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Spacefill 3D representation of an IgG immunoglobulin

VH corresponds to the V-D-J-REGION (in green (V), orange (DJ)) of the heavy chain.
VL corresponds to the V-J-REGION (in green (V) and yellow (J)) of the light chain.
Click here for a Schematic representation of an immunoglobulin.

The corresponding PDB (Protein Data Bank) format file is from Mike's immunoglobulin structure function site (http://www.umass.edu/microbio/rasmol/padlan.htm).

The first chrystal 3D structure of a complete immunoglobulin is that of B12, a human IgG1, anti-HIV1, determined in 2001 (PDB code: 1hzh in IMGT/3Dstructure-DB).

This IgG1 model is described in Fig. 1 in Anatomy of the Antibody Molecule by Eduardo A. Padlan, Mol. Immunol. 31:169-217, 1994.
It is a composite model of a F(ab')2 built from the Fab from 2ig2 and an Fc fragment from 1fc2. Part of the hinge region and other details are theoretically modeled.

Created: 28/06/2001
Last updated: Friday, 22-Sep-2023 18:15:58 CEST
Author: Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr
Editors: Elodie Foulquier, Chantal Ginestoux