Gene table: Mouse (Mus musculus) IGKV

Print of this table: Martinez, C. and Lefranc, M.-P., Exp. Clin. Immunogenet., 15, 184-193 (1998) pdf

Click here for correspondence between Mouse (Mus musculus) IMGT IGKV subgroups and previous designations.

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T), and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between:
- parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
- brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

Mus musculus IGKV genes, which have not yet been mapped, are designated by a number for the subgroup, followed by the letter S and a number. Orphon genes are designated by a number for the subgroup followed by a slash, OR (for ORPHON), a dash and a specific gene number.
The IGKV1/OR-1 and IGKV1/OR-2 orphon genes have been proposed to be localised on chromosomes 16 and 19, respectively [Schupp, I. et al, Immunogenetics 45,180-187 (1997)][27].

Click on an accession number to get the sequence and additional information (IMGT annotations, IMGT flat file, Coding regions...).

IGKV
subgroup		IGKV
gene name		FctRTPrReference sequencesAccession numbersSequences from the literature
1 1S1 F + + + K5.1 D00080/M15566 [6] V-1A[M28131][22]
1S2 F + + + K1A5 D00081 [6] [M15567][6], V-1C[M28133][22]
1S3 F + + + K18.1 D00082 [6] [M15568][6]
1S4 F + + + V-IB M28132 [22]  
1S5 F + +   V-1Cf M28134 [22]  
1S6 F + +   70/3 Z72384 [27]  
1S7 F + +   70/1 Z72382 [27]  
1/OR-1 P(1)       70/2 Z72383 [27]  
1/OR-2 P(2)       68 Z72381 [27]  
2 2S1 F + +   167 J00562 [29] 24[K02415][15]
2S2 F + +   24A K02417 [15]  
2S3 F + +   24B K02418 [15]  
2S4 F       CaV24 M80407 [13]  
2S5 P(3)       CaV24A M80408 [13]  
2S6 F       CaV24B-1 M80409 [13]  
2S7 F       CaV24B-2 M80410 [13]  
2S8 P(4)       CaV24D-1 M80411 [13]  
2S9 P(5)       CaV24D-2 M80412 [13]  
2S10 P(6)       CaV24D-3 M80413 [13]  
3 3S1 F + +   21E K02159 [11]  
3S2 F + +   21B K02160 [11]  
3S3 F + +   1,6kb K02158 [11]  
3S4 F + +   21C K02161 [11]  
3S5 F + +   18kb K02162 [11]  
3S6 F + +   21A X16954 [1]  
3S7 F + +   21G X16955 [1]  
3S8 F + +   21-4 Y15968 [18]  
3S9 P(7)       21-6 Y15969 [18]  
3S10 P(8)       21-8 Y15971 [18]  
3S11 F       21-9 Y15972 [18]  
3S12 P(9)       21-11 Y15973 [18]  
4 4S1 F       L8 J00575/V01565 [14]  
4S2 F(10) + +   S107b K00884 [19] R1[8]
4S3 F(11) + +   X24 X05555 [12] H6[8]
4S4 F(12) + +   VOx1 S37664 [8] H3[8]
4S5   + +   R9 [8]  
4S6   + +   H13 [8]  
4S7         H9 [8]  
4S8   + +   H4 [8]  
4S9         H8 [8]  
4S10   + +   R13 [8]  
4S11         R2 [8]  
4S12         H2 [8]  
4S13   + +   H1 [8]  
4S14   + +   R11 [8]  
5 5S1 F + +   L7 V01564 [24]  
6 6S1 F + +   V-Sera M14360 [4]  
6S2 F + +   V-Serb M14361 [4]  
6S3 F + +   SK/CamRK M24937 [25]  
6S4 F + +   PERA/Ei L36249 [25]  
6S5 F + +   19-14 Y15975 [18]  
6S6 F + +   19-15 Y15976 [18]  
6S7 F + +   19-17 Y15978 [18]  
6S8 F + +   19-20 Y15981 [18]  
7 7S1 F         AF044198 [32]  
7S2 P(13)       8-22 Y15983 [18]  
8 8S1 F(14) + + + GLvk50 L17135 [10]  
8S2 F + +   8-16 Y15977 [18]  
8S3 ORF(15)       8-18 Y15979 [18]  
8S4 F + +   8-19 Y15980 [18]  
8S5 F + +   8-21 Y15982 [18]  
9 9S1 F +     vk41 V00804/J00566 [28] [AF003293][30](17)
9S2 ORF(16)       M173b K00880 [21]  
9S3 F(17)       VK9a AF003294 [30]  
9S4 F(17)       VK9b AF003295 [30]  
10 10S1 F + + + 91A3 M15520 [26] Id(CR)[X05795][33](18), AJ1[M54905][17]
10S2 F       AKR1 M54903 [17]  
10S3 F +     AKR2 M54904 [17]  
10S4 F + + + AJ2 M54906 [17]  
10S5 F +     PERU1 M54907 [17]  
10S6 F       PERU2 M54908 [17]  
10S7 F       VK10c AF029261 [9]  
11 11S1 (ORF)(19)       V11 M10116 [16]#c  
12 12S1 F + +   k2 J00545/V00778 [23]  
12S2 F(20)       k3 J00546 [28]  
13 13S1 [F](21)       Vk34B M35154 [31]°  
13S2 [F](21)       Vk34A M35155 [31]°  
13S3 [F](21)       Vk34C M35156 [31]°  
14 14S1 F + +   L6 V01563 [24]  
14S2 F(22)         M24179 [3]  
14S3 P(23)       9B.8 X58992 [20]  
14S4 P(24)       294A9 Z72385 [27]  
15 15S1 (P)(25)       Vk32 M33992 [7]#c  
15S2 (F)       Vk32Liv U27011 [2]#c  
16 16S1 (F) + + + 87.92.6 M13833 [5]#c  
17 17S1 P(26)       294A9 Z72386 [27]  
#c Rearranged cDNA.
° genomic DNA, but not known as being germline or rearranged.

