Recombination signal sequences

Sequences for generating the recombination signal sequence logos are from IMGT/GENE-DB [1].
Only the recombination signals of the allele *01 of each functional V-REGION are shown.
Numbers on the right of each heptamer and nonamer indicate the number of genes where the sequence has been found.


IGH

IGK

IGL

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TRA

TRB

TRG

TRD

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Recombination signal sequence logos

Sequences for generating the recombination signal sequence logos are from IMGT/GENE-DB [1].
They comprise only allele *01 of functional V-REGION sequences.

Recombination signal sequence logos were generated using Weblogo [2].

V-RS J-RS
__________________________________________ __________________________________________
V-HEPTAMER V-NONAMER J-NONAMER J-HEPTAMER
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TRB_V7 23 TRB_V9 mid TRB_J9 12 TRB_J7 TRBJ
TRG_V7 23 TRG_V9 mid TRG_J9 12 TRG_J7 TRGJ
TRD_V7 23 TRD_V9 mid TRD_J9 12 TRD_J7 TRDJ
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5'D-RS 3'D-RS
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5'-NONAMER 5'-HEPTAMER 3'-HEPTAMER 3'-NONAMER
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Recombination signal sequence logo for the seven loci

Sequences for generating the recombination signal sequence logos are from IMGT/GENE-DB [1].
They comprise only allele *01 of functional V-REGION sequences.

Recombination signal sequence logo was generated using Weblogo [2].

V-RS J-RS
__________________________________________ __________________________________________
V-HEPTAMER V-NONAMER J-NONAMER J-HEPTAMER
           V7 23 V9 mid J9 12 J7

Number of sequences for generating the recombination signal sequence logo for the seven loci

Sequences used for generating the recombination signal sequence logos for the seven loci are from IMGT/GENE-DB [1].
They comprise only allele *01 of functional V-REGION sequences.

V-HEPTAMER V-NONAMER J-NONAMER J-HEPTAMER
IGH 34 26 4 4
IGK 93 90 4 4
IGL 3 3 3 3
TRA 80 77 37 37
TRB 22 21 11 11
TRG 7 7 4 4
TRD 5 5 2 2
Total 244 229 65 65

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IMGT references:
[1] Giudicelli, V. et al. Nucleic Acids Res., Jan 2005; 33: D256 - D261. PMID: 15608191 LIGM:292 pdficon
[2] Crooks G. E. et al. Genome Research, 14, 1188-1190 (2004). PMID: 15173120