IMGT Lexique

Tec Family Kinases

Tec Family Kinases
Protein	Protein size (kDa)	Tissue expression	Cell lineage expression	Chromosomal localization	Activating pathway	Phenotype of single mutation
Tec29/dsrc29A/Dsrc29c	66/55*	embryo, oocyte, imaginal disc		polytene chromosome 28c	unknown	embryonic lethality and defective oogenesis
Bmx/Etk	80	bone marrow, lung, testis, colon, heart	macrophage neutrophil	Xp22.2 (human) ? (mouse)	IL-6R Gα12/13	unknown

Btk /Bpk/Atk/Emb	77	bone marrow, spleen, lymph node, fetal liver	B, myeloid, erythroid, mast, megakaryocyte	Xq22 (human) syntenic Xq22 (mouse)	BcR, FcΕRI, gp130 (IL-6R), IL-5R, IL-10R, CD19, CD28 CD38, CD40	block in B cell development, defective BcR signaling and XLA, defective degranulation
Itk/Tsk/Emt	72	thymus, spleen, lymph node	T, NK, mast cells	5q31-32 (human) ? (mouse)	TcR, CD28, CD2, FCΕRI	reduction in CD4⁺subset and defect in TcR signalling
Rlk/Txk	52/58*	thymus, spleen, lymph node, tonsil, testis	T, myeloid	4p12 (human) chromosome 5 (mouse)	TcR	subtle, some reduction of IL-2 production

Tec	72/70/66/58*	bone marrow, spleen, thymus	T, B, myeloid, hepatocarcinoma	4p12 (human) chromosome 5 (mouse)	TcR, CD28, BcR, CD38, gp130, (IL-3R, IL-6R), EpoR, G-CSFR, TpoR, c kit,	unknown

* Alternative splicing site of mRNA or alternative start site yields multiple isoforms.