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Adhesion molecules

Selectins

Selectins CD HGNC gene name Alias Entrez Gene Swiss-Prot OMIM Ligands Ligand distribution Fonction
Hematopoietic cells
Platelets
Neural cells Endothelium
Epithelium
L-selectin CD62L SELL LSEL 6402 P14151 153240 Sulfated: GlyCAM-1
CD34
MAdCAM-1
Leucocytes (Homing receptor)
E-selectin CD62E SELE ESEL 6401 P16581 131210 Tetrasaccharides: Sialyl-Lewisx
Sialyl-Lewisa
Cutaneous lymphocyte-associated antigen
Endothelium
P-selectin CD62P SELP PSEL 6403 P16109 173610 Tetrasaccharides: Sialyl-Lewisx
P-selectin glycoprotein ligand-1
Platelets Endothelium

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Neu-IgCAMs

Neural specific cell adhesion molecules belonging to the IgSF.
Neu-IgCAM CD HGNC gene name Alias Entrez Gene Swiss-Prot OMIM Ligands Ligand distribution Fonction
Hematopoietic
Thymocyte
Neural cells Endothelial
Epithelium
Adhesion molecule on glia (AMOG) ATP1B2 482 P14415 182331 Glial Neural migration
L1CAM CD171 L1CAM 3897 P32004 308840 Axonin Neural
Myelin-associated glycoprotein
(MAG)
MAG 4099 P20916 159460 MAG Myelin
Myelin-oligodendrocyte glycoprotein
(MOG)
MOG 4340 Q16653 159465 Myelin Oligodendrocytes
NCAM-1 CD56 NCAM1 4684 P13591 116930 NCAM-1 via polysialic acid
Modulated by Sialyltransferase X
Polysialyltransferase
Neural
NrCAM NRCAM 4897 Q92823 601581 Neural
Neurofascin NFASC 23114 O94856 609145
NgCAM (neural-glial CAM) L1
OBCAM OPCML OPCM 4978 Q14982 600632 Opioids (μ)
Acidic lipids
Brain
P0 MPZ 4359 P25189 159440 P0 Myelin
PMP-22 PMP22 5376 Q01453 601097 PMP-22 Myelin
SynCAM IGSF4 23705 Q8N2F4 605686 Neural
Synapse

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Leu-IgCAMs

Systemic cell adhension molecules belonging to the IGSF, mostly on Leucocytes.
Leu-IgCAM CD HGNC gene name Alias Entrez Gene Swiss-Prot OMIM Ligands Ligand distribution Fonction Disease
Hematopoietic
Thymocyte
Neural cells Endothelial
Epithelium
ALCAM CD166 ALCAM 214 Q13740 601662 CD6, CD166
NgCAM
35 kD protein
Leukocytes Neural
Basigin CD147 BSG 682 P35613 109480 Leukocytes
RBCs
Platelets
Endothelial
BL-CAM CD22 CD22 933 P20273 107266 Sialylated glycoproteins
LCA (CD45)
B-Lymphocytes
CD44 CD44 CD44 960 P16070 107269 Hyaluronin
Ankyrin
Fibronectin
MIP1β
Osteopontin
Lymphocytes WM perivascular astrocytes
Glial tumors (malignant)
Metastases (CD44v splice variant)
Epithelial
ICAM-1 CD54 ICAM1 3383 P05362 147840 αLβ2
LFA-1
Leukocytes
Dendritic cells
Fibroblasts
Synovial cells
Endothelial cells
Epithelium
Disease: Lys29Met mutation
Susceptibility to cerebral malaria
ICAM-2 CD102 ICAM2 3384 P13598 146630 αL/β2 (LFA-1) Lymphocytes
Monocytes
Endothelial cells
ICAM-3 CD50 ICAM3 3385 P32942 146631 αLβ2 Leukocytes
Lymphocyte function antigen-2
(LFA-2)
CD2 CD2 914 P06729 186990 LFA-3 Lymphocytes
Thymocytes
LFA-3 CD58 CD58 965 P19256 153420 LFA-2 Leukocytes Astrocytoma Stroma Endothelial cells
Major histocompatibility complex
(MHC) molecules
MADCAM-1 MADCAM1 MACAM1 8174 Q13477 102670 α4β7
L-selectin
Mucosal endothelial cells
PECAM CD31 PECAM1 5175 P16284 173445 CD31
αv β3
Leukocytes Synovial cells Endothelial cells
T-cell receptor
(C-region)
TRAC 28755
VCAM-1 CD106 VCAM1 7412 P19320 192225 α4β1
α4β7
Monocytes Satellite cells
Synovial cells
Activated endothelial cells

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Created:
01/02/2007
Authors:
Yan Wu and Marie-Paule Lefranc
Editor:
Chantal Ginestoux