IMGT Lexique

Siglec

Sialic acid-binding immunogobulin superfamily lectins. IgSF members that recognize sialic acids.

Siglec-1 (sialoadhesin) [macrophages] human recognizes α2-3 linked Neu5Ac (NANA) residues on glycolipids and glycoproteins:
NeuAc(NANA) α2-3galβ1-3galNAc
NeuAc(NANA) α2-3galβ1-3gacNAc
Siglec-2 (CD22) [B cells] recognizes α2-6 linked sialic acids
Siglec-3 (CD33) [mycloid cells] binds both α2-3 and α2-6 linked sialic acids
Siglec-5 [neutrophils] recognizes α2-3, α2-6 and α2-8 linked sialic acids
Siglec-6 (OB_BP1) [B cells, placental trophoblasts] recognizes sialy-Tn