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Table of integrins

Integrins are heterodimers formed by two subunits, an alpha chain and a beta chain. There are 17 INTEGRIN-ALPHA chains and 8 INTEGRIN-BETA chains. The association of an INTEGRIN-ALPHA chain and an INTEGRIN-BETA chain leads to 25 different integrins.

Integrins

INTEGRIN-ALPHA chains are shown vertically and INTEGRIN-BETA chains are shown horizontally.
Integrins are indicated at the intersection of vertical and horizontal lines.
In IMGT/3Dstructure-DB, integrins are described according to IMGT-ONTOLOGY.
For example : INTEGRIN-ALPHA1_BETA-1 for α1β1.

INTEGRIN - BETA-1 BETA-2 BETA-3 BETA-4 BETA-5 BETA-6 BETA-7 BETA-8
ALPHA-1 ALPHA-1_BETA-1
α1β1 or VLA1
Laminin and collagen receptor
ALPHA-2 ALPHA-2_BETA-1
α2β1 or VLA2,
Collagen receptor
ALPHA-3 ALPHA-3_BETA-1
α3β1 or VLA3
ALPHA-4 ALPHA-4_BETA-1
α4β1 or VLA4,
VCAM1 receptor
ALPHA-4_BETA-7
α4β7
ALPHA-5 ALPHA-5_BETA-1
α5β1 or VLA5,
Fibronectin receptor
ALPHA-5_BETA-5
α5β5
ALPHA-5_BETA-6
α5β6
ALPHA-V ALPHA-V_BETA-1
αVβ1
ALPHA-V_BETA-3
αvβ3 or CD51/CD61
VNR (Vitronectin receptor)
ALPHA-V_BETA-5
αVβ5
ALPHA-V_BETA-6
αVβ6
ALPHA-V_BETA-8
αVβ8
ALPHA-6 ALPHA-6_BETA-1
α6β1 or VLA6,
Laminin receptor
ALPHA-6_BETA-4
α6β4
ALPHA-7 ALPHA-7_BETA-1
α7β1
ALPHA-8 ALPHA-8_BETA-1
α8β1
ALPHA-9 ALPHA-9_BETA-1
α9β1
ALPHA-D ALPHA-D_BETA-2
αdβ2
ALPHA-L ALPHA-L_BETA-2
αLβ2, LFA1 or CD11a/CD18,
ICAM1, ICAM2 and ICAM3 receptor
ALPHA-M ALPHA-M_BETA-2
αMβ2, CD11b/CD18, Mac1,
CR3 (iC3b receptor 3)
ALPHA-X ALPHA-X_BETA-2
αXβ2, CD11c/CD18, P150,95
CR4 (iC3b receptor 4)
ALPHA-E ALPHA-E_BETA-7
αEβ7
ALPHA-IIb ALPHA-IIb_BETA-3
αIIbβ3 or GPIIbIIIa
or CD41/CD61,
Fibrinogen receptor
ALPHA-R ALPHA-R_BETA-3
αRβ3

