Only FUNCTIONAL and ORF V-GENEs are shown.
The proteolytic cleavage site between the leader peptide and the V-REGION is putative and the assignment of amino acid 1 to one or the other region is uncertain.
TRBV
genes |
FR1-IMGT
1 to 26 |
CDR1-IMGT
27 to 38 |
FR2-IMGT
39 to 55 |
CDR2-IMGT
56 to 65 |
FR3-IMGT
66 to 104 |
CDR3-IMGT
(germline V-GENE) 105 to 115 |
(26) | (6,7,9) | (17) | (3,4,6-8,10) | (36,39) | (2 to 4) (1) | |
TRBV1S1 to TRBV1S5 |
7 | 8 | -2 (aa 73, 82) | 3(1) | ||
TRBV2S1 to
TRBV2S27 |
6 | 4 | -2 (aa 73, 82) | 2,3,4 (1) | ||
TRBV3S1, TRBV3S2 |
6 | 8 | -1 (aa 82), +1 (aa 96A) | 3 (1) | ||
TRBV4S1 | 6 | 8 | -3 (aa 81, 82, 83) | 3 (1) | ||
TRBV5S1 |
|
|
|
|
||
TRBV6S1 | 9 | 3 | -4 (aa 73, 81, 82, 83) +1 (aa 96A) | 2 (1) | ||
TRBV7S1 to TRBV7S4 |
6 | 7 | -1 (aa 82) | 3 (1) | ||
TRBV8S1 to TRBV8S3 |
6 | 6 | -2 (aa 73, 82) | 3 (1) | ||
TRBV9S1 | 6 | 4 | -3 (aa 81, 82, 83) | 3 (1) | ||
TRBV10S1 | 6 | 7 | -3 (aa 73, 82, 96) | 3 (1) |
IMGT note:
(1) | Probable CDR3-IMGT length but needs to be confirmed with germline sequences. |
Created: 21/11/2002
Author: Géraldine Folch