IMGT notes:
(1) DELETION of 16 bp at position 59/60 including the L-PART1 INIT-CODON, DELETION of 2 bp at position 518/519 in the FR1-IMGT, and DELETION of 1 bp at position 743/744 in the FR3-IMGT, leading to frameshifts in the V-REGION.
(2) INSERTION of 1 bp (position 645) in CDR1-IMGT, and DELETION of 1 bp at position 796/797 in FR3-IMGT, leading to frameshifts.
(3) DELETION of 5 bp at position 21/22 in the FR1-IMGT leading to a frameshift and mutations in the V-REGION.
(4) INSERTION of 1 bp (position 879) in FR3-IMGT leading to a frameshift.
(5) INSERTION of 1 bp (position 828) in FR3-IMGT leading to a frameshift.
(6) STOP-CODONs in FR2-IMGT and INSERTION of 1 bp (position 780) in FR3-IMGT.
(7) INSERTION of 566 bp (positions 706-1271) in CDR3-IMGT.
(8) STOP-CODON (positions 332-334) in FR1-IMGT.
(9) INSERTION of 566 bp (positions 713-1278) in CDR3-IMGT.
(10) Partial V-GENE in 5' : partial L-PART1.
(11) Partial V-GENE : no L-PART1, partial L-PART2, and no V-NONAMER.
(12) Partial V-GENE : no L-PART1, no L-PART2, and no V-HEPTAMER, no V-NONAMER.
(13) STOP-CODON in FR2-IMGT, INSERTIONs in FR3-IMGT, and DELETION in CDR3-IMGT, leading to frameshifts.
(14) Partial V-GENE : no L-PART1, no L-PART2, and partial CDR3-IMGT.
(15) Non canonical V-HEPTAMER: CACAGAG instead of CACAGTG.
(16) CONSERVED-TRP is replaced by Leu in FR2-IMGT.
(17) Partial V-GENE : no V-HEPTAMER, and no V-NONAMER.
(18) Partial V-GENE in 5' : no L-PART1 and partial L-PART2.
(19) Defective DONOR-SPLICE : GC instead of GT.
(20) Partial V-GENE in 3' : no V-NONAMER.
(21) Partial V-GENE : partial L-PART1,partial V-REGION, partial FR3-IMGT (AA 102 to 104 are absent) and no CDR3-IMGT.
(22) Partial V-REGION: partial FR3-IMGT (AA 84 to 104 are absent) and no CDR3-IMGT.
(23) INSERTION of 2 bp (positions 344-345) leading to a frameshift in FR3-IMGT and defective ACCEPTOR-SPLICE: TA instead of AG.
(24) DELETION of the ACCEPTOR_SPLICE, DELETION of 12 bp in the FR1-IMGT, DELETION of 1 bp and INSERTION of 1 bp in the CDR3-IMGT.
(25) INSERTION of 4 bp (positions 181-184) leading to a frameshift in FR2-IMGT.
(26) DELETION of 1 bp at position 601/602 in the FR1-IMGT, and DELETION of 3 bp at position 604/605 in the CDR1-IMGT, leading to frameshifts.

