Reference for this table: Lefranc, M.-P., Pallarès, N. and Frippiat, J.-P., Hum. Genet., 104, 361-369 (1999)

Probes used are IGLV subgroup specific and described in the corresponding publications.

IGLV gene name RFLP alleles Enzymes Fragments (kb) Polymorphism type (1) Frequencies
American (2) American with SLE (2) (3) Caucasoid Caucasoid with RA (3) French Japanese Japanese with DCM (3) Japanese with silicosis Mandenka (4) Tunisian
1-41 *A1 KpnI (5) 10.5 I/RS     0.47 [5]              
*A2 4.6 RS     0.31 [5]              
*A3 17.0 RS     0.19 [5]              
*A4 24.0 RS     0.03 [5]              
2-8 *A1 HindIII 16.0 [1]/20.0 [3]   0.39 [3] 0.48 [3] 0.50 [1]              
*A2 9.0 [1]/10.0 [3]   0.61 [3] 0.52 [3] 0.50 [1]              
3-19 *A1 HindIII 7.8       0.69 [2]              
*A2 3.2       0.31 [2]              
5-39 *A1 HindIII 3.9                      
*A2 - D                 0.35 [8]  
6-57 *A1 HindIII 5.2                   0.98 [8]  
*A2 7.4                   0.01 [8]  
*A3 7.6                   0.01 [8]  
7-43 *A1 BamHI (5) 4.7 [5]/5.3 [4][6] RS     0.52 [5]     0.55 [4] 0.39 [4] 0.38 [6]    
*A2 3.0 [5]/3.3 [4][6] RS     0.48 [5]     0.45 [6] 0.61 [4] 0.62 [6]    
*B1 KpnI (5) 16.0 I/RS     0.47 [5]              
*B2 13.0 RS     0.31 [5]              
*B3 17.0 RS     0.19 [5]              
*B4 24.0 RS     0.03 [5]              
*C1 TaqI 12.9       0.46 [7] 0.49 [7]            
*C2 9.2       0.34 [7] 0.36 [7]            
*C3 4.2       0.17 [7] 0.15 [7]            
8-61 *A1 HindIII 7.3           1.00 [8]       1.00 [8] 0.96 [8]
*A2 - D         0.00 [8]       0.00 [8] 0.04 [8]
(I)-42 *A1 BamHI (5) 4.7 RS     0.52 [5]              
*A2 3.0 RS     0.48 [5]              
*B1 KpnI (5) 16 I/RS     0.47 [5]              
*B2 13 RS     0.31 [5]              
*B3 17 RS     0.19 [5]              
*B4 24 RS     0.03 [5]              

IMGT notes:

(1) RS, polymorphic Restriction Sites; D, Deletion; I, Insertion.
(2) Racially mixed.
(3) DCM, Dilated cardiomyopathy; RA, Rheumatoïd arthritis; SLE, Systemic lupus erythematosus.
(4) East Senegal.
(5) Four different haplotypes have been defined by the KpnI polymorphic restriction fragments of the IGLV7-43, (I)-42, and V1-41 genes, with associated polymorphic BamHI fragments of the 7-43 and (I)-42 genes (see table 2 in reference [5]).

References :

[1] Blancher, A. et al., Nucleic Acids Res., 18, 6178 (1990).
[2] Chuchana, P. et al., Nucleic Acid Res., 18, 6179 (1990).
[3] Paul, E. et al., J. Immunol., 147, 2771-2776 (1991).
[4] Nishi, H. et al., Jpn. Circ. J., 56, 1054-1061 (1992).
[5] Chuchana, P. et al., Am. J. Hum. Genet., 53, 518-525 (1993).
[6] Honda, K. et al., Am. J. Respir. Cell. Mol. Biol., 8, 106-111 (1993).
[7] Sidebottom, D. et al., Exp. Clin. Immunogenet., 10, 129-136 (1993).
[8] Lefranc, M.-P. et al., Hum. Genet., 104, 361-369 (1999).

Created: 04/08/1999
Authors: Violaine Moreau and Marie-Paule Lefranc