Human IGHV1-69 gene

Based on the IMGT Alignment of alleles: Human IGHV1-69 [2] we can deduce from Figure 4 in [1], that there are two well known IMGT IGHV1-69 alleles per individual.

Patient ID IGHV1-69 genotype
198IGHV1-69*02/IGHV1-69*01
213IGHV1-69*06/IGHV1-69*01
12IGHV1-69*01/IGHV1-69*04
34IGHV1-69*04/IGHV1-69*01
37IGHV1-69*06/IGHV1-69*01
41IGHV1-69*06/IGHV1-69*01
78IGHV1-69*04/IGHV1-69*04
109IGHV1-69*04/IGHV1-69*02
108IGHV1-69*04/IGHV1-69*04

Unfortunately, the authors did not check if the additional sequences in individuals 198 and 34 were due to PCR artefacts or if they represented additional copies (and new alleles) of an eventual duplicated IGHV1-69 gene. This would have been useful information regarding a potential duplication (Marie-Paule Lefranc, 16/08/2006 in answer to a question of Felix Breden on the number of copies of the human IGHV1-69 gene).

IMGT references
[1] Vencovsky, J. et al., Rheumatology 41, 401-410 (2002) PMID: 11961170
[2] Lefranc, M.-P. and Lefranc, G., The immunoglobulin FactsBook, Academic Press, London, 458 pages (2001) ISBN:012441351X