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Integrin chains

IMGT chain description Chain CD HGNC gene name Alias Chromosome Entrez Gene Swiss-Prot OMIM (for gene) Receptor to which the chain belongs Disease OMIM (for disease)
INTEGRIN-ALPHA-1 α1 CD49a ITGA1 5q11.1 3672 P56199 192968
INTEGRIN-ALPHA-2 α2 CD49b ITGA2 GPIa 5q23-31 3673 P17301 192974 Collagen receptor GPIa/IIa
α2β1
INTEGRIN-ALPHA-3 α3 CD49c ITGA3 17q21.33 3675 P26006 605025
INTEGRIN-ALPHA-4 α4 CD49d ITGA4 2q31-q32 3676 P13612 192975
INTEGRIN-ALPHA-5 α5 CD49e ITGA5 12q11-q13 3678 P08648 135620 Myopathy in Chimeric mouse
INTEGRIN-ALPHA-V αV CD51 ITGAV 2q31-q32 3685 P06756 193210
INTEGRIN-ALPHA-6 α6 CD49f ITGA6 GPI 2 3655 P23229 147556 Junctional epidermolysis bullosa
INTEGRIN-ALPHA-7 α7 ITGA7 12q13 3679 Q13683 600536 Congenital MD Knockout -> Myopathy
INTEGRIN-ALPHA-8 α8 ITGA8 10p13 8516 P53708 604063
INTEGRIN-ALPHA-9 α9 ITGA9 3p21.3 3680 Q13797 603963
INTEGRIN-ALPHA-D αD CD11d ITGAD 16p13.1-p11 3681 Q13349 602453
INTEGRIN-ALPHA-L αL CD11a ITGAL 16p13.1-p11 3683 P20710 153370
INTEGRIN-ALPHA-M αM CD11b ITGAM 16p11.2 3684 P11215 120980
INTEGRIN-ALPHA-X αX CD11c ITGAX 16p11.2 3687 P20702 151510
INTEGRIN-ALPHA-E αE CD103 ITGAE αIEL 17p13 3682 P38570 604682
INTEGRIN-ALPHA-IIB αIIβ CD41 ITGA2B GPIIb 17q21.32 3674 P08514 607759 Fibrinogen receptor GPIIb/IIIa
αIIbβ3
INTEGRIN-ALPHA-R αR
INTEGRIN-BETA-1 β1 CD29 ITGB1 GPIIa 10p11.2 3688 P05556 135630 Collagen receptor GPIa/IIa
α2β1
INTEGRIN-BETA-2 β2 CD18 ITGB2 21q22,3 3689 P05107 600065 Leukocyte adhesion deficiency (LAD)
(LFA-A immunodeficiency)
*116920
INTEGRIN-BETA-3 β3 CD61 ITGB3 GPIIIa 17q21,32 3690 P05106 173470 Fibrinogen receptor GPIIb/IIIa
αIIbβ3
Glanzmann thrombasthenia (GT), Type B *273800
INTEGRIN-BETA-4 β4 CD104 ITGB4 17q11 3691 P16144 147577 Junctional epidermolysis bullosa *131800
INTEGRIN-BETA-5 β5 ITGB5 3q21.2 3693 P18084 147561
INTEGRIN-BETA-6 β6 ITGB6 2 3694 P18564 147558
INTEGRIN-BETA-7 β7 ITGB7 12q13.1 3695 P26010 147559
INTEGRIN-BETA-8 β8 ITGB8 7p15.3 3696 P26012 604160

