IMGT Lexique

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Topoisomerase I inhibitors

Topoisomerase I inhibitors include:

Camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata.

Camptothecin derivatives which comprise :

irinotecan (CPT-11)
10-hydroxy-7-ethylcamptothecin (SN-38), the active metabolite of irinotecan
topotecan
DX-8951f (exatecan mesylate), an hexacyclic camptothecin analog