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IMGT-ONTOLOGY


List of figures
Figure6

Figure 6. Identification of an IG or antibody as an instance of the "Molecule_ReceptorType" concept made of four chains, two IG-Heavy-Chain and two IG-Light-Chain ("ChainType" concept)

The four representations, although different, allow to identify an IG as a receptor of four chains, themselves organized in domains ("DomainType" concept). VH and VL are V type domains, coded by the V-D-J region and V-J region, respectively. CL, CH1, CH2 and CH3 are C type domains.
(A) 3D structure,
(B) organization in Ig-like domains,
(C) organization in modules,
(D) regions coded by the V, D, J and C gene types.
The C gene type codes the constant region (CL for the IG-Light-Chain and CH1, hinge, CH2 and CH3 for the IG-Heavy-Chain). This representation, schematized as a Y shape, is frequently used to represent an IG.

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Created:
18/07/2007
Last updated:
22/09/2023
Authors:
Véronique Giudicelli and Marie-Paule Lefranc
Editor:
Chantal Ginestoux