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Integrins and Ligands

IMGT Receptor description
Integrins
Ligands Ligand distribution Fonction
Hematopoietic cells
Platelets, Thymocytes
Neural cells Endothelium
Epithelium
Fibroblasts
INTEGRIN_ALPHA-1_BETA-1
α1β1
Laminin
Collagen
Tenascin
NK, B and T activated Glial
Perineurium
Schwann cells
Endothelium
Fibroblasts
INTEGRIN_ALPHA-2_BETA-1
α2β1
Laminin
Collagen
NK, B and T activated
Platelets
Astrocytes
Ependymal
Schwann cells
Endothelium
Epithelium
Fibroblasts
INTEGRIN_ALPHA-3_BETA-1
α3β1
Laminin
Collagen
Fibronectin
T activated
Thymocytes
Astrocytes Endothelium
Epithelium
Fibroblasts
INTEGRIN_ALPHA-4_BETA-1
α4β1
α4β1
α4β7
Fibronectin
VCAM-1
MAdCAM-1
TSP-1
NK, B and T
Eosinophils
Neural-crest derived Endothelium
Fibroblasts
Muscle
T cell TransEndothelium migration
INTEGRIN_ALPHA-5_BETA-1
α5β1
Fibronectin
murine L1
B activated and T activated
memory T cells
Thymocytes
Platelets
Astrocytes Endothelium
Epithelium
Fibroblasts
INTEGRIN_ALPHA-6_BETA-1
α6β1
Laminin T cells (Memory and activated)
Leucocytes
Thymocytes
Glial Endothelium
Epithelium
Fibroblasts
INTEGRIN_ALPHA-7_BETA-1
α7β1
Laminin Melanoma
Skeletal and cardiac muscle
INTEGRIN_ALPHA-8_BETA-1
α8β1
(CD-/CD29
VLA-8)
Fibronectin
Vitronectin
Tenascin
Neurons
Oligodendroglia
Epithelium
INTEGRIN_ALPHA-9_BETA-1
α9β1
Epithelium (airway)
Muscle
INTEGRIN_ALPHA-V_BETA-1
αvβ1
Vitronectin
Fibronectin
Collagen
von Willebrand factor
Fibrinogen
Oligodendroglia
INTEGRIN_ALPHA-L_BETA-2
αLβ2
(LFA-1α
CD11a)
ICAM-1
ICAM-2
ICAM-3
T cells
Leucocytes
Thymocytes
Macrophages
Microglia
INTEGRIN_ALPHA-M_BETA-2
αMβ2
(CD11b)
ICAM-1
Factor X
iC3b
Fibrinogen
NK
B activated
Myeloid
Macrophages
B leukemic cells
Microglia
INTEGRIN_ALPHA-X_BETA-2
αXβ2
(CD11c)
iC3b
Fibrinogen
B activated
Myeloid
Macrophages
Dendritic cells
B leukemic cells
Microglia
INTEGRIN_ALPHA-IIb_BETA-3
αIIbβ3
Fibronectin
Vitronectin
von Willebrand's factor
Thrombospondin
Platelets
INTEGRIN_ALPHA-V_BETA-3
αvβ3
(CD51/CD61)
Fibronectin
Osteopontin
von Willebrand's factor
PE-CAM-1
Vitronectin
Fibrinogen
human L1
Thrombospondin
Collagen
B activated
T activated
Monocytes
Glia
Schwann cells
Endothelium
Tumors
INTEGRIN_ALPHA-6_BETA-4
α6β4
Laminin Not in immune cells Schwann cells
Perineurium
Endothelium
Epithelium
Fibroblasts
INTEGRIN_ALPHA-V_BETA-5
αvβ5
(CD51/CD-)
Vitronectin
Fibronectin
Fibrinogen
Monocytes
Macrophages
Oliogodendroglia Epithelium
Fibroblasts
Tumors
INTEGRIN_ALPHA-V_BETA-6
αvβ6
Fibronectin
INTEGRIN_ALPHA-V_BETA-8
αvβ8
Fibronectin Brain synapses
Oligodendroglia
Schwann cells
INTEGRIN_ALPHA-4_BETA-7
α4β7
Fibronectin
VCAM-1
MAdCAM-1
NK, B & T cells Not in neural cells
INTEGRIN_ALPHA-IEL_BETA-7
αIELβ7
(CD103)
E-cadherin Intraepithelial T lymphocytes (IEL) (Intestinal)
INTEGRIN_ALPHA-11
α11
Uterus, Heart, Skeletal muscle, Smooth muscle

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Integrins and Diseases

INTEGRIN- Disease OMIM (for disease)
ALPHA-1
ALPHA-2
ALPHA-3
ALPHA-4
ALPHA-5 Myopathy in Chimeric mouse
ALPHA-V
ALPHA-6 Junctional epidermolysis bullosa
ALPHA-7 Congenital MD Knockout -> Myopathy
ALPHA-8
ALPHA-9
ALPHA-D
ALPHA-L
ALPHA-M
ALPHA-X
ALPHA-E
ALPHA-IIB
ALPHA-R
BETA-1
BETA-2 Leukocyte adhesion deficiency (LAD)
(LFA-A immunodeficiency)
*116920
BETA-3 Glanzmann thrombasthenia (GT), Type B *273800
BETA-4 Junctional epidermolysis bullosa *131800
BETA-5
BETA-6
BETA-7
BETA-8

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* : Disorder caused by mutations in different genes.


Created:
01/02/2007
Authors:
Yan Wu and Marie-Paule Lefranc
Editor:
Chantal Ginestoux