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Structural and biological properties of human immunoglobulins


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Link to paper

Tableau 2

Human and mouse IG classes and subclasses

Human IG classes and subclasses
Disulfide bridges Chain Classes and subclasses
IgM IgD IgG IgA IgE
IgG1 IgG2 IgG3 IgG4 IgA1 IgA2
Inter H-L H (1) Number 1 1 1 1 1 1 1 1 1?
Positions CH1: 10 CH1: 11 H: 5 CH1: 10 CH1: 10 CH1: 10 CH1: 10 CH1: 123 CH1: 10, 11
L (2) C-KAPPA 126 (last residue)
C-LAMBDA 126 (last-but-one residue)
Inter H-H H (1) Number 1 1 2 4 11 2 2? 2? 1?
Positions CH2: 125 CH2: 1.6 H: 11, 14 H: 4, 5, 8, 11 H1: 13, 16
H2: 5, 11, 14
H3: 5, 11, 14
H4: 5, 11, 14
H: 8, 11 CH2: 1.1, 1.2 CH2: 1.1, 1.2 CH2: 1.6, 11, 124

Mouse IG classes and subclasses
Disulfide bridges Chain Classes and subclasses
IgM IgD IgG IgA IgE
IgG1 IgG2A IgG2B IgG2C IgG3
Inter H-L H (1) Number 1 1 1 1 1 1 1 1? 1
Positions CH1: 10 CH1: 10 H: 5 CH1: 11 CH1: 11 CH1: 11 CH1: 11 CH1: 123
CH2: 1.1
CH1: 10
L(2) C-KAPPA 126 (last residue)
C-LAMBDA 126 (last-but-one residue)
Putative inter H-H H (1) Number 1 0 3 3 4 3 1 ? 2
Positions CH2: 125 no H-H bridge H:7, 10, 12 H: 10, 13, 15 H: 12, 15, 18, 21 H: 11, 17, 20 H: 15 ? CH2: 11, 124
Notes:
(1) H: heavy chain
(2) L: light chain (kappa or lambda)
Created:
11/12/2012
Last updated:
20/01/2020
Authors:
Souphatta Sasorith and Marie-Paule Lefranc
Editor:
Chantal Ginestoux