Recombination signal sequences

Sequences for generating the recombination signal sequence logos are from the Immunoglobulin FactsBook [1].
Sequences for generating the recombination signal sequence logos are from the T Cell Receptor FactsBook [2].
Only the recombination signals of the allele *01 of each functional V-REGION are shown.
Numbers on the right of each heptamer and nonamer indicate the number of genes where the sequence has been found.

IGH

IGK

IGL

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TRA

TRB

TRG

TRD

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Recombination signal sequence logos

Sequences for generating the recombination signal sequence logos are from the Immunoglobulin FactsBook [1].
Sequences for generating the recombination signal sequence logos are from the T Cell Receptor FactsBook [2].
They comprise only allele *01 of functional V-REGION sequences.

Recombination signal sequence logos were generated using Weblogo [3].

V-RS J-RS
_________________________________________ _________________________________________
V-HEPTAMER V-NONAMER J-NONAMER J-HEPTAMER
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TRB_V7 23 TRB_V9 mid TRB_J9 12 TRB_J7 TRBJ
TRG_V7 23 TRG_V9 mid TRG_J9 12 TRG_J7 TRGJ
TRD_V7 23 TRD_V9 mid TRD_J9 12 TRD_J7 TRDJ
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5'D-RS 3'D-RS
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5'-NONAMER 5'-HEPTAMER 3'-HEPTAMER 3'-NONAMER
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Recombination signal sequence logo for the seven loci

Sequences for generating the recombination signal sequence logos are from the Immunoglobulin FactsBook [1].
Sequences for generating the recombination signal sequence logos are from the T Cell Receptor FactsBook [2].
They comprise only allele *01 of functional V-REGION sequences.

Recombination signal sequence logo was generated using Weblogo [3].

V-RS J-RS
__________________________________________ __________________________________________
V-HEPTAMER V-NONAMER J-NONAMER J-HEPTAMER

Number of sequences for generating the recombination signal sequence logo for the seven loci

Sequences for generating the recombination signal sequence logo are from the Immunoglobulin FactsBook [1] and from the T Cell Receptor FactsBook [2].
They comprise only allele *01 of functional V-REGION sequences.

V-HEPTAMER V-NONAMER J-NONAMER J-HEPTAMER
IGH 35 31 12 12
IGK 36 35 7 7
IGL 32 32 7 7
TRA 45 45 52 51
TRB 48 48 13 14
TRG 6 6 6 6
TRD 3 3 4 4
Total 205 200 101 101

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IMGT references:
[1] Lefranc, M.-P. and Lefranc, G., The Immunoglobulin FactsBook, Academic Press, 458 pages (2001) ISBN:012441351X
[2] Lefranc, M.-P. and Lefranc, G., The T cell receptor FactsBook, Academic Press, 398 pages (2001) ISBN:0124413528
[3] Crooks G. E. et al. Genome Research, 14, 1188-1190 (2004). PMID: 15173120