The activities of NF-κB proteins are controlled by members of the IκB family of inhibitor proteins:
| IKBA | IκB-α |
| IKBB | IκB-β |
| NFKB1 | IκB-γ/p105/NF-κB1 |
| NFKB2 | IκB-δ/p100/NF-κB2 |
| IKBE | IκB-ε |
| BCL3 | Bcl-3 |
all of which contain five to seven ankyrin-repeats serving as binding interfaces [1].