Specificity
The specificity is the selective reactivity of an antibody for a native antigen or that of a T cell receptor for a peptide-MHC complex.
The 'specificity' concept identifies the nature of these antigens recognized by the immunoglobulins or T cell receptors. The specificity is defined for rearranged IG and TR sequences.
The definition of the specificities has been standardized to facilitate queries.
Click here for a List of the specificities available in IMGT/LIGM-DB.
Specificity can be queried from the "Taxonomy,..." module in IMGT/LIGM-DB.
The 'specificity' concept is part of the 'IDENTIFICATION' concept of IMGT-ONTOLOGY [1].
Specificity description
The specificity is described by the prefix "anti-" followed by the antigen name, or by the peptide-MHC complex designation.
- Between parentheses is indicated additional information (comment or synonym) about the antigen.
- Between brackets is shown the source and/or origin of the antigen recognized by the antibody (species, tissue, etc.).
- Double specificities are shown separated by a comma.
For anti-idiotype, the antigen recognized by the isotype is shown separated by the sign ">".
Allelic forms of a ligand are shown by an asterisk followed by the polymorphic amino acid (single letter abbreviation) and its position.
