALA A | 71 ttt PHE F | 73 cgc ARG R | |
| 70 | 70 cac HIS H | 159 tac TYR Y | 62 aac ASN N | 70 gcg ALA A | 72 gac ASP D | 74 aat ASN N | |
| 71 | 71 tca SER S | 160 ctg LEU L | 63 ata ILE I | 71 gtg VAL V | 73 aaa LYS K | 75 ggg GLY G | |
| 72 | 72 cag GLN Q | 161 gag GLU E | 64 gct ALA A | 72 gac ASP D | 74 gag GLU E | 76 ctt LEU L | |
| 72A | --- --- - | 162 ggc GLY G | --- --- - | 73 acc THR T | --- --- - | 77 cag GLN Q | |
| 73 | 73 act THR T | 163 acg THR T | 65 gtg VAL V | 74 tac TYR Y | 75 ttc PHE F | 78 aat ASN N | |
| 74 | 74 cac HIS H | 164 tgc CYS C | 66 gac ASP D | 75 tgc CYS C | 76 tgc CYS C | 79 tgt CYS C | |
| 75 | 75 cga ARG R | 165 gtg VAL V | 67 aaa LYS K | 76 aga ARG R | 77 gag GLU E | 80 gcc ALA A | |
| 76 | 76 gtg VAL V | 166 gag GLU E | 68 gcc ALA A | 77 cac HIS H | 78 tgg TRP W | 81 aca THR T | |
| 77 | 77 gac ASP D | 167 tgg TRP W | 69 aac ASN N | 78 aac ASN N | 79 atg MET M | 82 cac HIS H | |
| 78 | 78 ctg LEU L | 168 ctc LEU L | 70 ctg LEU L | 79 tac TYR Y | 80 atc ILE I | 83 acc THR T | |
| 79 | 79 ggg GLY G | 169 cgc ARG R | 71 gaa GLU E | 80 ggg GLY G | 81 cag GLN Q | 84 cag GLN Q | |
| 80 | 80 acc THR T | 170 aga ARG R | 72 atc ILE I | 81 gtt VAL V | 82 caa GLN Q | 85 ccc PRO P | |
| 81 | 81 ctg LEU L | 171 tac TYR Y | 73 atg MET M | 82 ggt GLY G | 83 ata ILE I | 86 ttc PHE F | |
| 82 | 82 cgc ARG R | 172 ctg LEU L | 74 aca THR T | 83 gag GLU E | 84 ggg GLY G | 87 tgg TRP W | |
| 83 | 83 ggc GLY G | 173 gag GLU E | 75 aag LYS K | 84 agc SER S | 85 cca PRO P | 88 gga GLY G | |
| 84 | 84 tac TYR Y | 174 aac ASN N | 76 cgc ARG R | 85 ttc PHE F | 86 aaa LYS K | 89 tca SER S | |
| 85 | 85 tac TYR Y | 175 ggg GLY G | 77 tcc SER S | 86 aca THR T | 87 ctt LEU L | 90 ctg LEU L | |
| 86 | 86 aac ASN N | 176 aag LYS K | 78 aac ASN N | 87 gtg VAL V | 88 gat ASP D | 91 acc THR T | |
| 87 | 87 cag GLN Q | 177 gag GLU E | 79 tat TYR Y | 88 cag GLN Q | 89 ggg GLY G | 92 aac ASN N | |
| 88 | 88 agc SER S | 178 acg THR T | 80 act THR T | 89 cgg ARG R | 90 aaa LYS K | 93 agg ARG R | |
| 89 | 89 gag GLU E | 179 ctg LEU L | 81 ccg PRO P | 90 cga ARG R | 91 atc ILE I | 94 aca THR T | |
| 90 | 90 gcc ALA A | 180 cag GLN Q | 82 atc ILE I | --- --- - | 92 ccg PRO P | --- --- - | |
| 91 | --- --- - | 181 cgc ARG R | 83 acc THR T | --- --- - | 93 gtg VAL V | --- --- - | |
| 92 | --- --- - | 182 acg THR T | 84 aat ASN N | --- --- - | 94 tcc SER S | --- --- - | |
| 92A | --- --- - | --- --- - | --- --- - | --- --- - | 95 aga ARG R | --- --- - | |