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Alzheimer disease

Deposition of amyloid β (αβ) peptides within extracellular plaques in the brains of Alzheimer's Disease (AD) patients occurs following amyloid precursor protein (APP) cleavage by various proteases. The three proteases involved in processing APP include: α-,β- and γ-secretase. APP is cleaved at the N-terminus after Met 671 by β-secretase. The membrane-retained C-terminal fragment can then be further cleaved by γ-secretase within the hydrophobic transmembrane domain, thus releasing αβ.