IMGT Repertoire (IG and TR)

Print of this table: Barbié, V. and Lefranc, M.-P., Exp. Clin. Immunogenet., 15, 171-183 (1998). PMID: 9813414

Distal and proximal V-CLUSTERs (for the haplotypes with both clusters).

76 IGKV genes belonging to 7 subgroups, on 1 800 kilobases:
- 35 FUNCTIONAL
- 6 ORF (Open Reading Frame)
- 30 PSEUDOGENE
- 4 FUNCTIONAL or PSEUDOGENE
- 1 FUNCTIONAL or ORF
Potential repertoire: 35-40 FUNCTIONAL IGKV genes belonging to 6 subgroups

Subgroup	Functional	ORF	Pseudogene	Total
IGKV1	17(+2)*	3	7(+2)*	29
IGKV2	9(+1)*	1	16(+1)*	27
IGKV3	5(+2)*	1(+1)*	6(+1)*	14
IGKV4	1	-	-	1
IGKV5	1	-	-	1
IGKV6	2	1	-	3
IGKV7	-	-	1	1
Total	35(+5)*	6(+1)*	30(+4)*	76

* An asterisk indicates that the following genes have alleles with different functionalities:
FUNCTIONAL or PSEUDOGENE (IGKV1-13, IGKV1-39, IGKV2-29, IGKV3D-15)
FUNCTIONAL or ORF (IGKV3D-20)

Proximal V-CLUSTER (for the haplotypes without the distal V-CLUSTER)

40 IGKV genes belonging to 7 subgroups, on 600 kilobases:
- 19 FUNCTIONAL
- 2 ORF (Open Reading Frame)
- 16 PSEUDOGENE
- 3 FUNCTIONAL or PSEUDOGENE
Potential repertoire: 19-22 FUNCTIONAL IGKV genes belonging to 6 subgroups

Subgroup	Functional	ORF	Pseudogene	Total
IGKV1	9(+2)*	1	3(+2)*	15
IGKV2	4(+1)*	-	9(+1)*	14
IGKV3	3	1	3	7
IGKV4	1	-	-	1
IGKV5	1	-	-	1
IGKV6	1	-	-	1
IGKV7	-	-	1	1
Total	19(+3)*	2	16(+3)*	40

* An asterisk indicates that the following genes have alleles with different functionalities:
FUNCTIONAL or PSEUDOGENE (IGKV1-13, IGKV1-39, IGKV2-29).

IMGT Repertoire (IG and TR)

Number of germline genes and potential repertoire: Human (Homo sapiens) IGKV at 2p11.2

Distal and proximal V-CLUSTERs (for the haplotypes with both clusters).

Proximal V-CLUSTER (for the haplotypes without the distal V-CLUSTER)