Reference for this table: Lefranc, M.-P., Pallarès, N. and Frippiat, J.-P., Hum. Genet., 104, 361-369 (1999)

Probes:pJlambda2 clone [3]
pClambda3 clone [3]

IGLC gene name RFLP alleles Enzymes Fragments (kb) Polymorphism type (1) Frequencies
American (2) [5] American with SLE (2) (3) [5] Black African [3] Caucasoid Caucasoid with Graves' disease [4] English [2] English with RA (3) [2] French [3] Japanese [6] Lebanese [3] Tunisian [3] Venezuelan [7]
[1] [4]
IGLC2 and/or IGLC3 *A1 EcoRI 8   0.79 0.79 0.63 0.75 0.78 0.86 0.83 0.92 0.80 0.21 0.72 0.65 0.65
*A2 13 I 0.00 0.01 0.11 0.05 0.00 0.00 0.02 0.02 0.04 0.22 0.07 0.11 0.04
*A3 18 I 0.18 0.18 0.21 0.20 0.22 0.14 0.13 0.06 0.15 0.50 0.20 0.23 0.30
*A4 23 I 0.03 0.02 0.02 0.01 0.00 0.00 0.01 0.00 0.02 0.05 0.02 0.02 0.10
*A5 28 I 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.02 0.00 0.00 0.00

IMGT notes:

(1) RS, polymorphic Restriction Sites; D, Deletion; I, Insertion.
(2) Racially mixed.
(3) RA, Rheumatoïd arthritis; SLE, Systemic lupus erythematosus.

References :

[1] Taub, R.A. et al., Nature, 304, 172-174 (1983).
[2] Sidebottom, D. et al., Ann.Rheum Dis., 46, 587-589 (1987).
[3] Ghanem, N. et al., Exp. Clin. Immunogenet., 5, 186-195 (1988).
[4] Williams, R.C. et al., J. Clin. Invest., 82, 1306-1312 (1988).
[5] Paul, E. et al., J. Immunol., 147, 2771-2776 (1991).
[6] Kay, P.H. et al., Immunogenetics, 35, 341-343 (1992).
[7] Blasini, A.M. et al., Lupus, 5, 300-302 (1996).

Created: 04/08/1999
Authors: Violaine Moreau and Marie-Paule Lefranc