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SHP-1, Tyrosine phosphatase

The tyrosine phosphatase SHP-1 associates with ITIM and negatively regulates BcR signalling.

SHP-1 is also expressed in thymocytes. Results obtained with mice either lacking SHP-1, as in the mutant strain motheater, or in mice overexpressing a dominant-negative form of the protein suggest that SHP-1 can function to negatively regulate signaling by the TcR and influence thymocyte selection.