Only FUNCTIONAL and ORF V-GENEs are shown.
IGHV
subgroup |
FR1-IMGT 1 to 26 | CDR1-IMGT 27 to 38 | FR2-IMGT 39 to 55 | CDR2-IMGT 56 to 65 | FR3-IMGT 66 to 104 | CDR3-IMGT
(germline V-GENE) 105 to 115 |
(25) | (7,8) | (17) | (3,7,8) | (38) | (2,3) | |
1 | -1 (aa 10) | 8 | 7 | -1 (aa 73) | 3 | |
2 | -1 (aa 10) | 8 | 8 | -1 (aa 73) | 3 (1) | |
3 | -1 (aa 10) | 7 | 8 | -1 (aa 73) | 2 (1) | |
4 | -1 (aa 10) | 8 | 3 | -1 (aa 73) | 3 (1) |
The proteolytic cleavage site between the leader peptide and the V-REGION is putative and the assignment of amino acid 1 to one or the other region is uncertain.
IMGT note:
(1) | Probable CDR3-IMGT length but needs to be confirmed with germline sequences. |
Created: 15/11/2001
Author: Nathalie Bosc