References:
[1] Alanen, A. et al., Eur. J. Immunol., 19, 1961-1963 (1989).
[2] Bloom, D. D. et al., J. Immunol., 150, 1591-1610 (1993).
[3] Bodary, S. C. et al., EMBO J., 1, 719-724 (1982).
[4] Boyd, R. T. et al., Proc. Natl. Acad. Sci. U.S.A., 83, 9134-9138 (1986).
[5] Bruck, C. et al., Proc. Natl. Acad. Sci. USA, 83, 6578-6582 (1986).
[6] Corbet, S. et al., EMBO J., 4, 3439-3445 (1985).
[7] D'Hootelaere, L. A. et al., J. Immunol., 145, 2706-2712 (1990).
[8] Even, J. et al., EMBO J., 4, 3439-3445 (1985) and
Milstein, C. et al., Eur. J. Immunol., 22, 1627-1634 (1992).
[9] Fitzsimmons, S.P. et al., Unpublished.
[10] Foster, M.H. et al., J. Immunol., 151, 814-824 (1993).
[11] Heinrich, G. et al., J. Exp. Med., 159, 417-435 (1984).
[12] Heller, M. et al., J. Exp. Med., 166, 637-646 (1987).
[13] Henderson, T.J. et al., Immunogenetics, 37, 426-436 (1993).
[14] Hoechtl, J. et al., Proc. Natl. Acad. Sci. U.S.A., 79, 1383-1387 (1982).
[15] Joho, R. et al., EMBO J., 3, 185-191 (1984).
[16] Kelley, D.E. et al., Mol. Cell. Biol., 5, 1660-1675 (1985).
[17] Kim, S.O. et al., Immunogenetics, 34, 231-241 (1991).
[18] Kirschbaum, T. et al., Eur. J. Immunol., 28, 1458-1466 (1998).
[19] Kwan, S.P et al., Cell, 26, 57-66 (1981).
[20] Lawler, A. M. et al., Mol. Immunol., 29, 295-301 (1992).
[21] Max, E.E. et al., Cell, 21, 793-799 (1980).
[22] Ng, K.H. et al., J. Immunol., 143, 638-648 (1989).
[23] Nishioka, Y. et al., J. Biol. Chem., 255, 3691-3694 (1980).
[24] Pech, M. et al., Nature, 291, 668-670 (1981).
[25] Ponath, P.D. et al., Immunogenetics, 29, 249-257 (1989).
[26] Sanz, I. et al., Proc. Natl. Acad. Sci. U.S.A., 84, 1085-1089 (1987).
[27] Schupp, I. W. et al., Immunogenetics, 45, 180-187 (1997).
[28] Seidman, J.G. et al., Proc. Natl. Acad. Sci. U.S.A., 75, 3881-3885 (1978).
[29] Selsing, E. et al., Cell, 25, 47-58 (1981).
[30] Ulrich, H. D. et al., Immunogenetics, 47, 91-95 (1997).
[31] Valiante, N.M. et al., Unpublished.
[32] Whitcomb, E.A. et al., J. Immunol., 160, 4904-4913 (1998).
[33] Wysocki, L.J. et al., J. Exp. Med., 166, 1-11 (1987).

Created: 30/07/1998
Last updated: Friday, 22-Sep-2023 18:19:17 CEST
Author: Christèle Martinez