Only FUNCTIONAL and ORF V-GENEs are shown.
IGHV
genes |
FR1-IMGT 1 to 26 |
CDR1-IMGT 27 to 38 |
FR2-IMGT 39 to 55 |
CDR2-IMGT 56 to 65 |
FR3-IMGT 66 to 104 |
CDR3-IMGT
(germline V-GENE) 105 to 115 |
(25) | (6 to 9) | (17) | (5 to 10) | (37,38) | (2) (1) | |
IGHV1S1 IGHV1S2 IGHV1S3 IGHV1S4 IGHV1S5 IGHV1S6 IGHV1S7 IGHV1S8 IGHV1S9 IGHV1S10 IGHV1S11 IGHV1S12 IGHV1S13 IGHV1S14 IGHV1S15 IGHV1S16 IGHV1S17 IGHV1S18 IGHV1S19 IGHV1S20 |
-1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) |
8 8 8 8 8 8 8 8 8 8 8 8 8 7 8 8 8 8 n.d. n.d. |
7 8 9 10 9 10 9 9 10 8 9 9 9 9 8 8 7 9 8 n.d. |
-1 (aa 73) -1 (aa 73) -1 (aa 73) -1 (aa 73) -1 (aa 73) -1 (aa 73) -1 (aa 73) -1 (aa 73) -1 (aa 73) -1 (aa 73) -1 (aa 73) -1 (aa 73) -2 (aa 73,81) -2 (aa 73,81) -1 (aa 73) -1 (aa 73) -1 (aa 73) -1 (aa 73) -1 (aa 73) |
2 (1) | |
IGHV2S1 IGHV2S2 IGHV2S3 IGHV2S4 |
-1 (aa 10) -1 (aa 10) |
8 9 8 n.d. |
6 8 8 8 |
-1 (aa 73) | 2 (1) | |
IGHV3S1 IGHV3S2 IGHV3S3 IGHV3S4 IGHV3S5 |
-1 (aa 10) | 7 7 7 6 6 |
7 6 6 7 5 |
-1 (aa 73) | 2 (1) |
The proteolytic cleavage site between the leader peptide and the V-REGION is putative and the assignment of amino acid 1 to one or the other region is uncertain.
IMGT note:
(1) | Probable CDR3-IMGT length but needs to be confirmed with germline sequences. |
Created: 08/09/1999
Last updated: Friday, 22-Sep-2023 18:17:38 CEST
Authors: Sylvaine Artero and Nathalie Bosc