Only FUNCTIONAL and ORF V-GENEs are shown.
IGHV genes | FR1-IMGT 1 to 26 | CDR1-IMGT 27 to 38 | FR2-IMGT 39 to 55 | CDR2-IMGT 56 to 65 | FR3-IMGT 66 to 104 | CDR3-IMGT (germline V-GENE) 105 to 115 |
(24 to 27) | (7,8,10,12) | (17) | (6 to 9) | (36 to 38) | (2) | |
IGHV1S1 IGHV1S2 IGHV1S3 IGHV1S4 IGHV1S5 IGHV1S6 IGHV1S7 | -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) | 7 7 8 8 8 8 8 | 9 8 7 8 9 8 8 | -1 (aa 73) | 2 | |
IGHV2S1 IGHV2S2 IGHV2S3 | +2 (aa 6A,6B) -1 (aa 10) | 8 | 6 | -1 (aa 73) | 2 (1) | |
IGHV3S1 IGHV3S2 IGHV3S3 IGHV3S4 | -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) | 10 | 7 | -1 (aa 73) | 2 (1) | |
IGHV4S1 | -2 (aa 1,10) | 8 | 9 | -1 (aa 73) | 2 (1) | |
IGHV5S1 IGHV5S2 IGHV5S3 IGHV5S4 IGHV5S5 IGHV5S6 IGHV5S7 IGHV5S8 IGHV5S9 | -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) | 8 | 8 8 8 6 8 8 8 8 7 | -1 (aa 73) | 2 (1) | |
IGHV6S1 IGHV6S2 IGHV6S3 IGHV6S4 IGHV6S5 IGHV6S6 IGHV6S7 IGHV6S8 IGHV6S9 | -2 (aa 1,10) -2 (aa 1,10) -2 (aa 1,10) -2 (aa 1,10) -2 (aa 1,10) -2 (aa 1,10) -2 (aa 1,10) -2 (aa 1,10) -2 (aa 1,10) | 7 | 6 6 6 7 6 6 6 6 6 | -1 (aa 73) | 2 (1) | |
IGHV7S1 | -1 (aa 10) | 12 | 7 | -1 (aa 73) | 2 (1) | |
IGHV8S1 IGHV8S2 IGHV8S3 IGHV8S4 IGHV8S5 IGHV8S6 IGHV8S7 IGHV8S8 IGHV8S9 IGHV8S10 IGHV8S11 | -2 (aa 10,11) -1 (aa 10) -1 (aa 10) | 8 | 7 | -3 (aa 73,82,83) | 2 (1) | |
IGHV9S1 IGHV9S2 IGHV9S3 IGHV9S4 IGHV9S5 IGHV9S6 | -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) -1 (aa 10) | 8 | 7 | -1 (aa 73) | 2 (1) | |
IGHV10S1 | -1 (aa 10) | 8 | 6 | -1 (aa 73) | 2 (1) | |
IGHV11S1 | -1 (aa 10) | 8 | 7 | -2 (aa 73,82) | 2 (1) |
IMGT Note:
(1) | Probable CDR3-IMGT length but needs to be confirmed with germline sequences. |
Created: 25/11/1997
Last updated: Friday, 22-Sep-2023 18:17:41 CEST
Author: Manuel Ruiz and Nathalie Bosc