Only FUNCTIONAL and ORF V-GENEs are shown.
IGHV subgroup | FR1-IMGT 1 to 26 | CDR1-IMGT 27 to 38 | FR2-IMGT 39 to 55 | CDR2-IMGT 56 to 65 | FR3-IMGT 66 to 104 | CDR3-IMGT (germline V-GENE) 105 to 115 |
(25) | (8,10) | (17) | (7 to 11) | (36 to 38) | (2)(2) | |
IGHV1 | -1 (aa 10) | 8 | 8 | -1 (aa 73) | 2 | |
IGHV2 | -1 (aa 10) | 8 | 10 | -1 (aa 73) | 2 | |
IGHV3 | -1 (aa 10) | 8 | 9 | -3 (aa 73,81,82) | 2 | |
IGHV4 | -1 (aa 10) | 8 | 8 | -3 (aa 73,81,82) | 2 | |
IGHV5 | -1 (aa 10) | 10 | 11(1) | -1 (aa 73) | 2 | |
IGHV6 | -1 (aa 10) | 8 | 7 | -1 (aa 73) | 2 | |
IGHV7 | -1 (aa 10) | 8 | 9 | -3 (aa 73,82,83) | 2 | |
IGHV8 | -1 (aa 10) | 8 | 8 | -1 (aa 73) | 2 |
IMGT notes:
(1) | Insertion of 1 amino acid between positions 60 and 61 in CDR2-IMGT (60A). |
(2) | Probable length of germline CDR3-IMGT is 2 amino acids but needs to be confirmed with a germline sequence. |
Created: 23/07/2003
Author: Nathalie Bosc